Respiratory Chain Inhibition Induces Tolerance to Focal Cerebral Ischemia

The authors show that the inhibitor of the succinate dehydrogenase, 3-nitroproprionic acid (3-NPA), which in high doses and with chronic administration is a neurotoxin, can induce profound tolerance to focal cerebral ischemia in the rat when administered in a single dose (20 mg/kg) 3 days before isc...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 1999-11, Vol.19 (11), p.1229-1237
Hauptverfasser:	Wiegand, F., Liao, W., Busch, C., Castell, S., Knapp, F., Lindauer, U., Megow, D., Meisel, A., Redetzky, A., Ruscher, K., Trendelenburg, G., Victorov, I., Riepe, M., Diener, H. C., Dirnagl, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Ischemia - metabolism Brain Ischemia - prevention & control Convulsants - administration & dosage Free Radicals Ischemic Preconditioning Male Medical sciences Neurology Nitro Compounds Propionates - administration & dosage Rats Rats, Wistar Succinate Dehydrogenase - antagonists & inhibitors Vascular diseases and vascular malformations of the nervous system
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