Acoustically Active Lipospheres Containing Paclitaxel: A New Therapeutic Ultrasound Contrast Agent

RATIONALE AND OBJECTIVES.Paclitaxel-carrying lipospheres (MRX-552) were developed and evaluated as a new ultrasound contrast agent for chemotherapeutic drug delivery. METHODS.Paclitaxel was suspended in soybean oil and added to an aqueous suspension of phospholipids in vials. The headspace of the vi...

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Veröffentlicht in:	Investigative radiology 1998-12, Vol.33 (12), p.886-892
Hauptverfasser:	UNGER, EVAN C, McCREERY, THOMAS P, SWEITZER, ROBERT H, CALDWELL, VERONICA E, WU, YUNQIU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Contrast Media - chemistry Contrast Media - pharmacology Contrast Media - toxicity Drug Carriers Drug Evaluation, Preclinical HeLa Cells Humans Liposomes Male Mice Mice, Inbred BALB C Microspheres Paclitaxel - chemistry Paclitaxel - pharmacology Paclitaxel - toxicity Particle Size Phantoms, Imaging Sonication Time Factors Ultrasonography - methods
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