Experimental Gallstone Dissolution with Methyl-Tert-Butyl Ether (MTBE) and Transcutaneous Ultrasound Energy
The simultaneous application of ultrasound energy greatly accelerated the rate of cholesterol gallstone dissolution by methyl-tert-butyl ether (MTBE). In vitro experiments using this treatment showed that a 498-mg stone burden could be dissolved in 19.5 minutes, approximately 100% faster than what c...
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| Veröffentlicht in: | Investigative radiology 1990-02, Vol.25 (2), p.146-152 |
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| container_title | Investigative radiology |
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| creator | GRIFFITH, STEVEN L BURNEY, BRYAN T FRY, FRANCIS J FRANKLIN, THOMAS D |
| description | The simultaneous application of ultrasound energy greatly accelerated the rate of cholesterol gallstone dissolution by methyl-tert-butyl ether (MTBE). In vitro experiments using this treatment showed that a 498-mg stone burden could be dissolved in 19.5 minutes, approximately 100% faster than what could be achieved with MTBE alone. Pigs (n = 13) with surgically implanted gallstones were treated with MTBE and transcutaneously applied ultrasound from a prototype system built for clinical studies. The average stone reduction of all pigs was 470.46 mg ± 60.44 mg; 91.39% of an average implanted burden of 515.08 ± 18.03 mg. Control group pigs (n = 9), receiving only an MTBE infusion, showed an average stone reduction of 51.77%. Enzymes indicative of hepatocellular injury showed no significant abnormalities after 6 weeks. Gallbladder ablation with a fibrous remnant (ie, no mucosa, no lumen, patent cystic duct) occurred in 10 (70%) of the pigs. |
| doi_str_mv | 10.1097/00004424-199002000-00010 |
| format | Article |
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In vitro experiments using this treatment showed that a 498-mg stone burden could be dissolved in 19.5 minutes, approximately 100% faster than what could be achieved with MTBE alone. Pigs (n = 13) with surgically implanted gallstones were treated with MTBE and transcutaneously applied ultrasound from a prototype system built for clinical studies. The average stone reduction of all pigs was 470.46 mg ± 60.44 mg; 91.39% of an average implanted burden of 515.08 ± 18.03 mg. Control group pigs (n = 9), receiving only an MTBE infusion, showed an average stone reduction of 51.77%. Enzymes indicative of hepatocellular injury showed no significant abnormalities after 6 weeks. Gallbladder ablation with a fibrous remnant (ie, no mucosa, no lumen, patent cystic duct) occurred in 10 (70%) of the pigs.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-199002000-00010</identifier><identifier>PMID: 2312251</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Animals ; Cholelithiasis - therapy ; Energy Transfer ; Ethers - therapeutic use ; Humans ; Lithotripsy ; Methyl Ethers ; Solvents - therapeutic use ; Swine</subject><ispartof>Investigative radiology, 1990-02, Vol.25 (2), p.146-152</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3550-44726835df32da950ee53a4aca6a52f0ad0fc92c6b0031f81b4711d2c8fbdca83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2312251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GRIFFITH, STEVEN L</creatorcontrib><creatorcontrib>BURNEY, BRYAN T</creatorcontrib><creatorcontrib>FRY, FRANCIS J</creatorcontrib><creatorcontrib>FRANKLIN, THOMAS D</creatorcontrib><title>Experimental Gallstone Dissolution with Methyl-Tert-Butyl Ether (MTBE) and Transcutaneous Ultrasound Energy</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>The simultaneous application of ultrasound energy greatly accelerated the rate of cholesterol gallstone dissolution by methyl-tert-butyl ether (MTBE). In vitro experiments using this treatment showed that a 498-mg stone burden could be dissolved in 19.5 minutes, approximately 100% faster than what could be achieved with MTBE alone. Pigs (n = 13) with surgically implanted gallstones were treated with MTBE and transcutaneously applied ultrasound from a prototype system built for clinical studies. The average stone reduction of all pigs was 470.46 mg ± 60.44 mg; 91.39% of an average implanted burden of 515.08 ± 18.03 mg. Control group pigs (n = 9), receiving only an MTBE infusion, showed an average stone reduction of 51.77%. Enzymes indicative of hepatocellular injury showed no significant abnormalities after 6 weeks. Gallbladder ablation with a fibrous remnant (ie, no mucosa, no lumen, patent cystic duct) occurred in 10 (70%) of the pigs.</description><subject>Animals</subject><subject>Cholelithiasis - therapy</subject><subject>Energy Transfer</subject><subject>Ethers - therapeutic use</subject><subject>Humans</subject><subject>Lithotripsy</subject><subject>Methyl Ethers</subject><subject>Solvents - therapeutic use</subject><subject>Swine</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PwzAMhiMEGmPwE5ByhEMgH03XHBmUgbSJS3eO0jSlZVk7JalG_z0dG7thybKs168lPwYAEvxAsJg-4iGiiEaICIExHTo0JMFnYEw4ixGmBJ-D8V5CQoj4Elx5_zWM0ClmIzCijFDKyRis0--tcfXGNEFZOFfW-tA2Br7U3re2C3XbwF0dKrg0oeotyowLaNaF3sI0VMbBu2U2S--hagqYOdV43QXVmLbzcGWDU77tBiVtjPvsr8FFqaw3N8c6AavXNHt-Q4uP-fvz0wJpxjlGUTSlccJ4UTJaKMGxMZypSGkVK05LrApcakF1nGPMSJmQPJoSUlCdlHmhVcImIDns1a713plSbocLleslwXKPT_7hkyd88hffYL09WLddvjHFyXjkNejRQd-1Nhjn17bbGScro2yo5H9fYT-MNnt9</recordid><startdate>199002</startdate><enddate>199002</enddate><creator>GRIFFITH, STEVEN L</creator><creator>BURNEY, BRYAN T</creator><creator>FRY, FRANCIS J</creator><creator>FRANKLIN, THOMAS D</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199002</creationdate><title>Experimental Gallstone Dissolution with Methyl-Tert-Butyl Ether (MTBE) and Transcutaneous Ultrasound Energy</title><author>GRIFFITH, STEVEN L ; BURNEY, BRYAN T ; FRY, FRANCIS J ; FRANKLIN, THOMAS D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3550-44726835df32da950ee53a4aca6a52f0ad0fc92c6b0031f81b4711d2c8fbdca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Cholelithiasis - therapy</topic><topic>Energy Transfer</topic><topic>Ethers - therapeutic use</topic><topic>Humans</topic><topic>Lithotripsy</topic><topic>Methyl Ethers</topic><topic>Solvents - therapeutic use</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GRIFFITH, STEVEN L</creatorcontrib><creatorcontrib>BURNEY, BRYAN T</creatorcontrib><creatorcontrib>FRY, FRANCIS J</creatorcontrib><creatorcontrib>FRANKLIN, THOMAS D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GRIFFITH, STEVEN L</au><au>BURNEY, BRYAN T</au><au>FRY, FRANCIS J</au><au>FRANKLIN, THOMAS D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Gallstone Dissolution with Methyl-Tert-Butyl Ether (MTBE) and Transcutaneous Ultrasound Energy</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>1990-02</date><risdate>1990</risdate><volume>25</volume><issue>2</issue><spage>146</spage><epage>152</epage><pages>146-152</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>The simultaneous application of ultrasound energy greatly accelerated the rate of cholesterol gallstone dissolution by methyl-tert-butyl ether (MTBE). In vitro experiments using this treatment showed that a 498-mg stone burden could be dissolved in 19.5 minutes, approximately 100% faster than what could be achieved with MTBE alone. Pigs (n = 13) with surgically implanted gallstones were treated with MTBE and transcutaneously applied ultrasound from a prototype system built for clinical studies. The average stone reduction of all pigs was 470.46 mg ± 60.44 mg; 91.39% of an average implanted burden of 515.08 ± 18.03 mg. Control group pigs (n = 9), receiving only an MTBE infusion, showed an average stone reduction of 51.77%. Enzymes indicative of hepatocellular injury showed no significant abnormalities after 6 weeks. Gallbladder ablation with a fibrous remnant (ie, no mucosa, no lumen, patent cystic duct) occurred in 10 (70%) of the pigs.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>2312251</pmid><doi>10.1097/00004424-199002000-00010</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Investigative radiology, 1990-02, Vol.25 (2), p.146-152 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Cholelithiasis - therapy Energy Transfer Ethers - therapeutic use Humans Lithotripsy Methyl Ethers Solvents - therapeutic use Swine |
| title | Experimental Gallstone Dissolution with Methyl-Tert-Butyl Ether (MTBE) and Transcutaneous Ultrasound Energy |
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