Acute and Chronic Renal Effects of Radiocontrast in Diabetic: Rats Role of Anesthesia and Risk Factors
The acute and chronic renal effects of the intravenous injection of meglumine diatrizoate sodium 76% (CM), 5 mL/kg body weight were studied in diabetic (DM) and age-matched normal (C) female Sprague-Dawley rats. In acute studies, the effect of anesthesia was assessed for 2 hours. Although anesthesia...
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| Veröffentlicht in: | Investigative radiology 1989-03, Vol.24 (3), p.206-218 |
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| container_title | Investigative radiology |
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| creator | VAAMONDE, CARLOS A BIER, RUTH T PAPENDICK, REBECCA ALPERT, HELEN GOUVEA, WALTER OWENS, BARBARA PARDO, VICTORIANO |
| description | The acute and chronic renal effects of the intravenous injection of meglumine diatrizoate sodium 76% (CM), 5 mL/kg body weight were studied in diabetic (DM) and age-matched normal (C) female Sprague-Dawley rats. In acute studies, the effect of anesthesia was assessed for 2 hours. Although anesthesia decreased C-inulin clearance (Cin) in both DM and C rats (P |
| doi_str_mv | 10.1097/00004424-198903000-00006 |
| format | Article |
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In acute studies, the effect of anesthesia was assessed for 2 hours. Although anesthesia decreased C-inulin clearance (Cin) in both DM and C rats (P<.001 vs. conscious values), there was no impairment of Cin in either group after administration of CM. In chronic studies, creatinine clearance (Ccr) was followed for 3-4 days after CM administration. Four protocols to assess risk factors in DM and C were usedadult rats with normal hydration (2 A); old dehydrated rats with DM of longduration (2B); rats with prior decreased Ccr (remnant kidney, 2C); and DM rats treated with insulin (2D). No clear-cut nephrotoxicity was apparent in these studies, except that proteinuria increased with CM in Study 2C. A greater severity of renal dysfunction, renal disease, or the association of multiple risk factors may be necessary to induce CM-related nephrotoxicity in the experimental animal. The rat, diabetic or not, may have an inherent resistance to CM-induced renal injury.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-198903000-00006</identifier><identifier>PMID: 2753635</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Aging - physiology ; Anesthesia ; Animals ; Dehydration - complications ; Dehydration - physiopathology ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - diagnostic imaging ; Diabetes Mellitus, Experimental - physiopathology ; Diatrizoate Meglumine - toxicity ; Female ; Glomerular Filtration Rate - drug effects ; Inulin ; Kidney - drug effects ; Kidney - physiopathology ; Kidney Function Tests ; Rats ; Rats, Inbred Strains ; Risk Factors ; Urography</subject><ispartof>Investigative radiology, 1989-03, Vol.24 (3), p.206-218</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4216-63459477462acf981a616b6be3cef503f33fbff416a78fef7d9f318414ee7e163</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2753635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAAMONDE, CARLOS A</creatorcontrib><creatorcontrib>BIER, RUTH T</creatorcontrib><creatorcontrib>PAPENDICK, REBECCA</creatorcontrib><creatorcontrib>ALPERT, HELEN</creatorcontrib><creatorcontrib>GOUVEA, WALTER</creatorcontrib><creatorcontrib>OWENS, BARBARA</creatorcontrib><creatorcontrib>PARDO, VICTORIANO</creatorcontrib><title>Acute and Chronic Renal Effects of Radiocontrast in Diabetic: Rats Role of Anesthesia and Risk Factors</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>The acute and chronic renal effects of the intravenous injection of meglumine diatrizoate sodium 76% (CM), 5 mL/kg body weight were studied in diabetic (DM) and age-matched normal (C) female Sprague-Dawley rats. In acute studies, the effect of anesthesia was assessed for 2 hours. Although anesthesia decreased C-inulin clearance (Cin) in both DM and C rats (P<.001 vs. conscious values), there was no impairment of Cin in either group after administration of CM. In chronic studies, creatinine clearance (Ccr) was followed for 3-4 days after CM administration. Four protocols to assess risk factors in DM and C were usedadult rats with normal hydration (2 A); old dehydrated rats with DM of longduration (2B); rats with prior decreased Ccr (remnant kidney, 2C); and DM rats treated with insulin (2D). No clear-cut nephrotoxicity was apparent in these studies, except that proteinuria increased with CM in Study 2C. A greater severity of renal dysfunction, renal disease, or the association of multiple risk factors may be necessary to induce CM-related nephrotoxicity in the experimental animal. The rat, diabetic or not, may have an inherent resistance to CM-induced renal injury.</description><subject>Aging - physiology</subject><subject>Anesthesia</subject><subject>Animals</subject><subject>Dehydration - complications</subject><subject>Dehydration - physiopathology</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - diagnostic imaging</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diatrizoate Meglumine - toxicity</subject><subject>Female</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Inulin</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiopathology</subject><subject>Kidney Function Tests</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Risk Factors</subject><subject>Urography</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1Ud1KwzAUDqLMOX0EIS9QTZo0bbwbc1NhIBS9Lml6QuO6ZiQZw7e33aZ3npvD-f4uvoMQpuSBEpk_kmE4T3lCZSEJG65khMQFmtKMiYSklFyiKSEpSaSU4hrdhPA1KNKcsAmapPmgYtkUmbneR8Cqb_Ci9a63GpfQqw4vjQEdA3YGl6qxTrs-ehUitj1-tqqGaPXTQA2S0nUw6uY9hNhCsOqYV9qwwSulo_PhFl0Z1QW4O-8Z-lwtPxavyfr95W0xXyeap1QkgvFM8jznIlXayIIqQUUtamAaTEaYYczUxnAqVF4YMHkjDaMFpxwgByrYDBWnXO1dCB5MtfN2q_x3RUk1Nlf9Nlf9NXeERuv9ybrb11to_oznqgaen_iD6yL4sOn2B_BVC6qLbfXfQ9gP1K14Gg</recordid><startdate>198903</startdate><enddate>198903</enddate><creator>VAAMONDE, CARLOS A</creator><creator>BIER, RUTH T</creator><creator>PAPENDICK, REBECCA</creator><creator>ALPERT, HELEN</creator><creator>GOUVEA, WALTER</creator><creator>OWENS, BARBARA</creator><creator>PARDO, VICTORIANO</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198903</creationdate><title>Acute and Chronic Renal Effects of Radiocontrast in Diabetic: Rats Role of Anesthesia and Risk Factors</title><author>VAAMONDE, CARLOS A ; BIER, RUTH T ; PAPENDICK, REBECCA ; ALPERT, HELEN ; GOUVEA, WALTER ; OWENS, BARBARA ; PARDO, VICTORIANO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4216-63459477462acf981a616b6be3cef503f33fbff416a78fef7d9f318414ee7e163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aging - physiology</topic><topic>Anesthesia</topic><topic>Animals</topic><topic>Dehydration - complications</topic><topic>Dehydration - physiopathology</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - diagnostic imaging</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diatrizoate Meglumine - toxicity</topic><topic>Female</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Inulin</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiopathology</topic><topic>Kidney Function Tests</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Risk Factors</topic><topic>Urography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAAMONDE, CARLOS A</creatorcontrib><creatorcontrib>BIER, RUTH T</creatorcontrib><creatorcontrib>PAPENDICK, REBECCA</creatorcontrib><creatorcontrib>ALPERT, HELEN</creatorcontrib><creatorcontrib>GOUVEA, WALTER</creatorcontrib><creatorcontrib>OWENS, BARBARA</creatorcontrib><creatorcontrib>PARDO, VICTORIANO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAAMONDE, CARLOS A</au><au>BIER, RUTH T</au><au>PAPENDICK, REBECCA</au><au>ALPERT, HELEN</au><au>GOUVEA, WALTER</au><au>OWENS, BARBARA</au><au>PARDO, VICTORIANO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute and Chronic Renal Effects of Radiocontrast in Diabetic: Rats Role of Anesthesia and Risk Factors</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>1989-03</date><risdate>1989</risdate><volume>24</volume><issue>3</issue><spage>206</spage><epage>218</epage><pages>206-218</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>The acute and chronic renal effects of the intravenous injection of meglumine diatrizoate sodium 76% (CM), 5 mL/kg body weight were studied in diabetic (DM) and age-matched normal (C) female Sprague-Dawley rats. In acute studies, the effect of anesthesia was assessed for 2 hours. Although anesthesia decreased C-inulin clearance (Cin) in both DM and C rats (P<.001 vs. conscious values), there was no impairment of Cin in either group after administration of CM. In chronic studies, creatinine clearance (Ccr) was followed for 3-4 days after CM administration. Four protocols to assess risk factors in DM and C were usedadult rats with normal hydration (2 A); old dehydrated rats with DM of longduration (2B); rats with prior decreased Ccr (remnant kidney, 2C); and DM rats treated with insulin (2D). No clear-cut nephrotoxicity was apparent in these studies, except that proteinuria increased with CM in Study 2C. A greater severity of renal dysfunction, renal disease, or the association of multiple risk factors may be necessary to induce CM-related nephrotoxicity in the experimental animal. The rat, diabetic or not, may have an inherent resistance to CM-induced renal injury.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>2753635</pmid><doi>10.1097/00004424-198903000-00006</doi><tpages>13</tpages></addata></record> |
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| ispartof | Investigative radiology, 1989-03, Vol.24 (3), p.206-218 |
| issn | 0020-9996 1536-0210 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aging - physiology Anesthesia Animals Dehydration - complications Dehydration - physiopathology Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - diagnostic imaging Diabetes Mellitus, Experimental - physiopathology Diatrizoate Meglumine - toxicity Female Glomerular Filtration Rate - drug effects Inulin Kidney - drug effects Kidney - physiopathology Kidney Function Tests Rats Rats, Inbred Strains Risk Factors Urography |
| title | Acute and Chronic Renal Effects of Radiocontrast in Diabetic: Rats Role of Anesthesia and Risk Factors |
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