Acute and Chronic Renal Effects of Radiocontrast in Diabetic: Rats Role of Anesthesia and Risk Factors

The acute and chronic renal effects of the intravenous injection of meglumine diatrizoate sodium 76% (CM), 5 mL/kg body weight were studied in diabetic (DM) and age-matched normal (C) female Sprague-Dawley rats. In acute studies, the effect of anesthesia was assessed for 2 hours. Although anesthesia...

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Veröffentlicht in:	Investigative radiology 1989-03, Vol.24 (3), p.206-218
Hauptverfasser:	VAAMONDE, CARLOS A, BIER, RUTH T, PAPENDICK, REBECCA, ALPERT, HELEN, GOUVEA, WALTER, OWENS, BARBARA, PARDO, VICTORIANO
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Anesthesia Animals Dehydration - complications Dehydration - physiopathology Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - diagnostic imaging Diabetes Mellitus, Experimental - physiopathology Diatrizoate Meglumine - toxicity Female Glomerular Filtration Rate - drug effects Inulin Kidney - drug effects Kidney - physiopathology Kidney Function Tests Rats Rats, Inbred Strains Risk Factors Urography
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Zusammenfassung:	The acute and chronic renal effects of the intravenous injection of meglumine diatrizoate sodium 76% (CM), 5 mL/kg body weight were studied in diabetic (DM) and age-matched normal (C) female Sprague-Dawley rats. In acute studies, the effect of anesthesia was assessed for 2 hours. Although anesthesia decreased C-inulin clearance (Cin) in both DM and C rats (P
ISSN:	0020-9996 1536-0210
DOI:	10.1097/00004424-198903000-00006