Renal Ablation with Absolute Ethanol: Mechanism of Action
The mechanism of renal ablation by intra-arterial ethanol was studied in 16 mongrel dogs. Ethanol injection rates were varied, and light and electron microscopic studies were performed to detect early parenchymal changes in the kidneys. Pure ischemic injury was also studied as a control. Findings sh...
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| Veröffentlicht in: | Investigative radiology 1984-09, Vol.19 (5), p.416-423 |
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| container_title | Investigative radiology |
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| creator | ELLMAN, BRIAN A PARKHILL, BILLY J MARCUS, PETER B CURRY, THOMAS S PETERS, PAUL C |
| description | The mechanism of renal ablation by intra-arterial ethanol was studied in 16 mongrel dogs. Ethanol injection rates were varied, and light and electron microscopic studies were performed to detect early parenchymal changes in the kidneys. Pure ischemic injury was also studied as a control. Findings showed extensive parenchymal injury plays a significant role in renal ablation with permanent thrombosis as a delayed event. Acute arterial occlusion occurred with slow ethanol injection rates due to embolization by damaged blood components. |
| doi_str_mv | 10.1097/00004424-198409000-00014 |
| format | Article |
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Ethanol injection rates were varied, and light and electron microscopic studies were performed to detect early parenchymal changes in the kidneys. Pure ischemic injury was also studied as a control. Findings showed extensive parenchymal injury plays a significant role in renal ablation with permanent thrombosis as a delayed event. Acute arterial occlusion occurred with slow ethanol injection rates due to embolization by damaged blood components.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-198409000-00014</identifier><identifier>PMID: 6511249</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Angiography ; Animals ; Dogs ; Embolization, Therapeutic ; Ethanol - administration & dosage ; Ethanol - pharmacology ; Ethanol - toxicity ; Injections, Intra-Arterial ; Kidney - drug effects ; Kidney - ultrastructure ; Metrizamide - administration & dosage ; Microscopy, Electron ; Necrosis ; Renal Artery</subject><ispartof>Investigative radiology, 1984-09, Vol.19 (5), p.416-423</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6511249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ELLMAN, BRIAN A</creatorcontrib><creatorcontrib>PARKHILL, BILLY J</creatorcontrib><creatorcontrib>MARCUS, PETER B</creatorcontrib><creatorcontrib>CURRY, THOMAS S</creatorcontrib><creatorcontrib>PETERS, PAUL C</creatorcontrib><title>Renal Ablation with Absolute Ethanol: Mechanism of Action</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>The mechanism of renal ablation by intra-arterial ethanol was studied in 16 mongrel dogs. Ethanol injection rates were varied, and light and electron microscopic studies were performed to detect early parenchymal changes in the kidneys. Pure ischemic injury was also studied as a control. Findings showed extensive parenchymal injury plays a significant role in renal ablation with permanent thrombosis as a delayed event. Acute arterial occlusion occurred with slow ethanol injection rates due to embolization by damaged blood components.</description><subject>Angiography</subject><subject>Animals</subject><subject>Dogs</subject><subject>Embolization, Therapeutic</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - pharmacology</subject><subject>Ethanol - toxicity</subject><subject>Injections, Intra-Arterial</subject><subject>Kidney - drug effects</subject><subject>Kidney - ultrastructure</subject><subject>Metrizamide - administration & dosage</subject><subject>Microscopy, Electron</subject><subject>Necrosis</subject><subject>Renal Artery</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kG1LAzEMx4soc04_gnBfoJr04a713RhzChNB9HXp9Xrcabcb1xvDb2_n5t4ZCElI_iH5EZIh3CHo4h6SCcEERa0E6FTR5CjOyBglzykwhHMyBmBAtdb5JbmK8TONsAL4iIxyiciEHhP95tc2ZNMy2KHt1tmuHZpUxS5sB5_Nh8auu_CQvXiXsjausq7Opm4_ek0uahuivznGCfl4nL_PnujydfE8my6p4-lGyspSopaKqwKV58yiq3jJUEhwQspKcwXOC2V5hbn2UBQ8LxGq_aEVqz2fEHXY6_ouxt7XZtO3K9t_GwSzh2H-YJgTDPMLI0lvD9LNtlz56iQ8fp_64tDfdWHwffwK253vTeNtGBrzH2P-A_RxZw8</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>ELLMAN, BRIAN A</creator><creator>PARKHILL, BILLY J</creator><creator>MARCUS, PETER B</creator><creator>CURRY, THOMAS S</creator><creator>PETERS, PAUL C</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198409</creationdate><title>Renal Ablation with Absolute Ethanol: Mechanism of Action</title><author>ELLMAN, BRIAN A ; PARKHILL, BILLY J ; MARCUS, PETER B ; CURRY, THOMAS S ; PETERS, PAUL C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3004-2bb5195838718e32a1cd3b21450c455d9380ce48a3d169e07736b10d2703d2fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Angiography</topic><topic>Animals</topic><topic>Dogs</topic><topic>Embolization, Therapeutic</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - pharmacology</topic><topic>Ethanol - toxicity</topic><topic>Injections, Intra-Arterial</topic><topic>Kidney - drug effects</topic><topic>Kidney - ultrastructure</topic><topic>Metrizamide - administration & dosage</topic><topic>Microscopy, Electron</topic><topic>Necrosis</topic><topic>Renal Artery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ELLMAN, BRIAN A</creatorcontrib><creatorcontrib>PARKHILL, BILLY J</creatorcontrib><creatorcontrib>MARCUS, PETER B</creatorcontrib><creatorcontrib>CURRY, THOMAS S</creatorcontrib><creatorcontrib>PETERS, PAUL C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ELLMAN, BRIAN A</au><au>PARKHILL, BILLY J</au><au>MARCUS, PETER B</au><au>CURRY, THOMAS S</au><au>PETERS, PAUL C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal Ablation with Absolute Ethanol: Mechanism of Action</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>1984-09</date><risdate>1984</risdate><volume>19</volume><issue>5</issue><spage>416</spage><epage>423</epage><pages>416-423</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>The mechanism of renal ablation by intra-arterial ethanol was studied in 16 mongrel dogs. Ethanol injection rates were varied, and light and electron microscopic studies were performed to detect early parenchymal changes in the kidneys. Pure ischemic injury was also studied as a control. Findings showed extensive parenchymal injury plays a significant role in renal ablation with permanent thrombosis as a delayed event. Acute arterial occlusion occurred with slow ethanol injection rates due to embolization by damaged blood components.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>6511249</pmid><doi>10.1097/00004424-198409000-00014</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-9996 |
| ispartof | Investigative radiology, 1984-09, Vol.19 (5), p.416-423 |
| issn | 0020-9996 1536-0210 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00004424_198409000_00014 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Angiography Animals Dogs Embolization, Therapeutic Ethanol - administration & dosage Ethanol - pharmacology Ethanol - toxicity Injections, Intra-Arterial Kidney - drug effects Kidney - ultrastructure Metrizamide - administration & dosage Microscopy, Electron Necrosis Renal Artery |
| title | Renal Ablation with Absolute Ethanol: Mechanism of Action |
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