The protein kinase C inhibitor, H-7, induces acute lung injury in guinea pigs

OBJECTIVESTo determine if the protein kinase C inhibitor, H-7, alone can cause acute lung injury. In cell studies, H-7 inhibited phorbol myristate acetate-induced neutrophil oxygen radical release. Additionally, one animal study demonstrated that H-7 inhibited phorbol myristate acetate-induced lung...

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Veröffentlicht in:	Critical care medicine 1994-07, Vol.22 (7), p.1167-1173
Hauptverfasser:	Tanigaki, Toshimori, Suzuki, Yukio, Heimer, Dov, Wang, Weizheng, Sussman, Howard H, Ross, William G, Murphy, Gloria A, Ikeda, Hiroshi, Raffin, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Animals Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Cell Membrane Permeability - drug effects Endothelium - drug effects Endothelium - ultrastructure Flow Cytometry Guinea Pigs Humans Isoquinolines - pharmacology Luminescent Measurements Lung - drug effects Lung - physiopathology Lung - ultrastructure Medical sciences Microscopy, Electron Neutrophils - drug effects Neutrophils - metabolism Oxygen - blood Piperazines - pharmacology Pneumology Protein Kinase C - antagonists & inhibitors Random Allocation Respiratory Distress Syndrome, Adult - chemically induced Respiratory Distress Syndrome, Adult - pathology Respiratory Distress Syndrome, Adult - physiopathology Respiratory system : syndromes and miscellaneous diseases Specific Pathogen-Free Organisms
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