Effect of dobutamine on oxygen consumption and fluid and protein losses after endotoxemia

OBJECTIVETo determine the effect of a dobutamine infusion on the relationship between oxygen consumption ( o2) and oxygen delivery (Ḋo2) after endotoxin administration, as well as the rate of fluid and protein loss from permeability-injured tissue. METHODSUnanesthetized adult sheep with lung and sof...

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Veröffentlicht in:	Critical care medicine 1991-04, Vol.19 (4), p.525-531
Hauptverfasser:	KNOX, JAMES, YOUN, YEO-KYU, LALONDE, CHERYL, DEMLING, ROBERT
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Fluids - metabolism Capillary Permeability - drug effects Catecholaminergic system Dobutamine - administration & dosage Dobutamine - pharmacology Edema - etiology Edema - physiopathology Endotoxins - blood Endotoxins - toxicity Escherichia coli Extravascular Lung Water - metabolism Female Lung - drug effects Lymph - drug effects Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Oxygen - blood Oxygen Consumption - drug effects Pharmacology. Drug treatments Proteins - metabolism Sepsis - physiopathology Sheep
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