Fat embolism syndrome complicating intraarterial chemotherapy with Cis-platinum
A 19-year-old man with telangiectatic osteosarcoma of the left proximal femur was started on a course of neoadjuvant chemotherapy consisting of intraarterial administration of cis-platinum. Within 72 hours of receiving the first intraarterial dose, the patient developed signs and symptoms of fat emb...
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| Veröffentlicht in: | Clinical orthopaedics and related research 1990-05, Vol.254 (254), p.294-297 |
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| container_title | Clinical orthopaedics and related research |
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| creator | MENENDEZ, L. R BACON, W KEMPF, R. A MOORE, T. M |
| description | A 19-year-old man with telangiectatic osteosarcoma of the left proximal femur was started on a course of neoadjuvant chemotherapy consisting of intraarterial administration of cis-platinum. Within 72 hours of receiving the first intraarterial dose, the patient developed signs and symptoms of fat embolism syndrome (FES). A physical examination revealed cyanosis, tachycardia, and seizure activity. Laboratory studies demonstrated a pO2 of less than 65 mmHg, lipuria, and a drop in hematocrit of three percentage points. There was no clinical or roentgenographic evidence of pathologic fracture. Tumor necrosis secondary to intraarterial cis-platinum therapy in this patient with osteosarcoma may have caused a sudden release of free fatty acids and embolization of fat macroglobules that precipitated this episode of FES. FES in association with the intraarterial administration of cis-platinum seems not to have been previously reported. |
| doi_str_mv | 10.1097/00003086-199005000-00044 |
| format | Article |
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R ; BACON, W ; KEMPF, R. A ; MOORE, T. M</creator><creatorcontrib>MENENDEZ, L. R ; BACON, W ; KEMPF, R. A ; MOORE, T. M</creatorcontrib><description>A 19-year-old man with telangiectatic osteosarcoma of the left proximal femur was started on a course of neoadjuvant chemotherapy consisting of intraarterial administration of cis-platinum. Within 72 hours of receiving the first intraarterial dose, the patient developed signs and symptoms of fat embolism syndrome (FES). A physical examination revealed cyanosis, tachycardia, and seizure activity. Laboratory studies demonstrated a pO2 of less than 65 mmHg, lipuria, and a drop in hematocrit of three percentage points. There was no clinical or roentgenographic evidence of pathologic fracture. Tumor necrosis secondary to intraarterial cis-platinum therapy in this patient with osteosarcoma may have caused a sudden release of free fatty acids and embolization of fat macroglobules that precipitated this episode of FES. FES in association with the intraarterial administration of cis-platinum seems not to have been previously reported.</description><identifier>ISSN: 0009-921X</identifier><identifier>EISSN: 1528-1132</identifier><identifier>DOI: 10.1097/00003086-199005000-00044</identifier><identifier>PMID: 2323145</identifier><identifier>CODEN: CORTBR</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cisplatin - administration & dosage ; Cisplatin - adverse effects ; Embolism, Fat - etiology ; Femoral Neoplasms - drug therapy ; Humans ; Infusion Pumps ; Injections, Intra-Arterial ; Male ; Medical sciences ; Osteosarcoma - drug therapy ; Syndrome</subject><ispartof>Clinical orthopaedics and related research, 1990-05, Vol.254 (254), p.294-297</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-660a0873f838f9cb16d81b419b84b428fabbbe440d6da2ad7db76fd0559fd13d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4691727$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2323145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MENENDEZ, L. R</creatorcontrib><creatorcontrib>BACON, W</creatorcontrib><creatorcontrib>KEMPF, R. A</creatorcontrib><creatorcontrib>MOORE, T. M</creatorcontrib><title>Fat embolism syndrome complicating intraarterial chemotherapy with Cis-platinum</title><title>Clinical orthopaedics and related research</title><addtitle>Clin Orthop Relat Res</addtitle><description>A 19-year-old man with telangiectatic osteosarcoma of the left proximal femur was started on a course of neoadjuvant chemotherapy consisting of intraarterial administration of cis-platinum. Within 72 hours of receiving the first intraarterial dose, the patient developed signs and symptoms of fat embolism syndrome (FES). A physical examination revealed cyanosis, tachycardia, and seizure activity. Laboratory studies demonstrated a pO2 of less than 65 mmHg, lipuria, and a drop in hematocrit of three percentage points. There was no clinical or roentgenographic evidence of pathologic fracture. Tumor necrosis secondary to intraarterial cis-platinum therapy in this patient with osteosarcoma may have caused a sudden release of free fatty acids and embolization of fat macroglobules that precipitated this episode of FES. FES in association with the intraarterial administration of cis-platinum seems not to have been previously reported.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cisplatin - administration & dosage</subject><subject>Cisplatin - adverse effects</subject><subject>Embolism, Fat - etiology</subject><subject>Femoral Neoplasms - drug therapy</subject><subject>Humans</subject><subject>Infusion Pumps</subject><subject>Injections, Intra-Arterial</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Osteosarcoma - drug therapy</subject><subject>Syndrome</subject><issn>0009-921X</issn><issn>1528-1132</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFtLAzEQhYMotVZ_gpAHX6O57W7yKMUbFPqi4NuSq41sdpckRfrv3dragWGYOefMwwcAJPieYNk84KkYFjUiUmJcTRuamvMzMCcVFYgQRs_BfLpJJCn5vARXOX_vQ7yiMzCjjDLCqzlYP6sCXdRDF3KEedfbNEQHzRDHLhhVQv8FQ1-SUqm4FFQHzcbFoWxcUuMO_oSygcuQ0djtvdt4DS686rK7Oc4F-Hh-el--otX65W35uEKGMVlQXWOFRcO8YMJLo0ltBdGcSC245lR4pbV2nGNbW0WVbaxuam9xVUlvCbNsAcThr0lDzsn5dkwhqrRrCW73iNp_RO0JUfuHaIreHqLjVkdnT8Ejk0m_O-oqG9X5pHoT8snGa0ka2rBftTVv7g</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>MENENDEZ, L. 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Vascular system</topic><topic>Cisplatin - administration & dosage</topic><topic>Cisplatin - adverse effects</topic><topic>Embolism, Fat - etiology</topic><topic>Femoral Neoplasms - drug therapy</topic><topic>Humans</topic><topic>Infusion Pumps</topic><topic>Injections, Intra-Arterial</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Osteosarcoma - drug therapy</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MENENDEZ, L. R</creatorcontrib><creatorcontrib>BACON, W</creatorcontrib><creatorcontrib>KEMPF, R. A</creatorcontrib><creatorcontrib>MOORE, T. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fat embolism syndrome complicating intraarterial chemotherapy with Cis-platinum</atitle><jtitle>Clinical orthopaedics and related research</jtitle><addtitle>Clin Orthop Relat Res</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>254</volume><issue>254</issue><spage>294</spage><epage>297</epage><pages>294-297</pages><issn>0009-921X</issn><eissn>1528-1132</eissn><coden>CORTBR</coden><abstract>A 19-year-old man with telangiectatic osteosarcoma of the left proximal femur was started on a course of neoadjuvant chemotherapy consisting of intraarterial administration of cis-platinum. Within 72 hours of receiving the first intraarterial dose, the patient developed signs and symptoms of fat embolism syndrome (FES). A physical examination revealed cyanosis, tachycardia, and seizure activity. Laboratory studies demonstrated a pO2 of less than 65 mmHg, lipuria, and a drop in hematocrit of three percentage points. There was no clinical or roentgenographic evidence of pathologic fracture. Tumor necrosis secondary to intraarterial cis-platinum therapy in this patient with osteosarcoma may have caused a sudden release of free fatty acids and embolization of fat macroglobules that precipitated this episode of FES. FES in association with the intraarterial administration of cis-platinum seems not to have been previously reported.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>2323145</pmid><doi>10.1097/00003086-199005000-00044</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical orthopaedics and related research, 1990-05, Vol.254 (254), p.294-297 |
| issn | 0009-921X 1528-1132 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cisplatin - administration & dosage Cisplatin - adverse effects Embolism, Fat - etiology Femoral Neoplasms - drug therapy Humans Infusion Pumps Injections, Intra-Arterial Male Medical sciences Osteosarcoma - drug therapy Syndrome |
| title | Fat embolism syndrome complicating intraarterial chemotherapy with Cis-platinum |
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