Comparison of the neurotoxicity of dihydroxyphenylalanine stereoisomers in cultured dopamine neurons

Oxidant stress resulting from excess dopamine (DA) may contribute to the development and progression of Parkinson's disease (PD). Free radicals resulting from the enzymatic metabolism of DA are most often discussed in this regard. However, levodopa (L-DOPA) and DA can also undergo autooxidation...

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Veröffentlicht in:	Clinical neuropharmacology 1996-08, Vol.19 (4), p.360-365
Hauptverfasser:	LING, Z.-D, PIERI, S. C, CARVEY, P. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Count - drug effects Cells, Cultured - drug effects Dihydroxyphenylalanine - pharmacology Dihydroxyphenylalanine - toxicity Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Medical sciences Neurons - drug effects Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Toxicity: nervous system and muscle
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