Evaluation of Epoxy Ether Fixed Bovine Arterial Grafts for Mutagenic Potential
Two epoxy ether compounds [glycerol polyglycidyl ether (Denacol EX-313) and ethylene glycol diglycidyl ether (Denacol EX-810)] are under consideration as alternatives to glutaraldehyde for use in the processing of an arterial graft. The two are utilized as cross-linking and sterilant agents, respect...
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| Veröffentlicht in: | ASAIO journal (1992) 1993-04, Vol.39 (2), p.106-113 |
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| container_title | ASAIO journal (1992) |
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| creator | Lohre, Jeffrey M Baclig, Lita Wickham, Emily Guida, Sarah Farley, Joanne Thyagarajan, Kalathi Tu, Roger Quijano, R C |
| description | Two epoxy ether compounds [glycerol polyglycidyl ether (Denacol EX-313) and ethylene glycol diglycidyl ether (Denacol EX-810)] are under consideration as alternatives to glutaraldehyde for use in the processing of an arterial graft. The two are utilized as cross-linking and sterilant agents, respectively. Epoxy resins are multifunctional alkylating agents, and bifunctional alkylating epoxide solutions are known to be mutagenic. The correlation between mutagenic potential and carcinogenicity, in addition to evidence that diepoxides are carcinogenic in mice and rats, prompted the evaluation of the mutagenic potential of the epoxy treated, clinically rinsed graft. Ames and sister chromatid exchange (SCE) test procedures were used to assess mutagenic potential.1ʼ2 Normal saline and distilled water were selected as the most physiologically representative and procedurally acceptable extraction mediums for the Ames and SCE tests, respectively. The results of the Ames and SCE tests in both the activated and non activated systems indicated that there were no statistically significant differences detected between various test article concentrates and the spontaneous mutation controls for both the activated and non activated systems. The epoxy treated graft was determined to be non mutagenic and demonstrated no dose related responses by these methods. |
| doi_str_mv | 10.1097/00002480-199339020-00007 |
| format | Article |
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The two are utilized as cross-linking and sterilant agents, respectively. Epoxy resins are multifunctional alkylating agents, and bifunctional alkylating epoxide solutions are known to be mutagenic. The correlation between mutagenic potential and carcinogenicity, in addition to evidence that diepoxides are carcinogenic in mice and rats, prompted the evaluation of the mutagenic potential of the epoxy treated, clinically rinsed graft. Ames and sister chromatid exchange (SCE) test procedures were used to assess mutagenic potential.1ʼ2 Normal saline and distilled water were selected as the most physiologically representative and procedurally acceptable extraction mediums for the Ames and SCE tests, respectively. The results of the Ames and SCE tests in both the activated and non activated systems indicated that there were no statistically significant differences detected between various test article concentrates and the spontaneous mutation controls for both the activated and non activated systems. The epoxy treated graft was determined to be non mutagenic and demonstrated no dose related responses by these methods.</description><identifier>ISSN: 1058-2916</identifier><identifier>EISSN: 1538-943X</identifier><identifier>DOI: 10.1097/00002480-199339020-00007</identifier><identifier>PMID: 8324256</identifier><identifier>CODEN: AJOUET</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott-Raven Publishers</publisher><subject>Animals ; Arteries - transplantation ; Biological and medical sciences ; Bioprosthesis - adverse effects ; Blood Vessel Prosthesis - adverse effects ; Cattle ; Epoxy Resins - toxicity ; Medical sciences ; Mutagenicity Tests ; Mutation ; Polypropylenes - toxicity ; Sister Chromatid Exchange ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><ispartof>ASAIO journal (1992), 1993-04, Vol.39 (2), p.106-113</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2997-ab0b9e30c3087801afc9735aa74d5cb3146e8b9e7e90b7acbb07e49ab66724183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00002480-199304000-00007$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00002480-199304000-00007$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,780,784,4609,27924,27925,64666,65461</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4758113$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8324256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lohre, Jeffrey M</creatorcontrib><creatorcontrib>Baclig, Lita</creatorcontrib><creatorcontrib>Wickham, Emily</creatorcontrib><creatorcontrib>Guida, Sarah</creatorcontrib><creatorcontrib>Farley, Joanne</creatorcontrib><creatorcontrib>Thyagarajan, Kalathi</creatorcontrib><creatorcontrib>Tu, Roger</creatorcontrib><creatorcontrib>Quijano, R C</creatorcontrib><title>Evaluation of Epoxy Ether Fixed Bovine Arterial Grafts for Mutagenic Potential</title><title>ASAIO journal (1992)</title><addtitle>ASAIO J</addtitle><description>Two epoxy ether compounds [glycerol polyglycidyl ether (Denacol EX-313) and ethylene glycol diglycidyl ether (Denacol EX-810)] are under consideration as alternatives to glutaraldehyde for use in the processing of an arterial graft. The two are utilized as cross-linking and sterilant agents, respectively. Epoxy resins are multifunctional alkylating agents, and bifunctional alkylating epoxide solutions are known to be mutagenic. The correlation between mutagenic potential and carcinogenicity, in addition to evidence that diepoxides are carcinogenic in mice and rats, prompted the evaluation of the mutagenic potential of the epoxy treated, clinically rinsed graft. Ames and sister chromatid exchange (SCE) test procedures were used to assess mutagenic potential.1ʼ2 Normal saline and distilled water were selected as the most physiologically representative and procedurally acceptable extraction mediums for the Ames and SCE tests, respectively. The results of the Ames and SCE tests in both the activated and non activated systems indicated that there were no statistically significant differences detected between various test article concentrates and the spontaneous mutation controls for both the activated and non activated systems. The epoxy treated graft was determined to be non mutagenic and demonstrated no dose related responses by these methods.</description><subject>Animals</subject><subject>Arteries - transplantation</subject><subject>Biological and medical sciences</subject><subject>Bioprosthesis - adverse effects</subject><subject>Blood Vessel Prosthesis - adverse effects</subject><subject>Cattle</subject><subject>Epoxy Resins - toxicity</subject><subject>Medical sciences</subject><subject>Mutagenicity Tests</subject><subject>Mutation</subject><subject>Polypropylenes - toxicity</subject><subject>Sister Chromatid Exchange</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><issn>1058-2916</issn><issn>1538-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctOwzAQRS0EKqXwCUhesA2MYye2l6VqC1J5LEBiF01chwbSpLLT19_j0lKJ2Xg8995ZnCGEMrhloOUdhIqFgohpzbmGGKLdSJ6QLku4irTgH6ehh0RFsWbpObnw_gsgiJx1SEfxWMRJ2iXPwxVWS2zLpqZNQYeLZrOlw3ZmHR2VGzul982qrC3tu9a6Eis6dli0nhaNo0_LFj9tXRr62rS2boN8Sc4KrLy9Orw98j4avg0eosnL-HHQn0Qm1lpGmEOuLQfDQUkFDAujJU8QpZgmJudMpFYFh7Qacokmz0FaoTFPUxkLpniPqP1e4xrvnS2yhSvn6LYZg2xHKPsjlB0J_Y5kiF7vo4tlPrfTY_CAJOg3Bx29wapwWJvSH21CJooxHmxib1s3VUDjv6vl2rpsZrFqZ9m_-4AIv_19-A_Oy30g</recordid><startdate>199304</startdate><enddate>199304</enddate><creator>Lohre, Jeffrey M</creator><creator>Baclig, Lita</creator><creator>Wickham, Emily</creator><creator>Guida, Sarah</creator><creator>Farley, Joanne</creator><creator>Thyagarajan, Kalathi</creator><creator>Tu, Roger</creator><creator>Quijano, R C</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199304</creationdate><title>Evaluation of Epoxy Ether Fixed Bovine Arterial Grafts for Mutagenic Potential</title><author>Lohre, Jeffrey M ; Baclig, Lita ; Wickham, Emily ; Guida, Sarah ; Farley, Joanne ; Thyagarajan, Kalathi ; Tu, Roger ; Quijano, R C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2997-ab0b9e30c3087801afc9735aa74d5cb3146e8b9e7e90b7acbb07e49ab66724183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Arteries - transplantation</topic><topic>Biological and medical sciences</topic><topic>Bioprosthesis - adverse effects</topic><topic>Blood Vessel Prosthesis - adverse effects</topic><topic>Cattle</topic><topic>Epoxy Resins - toxicity</topic><topic>Medical sciences</topic><topic>Mutagenicity Tests</topic><topic>Mutation</topic><topic>Polypropylenes - toxicity</topic><topic>Sister Chromatid Exchange</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lohre, Jeffrey M</creatorcontrib><creatorcontrib>Baclig, Lita</creatorcontrib><creatorcontrib>Wickham, Emily</creatorcontrib><creatorcontrib>Guida, Sarah</creatorcontrib><creatorcontrib>Farley, Joanne</creatorcontrib><creatorcontrib>Thyagarajan, Kalathi</creatorcontrib><creatorcontrib>Tu, Roger</creatorcontrib><creatorcontrib>Quijano, R C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ASAIO journal (1992)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lohre, Jeffrey M</au><au>Baclig, Lita</au><au>Wickham, Emily</au><au>Guida, Sarah</au><au>Farley, Joanne</au><au>Thyagarajan, Kalathi</au><au>Tu, Roger</au><au>Quijano, R C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Epoxy Ether Fixed Bovine Arterial Grafts for Mutagenic Potential</atitle><jtitle>ASAIO journal (1992)</jtitle><addtitle>ASAIO J</addtitle><date>1993-04</date><risdate>1993</risdate><volume>39</volume><issue>2</issue><spage>106</spage><epage>113</epage><pages>106-113</pages><issn>1058-2916</issn><eissn>1538-943X</eissn><coden>AJOUET</coden><abstract>Two epoxy ether compounds [glycerol polyglycidyl ether (Denacol EX-313) and ethylene glycol diglycidyl ether (Denacol EX-810)] are under consideration as alternatives to glutaraldehyde for use in the processing of an arterial graft. The two are utilized as cross-linking and sterilant agents, respectively. Epoxy resins are multifunctional alkylating agents, and bifunctional alkylating epoxide solutions are known to be mutagenic. The correlation between mutagenic potential and carcinogenicity, in addition to evidence that diepoxides are carcinogenic in mice and rats, prompted the evaluation of the mutagenic potential of the epoxy treated, clinically rinsed graft. Ames and sister chromatid exchange (SCE) test procedures were used to assess mutagenic potential.1ʼ2 Normal saline and distilled water were selected as the most physiologically representative and procedurally acceptable extraction mediums for the Ames and SCE tests, respectively. The results of the Ames and SCE tests in both the activated and non activated systems indicated that there were no statistically significant differences detected between various test article concentrates and the spontaneous mutation controls for both the activated and non activated systems. The epoxy treated graft was determined to be non mutagenic and demonstrated no dose related responses by these methods.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8324256</pmid><doi>10.1097/00002480-199339020-00007</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-2916 |
| ispartof | ASAIO journal (1992), 1993-04, Vol.39 (2), p.106-113 |
| issn | 1058-2916 1538-943X |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00002480_199339020_00007 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Arteries - transplantation Biological and medical sciences Bioprosthesis - adverse effects Blood Vessel Prosthesis - adverse effects Cattle Epoxy Resins - toxicity Medical sciences Mutagenicity Tests Mutation Polypropylenes - toxicity Sister Chromatid Exchange Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Evaluation of Epoxy Ether Fixed Bovine Arterial Grafts for Mutagenic Potential |
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