Lack of detectable radiation hypersensitivity in lymphoblastoid cells from multiple pedigrees of familial Alzheimer disease

Recent reports suggest that cultivated nonneuronal cells from individuals with Alzheimer disease (AD) and other specific hereditary neurodegenerative disorders show hypersensitivity to DNA-damaging agents such as x-rays and radiomimetic chemicals. The hypothesis proposed is that a number of chronic...

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Veröffentlicht in:	Alzheimer disease and associated disorders 1993, Vol.7 (2), p.88-97
Hauptverfasser:	BRYANT, E. M, BIRD, T. D, OGBURN, C. E, TRAYLOR, G. H, LAMPE, T. H, MARTIN, G. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - genetics Alzheimer Disease - pathology Biological and medical sciences Cell Line, Transformed Cell Survival - genetics Cell Survival - radiation effects Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Damage - genetics Dose-Response Relationship, Radiation Humans Medical sciences Micronucleus Tests Neurology Phenotype
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