Adaptations in skeletal muscle disuse or decreased-use atrophy

Those factors that seem to play some role in inducing adaptations of skeletal muscle in vivo are discussed. The role of myogenesis in maintaining and repairing muscle during atrophic and hypertrophic states is discussed, including pointing out that the modulation of myonuclear number is one means of...

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Veröffentlicht in:American journal of physical medicine & rehabilitation 2002-11, Vol.81 (11 Suppl), p.S127-S147
Hauptverfasser: Edgerton, V Reggie, Roy, Roland R, Allen, David L, Monti, Ryan J
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container_issue 11 Suppl
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container_title American journal of physical medicine & rehabilitation
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creator Edgerton, V Reggie
Roy, Roland R
Allen, David L
Monti, Ryan J
description Those factors that seem to play some role in inducing adaptations of skeletal muscle in vivo are discussed. The role of myogenesis in maintaining and repairing muscle during atrophic and hypertrophic states is discussed, including pointing out that the modulation of myonuclear number is one means of adapting to varying chronic levels of neuromuscular activity. Finally, we point out the potential consequences of muscle atrophy on the control of movement and the susceptibility to fatigue.
doi_str_mv 10.1097/00002060-200211001-00014
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source MEDLINE; Journals@Ovid Complete
subjects Adaptation, Physiological
Animals
Fatigue - etiology
Humans
Muscle Development
Muscle, Skeletal - metabolism
Muscular Atrophy - metabolism
Phenotype
title Adaptations in skeletal muscle disuse or decreased-use atrophy
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