Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy

Nucleoside analogue reverse transcriptase inhibitor (NRTI) therapy provides sufficient conditions for progressive subcutaneous fat wasting in HIV-infected patients. As NRTI-induced host toxicity is proposed to involve cellular mitochondrial DNA (mtDNA) depletion, determinants of cellular mtDNA copy...

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Veröffentlicht in:	AIDS (London) 2003-06, Vol.17 (9), p.1329-1338
Hauptverfasser:	NOLAN, David, HAMMOND, Emma, MARTIN, Annalise, TAYLOR, Louise, HERRMANN, Susan, MCKINNON, Elizabeth, METCALF, Cecily, LATHAM, Bruce, MALLAL, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - ultrastructure Analysis of Variance Antiretroviral Therapy, Highly Active Biological and medical sciences Case-Control Studies Cell Death Cross-Sectional Studies DNA, Mitochondrial - drug effects DNA, Mitochondrial - ultrastructure Drug toxicity and drugs side effects treatment HIV Infections - drug therapy HIV Infections - pathology HIV-Associated Lipodystrophy Syndrome - chemically induced HIV-Associated Lipodystrophy Syndrome - pathology Human viral diseases Humans Infectious diseases Medical sciences Microscopy, Electron Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - therapeutic use Reverse Transcriptase Polymerase Chain Reaction Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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