The patellazoles inhibit protein synthesis at nanomolar concentrations in human colon tumor cells

The patellazoles are a family of compounds consisting of a 24-member macrolide ring with a thiazole-epoxide tail. The opening of this epoxide does not greatly affect the bioactivity of these compounds, although the cellular toxicity is generally decreased. The patellazoles are extremely cytotoxic to...

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Veröffentlicht in:	Anti-cancer drugs 2005-06, Vol.16 (5), p.533-541
Hauptverfasser:	Richardson, Adam D, Aalbersberg, William, Ireland, Chris M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Blotting, Western Cell Cycle - drug effects Cell Line, Tumor Cell Survival - drug effects Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Dose-Response Relationship, Drug Flow Cytometry Humans Macrolides - pharmacology Nanotechnology Neoplasm Proteins - biosynthesis Oligonucleotide Array Sequence Analysis Protein Biosynthesis - drug effects RNA, Messenger - biosynthesis Structure-Activity Relationship Thiazoles - pharmacology Urochordata - chemistry
Online-Zugang:	Volltext
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