The effect of DNA-alkylating agents on gene expression from two integrated reporter genes in a mouse mammary tumor line

A model system was developed to investigate the effects of DNA alkylating agents on cellular gene expression. The cytomegalovirus immediate-early promoter (CMV) and the mouse mammary tumor virus promoter (MMTV) were coupled separately to the luciferase reporter gene and stably expressed in cultured...

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Veröffentlicht in:	Anti-cancer drugs 2002-03, Vol.13 (3), p.271-280
Hauptverfasser:	Gieseg, Michael A, de Bock, Charley, Turner, Pamela, Ferguson, Lynette R, Denny, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - pharmacology Animals Cytomegalovirus - genetics DNA Adducts - drug effects DNA, Neoplasm - drug effects Dose-Response Relationship, Drug Gene Expression - drug effects Genetic Vectors Humans Luciferases - genetics Luciferases - metabolism Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Tumor Virus, Mouse - genetics Mice RNA - antagonists & inhibitors RNA - metabolism Thymidine - metabolism Transfection
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