Percutaneous intratumoral injection of cisplatin microspheres in tumor-bearing rats to diminish acute nephrotoxicity

Poly(o,L-lactlde) microspheres loaded with cisplatin (PLA-CDDP MS) were prepared by a solvent evaporation technique for direct Intratumoral ln|ectlon. The microspheres, 50-100 |im, containing 40.04% of cisplatin produce sustained release In vitro. PLA-CDDP MS (6 mg/kg body weight of cisplatin) suspe...

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Veröffentlicht in:	Anti-cancer drugs 1996-02, Vol.7 (2), p.220-227
Hauptverfasser:	Kuang, Llren, Yang, David J, Inoue, Tomlo, Liu, William C, Wallace, Sidney, Wright, Kenneth C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Cisplatin - administration & dosage Cisplatin - pharmacology Cisplatin - toxicity Drug Carriers Drug Evaluation Injections, Intralesional Kidney - drug effects Kidney - pathology Microspheres Rats
Online-Zugang:	Volltext
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