The opioid mechanism of interferon-α action
Rats were trained to discriminate the opiold receptor agonist ethylketocyclazocine (EKC) (0.3 mg/kg body weight, intraperitoneally) from saline. Interferon-alpha (IFN-α), when substituted for EKC, ellcited a dose-related increase in EKC-like responses. This generalization of EKC responses was blocke...
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| Veröffentlicht in: | Anti-cancer drugs 1994-02, Vol.5 (1), p.90-94 |
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| container_title | Anti-cancer drugs |
| container_volume | 5 |
| creator | Ho, B T Lu, J G Huo, Y Y Fan, S H Meyers, C A Tansey, L W Payne, R Levin, V A |
| description | Rats were trained to discriminate the opiold receptor agonist ethylketocyclazocine (EKC) (0.3 mg/kg body weight, intraperitoneally) from saline. Interferon-alpha (IFN-α), when substituted for EKC, ellcited a dose-related increase in EKC-like responses. This generalization of EKC responses was blocked by the oploid antagonist naloxone (1 mg/kg). Potentiation of responses to a low dose (0.1 mg/kg) of EKC by IFN-α (1 x 10 U/kg or 0.22 nmol/kg) was also observed. Data thus indicate the involvement of opiold neurons on the action of IFN-α. d-Amphetamine (0.8 mg/kg) was shown to potentiate both EKC (0.1 mg/kg) and IFN-α (1 x 10 U/kg). The present study confirms our previously proposed opioid mediated dopaminergic mechanism of IFN-α. |
| doi_str_mv | 10.1097/00001813-199402000-00014 |
| format | Article |
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Interferon-alpha (IFN-α), when substituted for EKC, ellcited a dose-related increase in EKC-like responses. This generalization of EKC responses was blocked by the oploid antagonist naloxone (1 mg/kg). Potentiation of responses to a low dose (0.1 mg/kg) of EKC by IFN-α (1 x 10 U/kg or 0.22 nmol/kg) was also observed. Data thus indicate the involvement of opiold neurons on the action of IFN-α. d-Amphetamine (0.8 mg/kg) was shown to potentiate both EKC (0.1 mg/kg) and IFN-α (1 x 10 U/kg). The present study confirms our previously proposed opioid mediated dopaminergic mechanism of IFN-α.</description><identifier>ISSN: 0959-4973</identifier><identifier>EISSN: 1473-5741</identifier><identifier>DOI: 10.1097/00001813-199402000-00014</identifier><identifier>PMID: 8186436</identifier><language>eng</language><publisher>England: Lippincott-Raven Publishers</publisher><subject>Animals ; Dextroamphetamine - pharmacology ; Discrimination (Psychology) - drug effects ; Discrimination Learning - drug effects ; Dose-Response Relationship, Drug ; Drug Synergism ; Ethylketocyclazocine - pharmacology ; Extinction, Psychological - drug effects ; Generalization (Psychology) ; Interferon-alpha - antagonists & inhibitors ; Interferon-alpha - pharmacology ; Male ; Naloxone - pharmacology ; Rats ; Rats, Wistar ; Receptors, Opioid - drug effects</subject><ispartof>Anti-cancer drugs, 1994-02, Vol.5 (1), p.90-94</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3554-74c86ae285a6cfefbd26e012d581f8eed3414452924020c73a6a055c8d1209833</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8186436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho, B T</creatorcontrib><creatorcontrib>Lu, J G</creatorcontrib><creatorcontrib>Huo, Y Y</creatorcontrib><creatorcontrib>Fan, S H</creatorcontrib><creatorcontrib>Meyers, C A</creatorcontrib><creatorcontrib>Tansey, L W</creatorcontrib><creatorcontrib>Payne, R</creatorcontrib><creatorcontrib>Levin, V A</creatorcontrib><title>The opioid mechanism of interferon-α action</title><title>Anti-cancer drugs</title><addtitle>Anticancer Drugs</addtitle><description>Rats were trained to discriminate the opiold receptor agonist ethylketocyclazocine (EKC) (0.3 mg/kg body weight, intraperitoneally) from saline. Interferon-alpha (IFN-α), when substituted for EKC, ellcited a dose-related increase in EKC-like responses. This generalization of EKC responses was blocked by the oploid antagonist naloxone (1 mg/kg). Potentiation of responses to a low dose (0.1 mg/kg) of EKC by IFN-α (1 x 10 U/kg or 0.22 nmol/kg) was also observed. Data thus indicate the involvement of opiold neurons on the action of IFN-α. d-Amphetamine (0.8 mg/kg) was shown to potentiate both EKC (0.1 mg/kg) and IFN-α (1 x 10 U/kg). The present study confirms our previously proposed opioid mediated dopaminergic mechanism of IFN-α.</description><subject>Animals</subject><subject>Dextroamphetamine - pharmacology</subject><subject>Discrimination (Psychology) - drug effects</subject><subject>Discrimination Learning - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Ethylketocyclazocine - pharmacology</subject><subject>Extinction, Psychological - drug effects</subject><subject>Generalization (Psychology)</subject><subject>Interferon-alpha - antagonists & inhibitors</subject><subject>Interferon-alpha - pharmacology</subject><subject>Male</subject><subject>Naloxone - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Opioid - drug effects</subject><issn>0959-4973</issn><issn>1473-5741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtOwzAQhi0EKqVwBKQcAIOfib1EFS-pEpuytlxnrASSuLJbVRyLi3AmXFK6Yzaj-Wf-0XyDUEHJLSW6uiM5qKIcU60FYbnCe0WcoCkVFceyEvQUTYmWGgtd8XN0kdJ7Hsk6n6CJoqoUvJyim2UDRVi3oa2LHlxjhzb1RfBFO2wgeohhwN9fhXWbNgyX6MzbLsHVIc_Q2-PDcv6MF69PL_P7BXZcSoEr4VRpgSlpS-fBr2pWAqGslop6BVBzQYWQTLP96a7itrRESqdqyohWnM-QGve6GFKK4M06tr2Nn4YSs-c3f_zmyG9--bP1erSut6se6qPxAJz7YuzvQpcB00e33UE0Ddhu05j_3sp_AF_CY_s</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>Ho, B T</creator><creator>Lu, J G</creator><creator>Huo, Y Y</creator><creator>Fan, S H</creator><creator>Meyers, C A</creator><creator>Tansey, L W</creator><creator>Payne, R</creator><creator>Levin, V A</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199402</creationdate><title>The opioid mechanism of interferon-α action</title><author>Ho, B T ; Lu, J G ; Huo, Y Y ; Fan, S H ; Meyers, C A ; Tansey, L W ; Payne, R ; Levin, V A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3554-74c86ae285a6cfefbd26e012d581f8eed3414452924020c73a6a055c8d1209833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Dextroamphetamine - pharmacology</topic><topic>Discrimination (Psychology) - drug effects</topic><topic>Discrimination Learning - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>Ethylketocyclazocine - pharmacology</topic><topic>Extinction, Psychological - drug effects</topic><topic>Generalization (Psychology)</topic><topic>Interferon-alpha - antagonists & inhibitors</topic><topic>Interferon-alpha - pharmacology</topic><topic>Male</topic><topic>Naloxone - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Opioid - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, B T</creatorcontrib><creatorcontrib>Lu, J G</creatorcontrib><creatorcontrib>Huo, Y Y</creatorcontrib><creatorcontrib>Fan, S H</creatorcontrib><creatorcontrib>Meyers, C A</creatorcontrib><creatorcontrib>Tansey, L W</creatorcontrib><creatorcontrib>Payne, R</creatorcontrib><creatorcontrib>Levin, V A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Anti-cancer drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, B T</au><au>Lu, J G</au><au>Huo, Y Y</au><au>Fan, S H</au><au>Meyers, C A</au><au>Tansey, L W</au><au>Payne, R</au><au>Levin, V A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The opioid mechanism of interferon-α action</atitle><jtitle>Anti-cancer drugs</jtitle><addtitle>Anticancer Drugs</addtitle><date>1994-02</date><risdate>1994</risdate><volume>5</volume><issue>1</issue><spage>90</spage><epage>94</epage><pages>90-94</pages><issn>0959-4973</issn><eissn>1473-5741</eissn><abstract>Rats were trained to discriminate the opiold receptor agonist ethylketocyclazocine (EKC) (0.3 mg/kg body weight, intraperitoneally) from saline. Interferon-alpha (IFN-α), when substituted for EKC, ellcited a dose-related increase in EKC-like responses. This generalization of EKC responses was blocked by the oploid antagonist naloxone (1 mg/kg). Potentiation of responses to a low dose (0.1 mg/kg) of EKC by IFN-α (1 x 10 U/kg or 0.22 nmol/kg) was also observed. Data thus indicate the involvement of opiold neurons on the action of IFN-α. d-Amphetamine (0.8 mg/kg) was shown to potentiate both EKC (0.1 mg/kg) and IFN-α (1 x 10 U/kg). The present study confirms our previously proposed opioid mediated dopaminergic mechanism of IFN-α.</abstract><cop>England</cop><pub>Lippincott-Raven Publishers</pub><pmid>8186436</pmid><doi>10.1097/00001813-199402000-00014</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4973 |
| ispartof | Anti-cancer drugs, 1994-02, Vol.5 (1), p.90-94 |
| issn | 0959-4973 1473-5741 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Dextroamphetamine - pharmacology Discrimination (Psychology) - drug effects Discrimination Learning - drug effects Dose-Response Relationship, Drug Drug Synergism Ethylketocyclazocine - pharmacology Extinction, Psychological - drug effects Generalization (Psychology) Interferon-alpha - antagonists & inhibitors Interferon-alpha - pharmacology Male Naloxone - pharmacology Rats Rats, Wistar Receptors, Opioid - drug effects |
| title | The opioid mechanism of interferon-α action |
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