Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas
Glutamine (Gln) is a growth determinant in neoplastic tissues. We analysed by RT-PCR the expression of mRNAs coding for the human variants of Gln transportersASCT2 (system ASC), SNAT1 [ATA1] (system A), SNAT3 [SN1] and SNAT5 [SN2] (system N), in samples of human malignant gliomas WHO grades III/IV (...
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| Veröffentlicht in: | Neuroreport 2004-03, Vol.15 (4), p.575-578 |
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| creator | Sidoryk, Marta Matyja, Ewa Dybel, Anna Zielinska, Magdalena Bogucki, Jacek Jaskólski, Dariusz J Liberski, Pawel P Kowalczyk, Pawel Albrecht, Jan |
| description | Glutamine (Gln) is a growth determinant in neoplastic tissues. We analysed by RT-PCR the expression of mRNAs coding for the human variants of Gln transportersASCT2 (system ASC), SNAT1 [ATA1] (system A), SNAT3 [SN1] and SNAT5 [SN2] (system N), in samples of human malignant gliomas WHO grades III/IV (anaplastic astrocytoma and glioblastoma), glioma-derived cell cultures, brain metastases from peripheral organs, and control brain tissue. (Transporters designated according to the nomenclature recently proposed by Mckenzie and Ericksson []. Original designations in square brackets.) SNAT3 mRNA showed a 3–5 times stronger expression in gliomas than in metastases or control tissue, and was virtually absent from glioma cultures. Native glioblastoma immunostained positively with anti-SNAT3 antibody. The expression of ASCT2 mRNA, but not SNAT5 or SNAT1 mRNAs, was increased in all neoplastic tissues studied. Hence, increased expression of SNAT3 is a marker of primary malignant gliomas in situ. |
| doi_str_mv | 10.1097/00001756-200403220-00001 |
| format | Article |
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We analysed by RT-PCR the expression of mRNAs coding for the human variants of Gln transportersASCT2 (system ASC), SNAT1 [ATA1] (system A), SNAT3 [SN1] and SNAT5 [SN2] (system N), in samples of human malignant gliomas WHO grades III/IV (anaplastic astrocytoma and glioblastoma), glioma-derived cell cultures, brain metastases from peripheral organs, and control brain tissue. (Transporters designated according to the nomenclature recently proposed by Mckenzie and Ericksson []. Original designations in square brackets.) SNAT3 mRNA showed a 3–5 times stronger expression in gliomas than in metastases or control tissue, and was virtually absent from glioma cultures. Native glioblastoma immunostained positively with anti-SNAT3 antibody. The expression of ASCT2 mRNA, but not SNAT5 or SNAT1 mRNAs, was increased in all neoplastic tissues studied. Hence, increased expression of SNAT3 is a marker of primary malignant gliomas in situ.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200403220-00001</identifier><identifier>PMID: 15094455</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Amino Acid Transport System A - genetics ; Amino Acid Transport System ASC - genetics ; Amino Acid Transport Systems, Neutral - genetics ; Amino Acid Transport Systems, Neutral - metabolism ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Brain Neoplasms - diagnosis ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Fundamental and applied biological sciences. Psychology ; Glioma - diagnosis ; Glioma - metabolism ; Glioma - pathology ; Humans ; Immunohistochemistry ; Medical sciences ; Minor Histocompatibility Antigens ; Neurology ; Predictive Value of Tests ; Reproducibility of Results ; RNA, Messenger - metabolism ; Tumor Cells, Cultured ; Tumors of the nervous system. Phacomatoses ; Up-Regulation - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2004-03, Vol.15 (4), p.575-578</ispartof><rights>2004 Lippincott Williams & Wilkins, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4521-ed9ffcd731d5dfa6db8af9e7f3233f41ae07fbe309ea531a6368e4d0185d17c03</citedby><cites>FETCH-LOGICAL-c4521-ed9ffcd731d5dfa6db8af9e7f3233f41ae07fbe309ea531a6368e4d0185d17c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15927072$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15094455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sidoryk, Marta</creatorcontrib><creatorcontrib>Matyja, Ewa</creatorcontrib><creatorcontrib>Dybel, Anna</creatorcontrib><creatorcontrib>Zielinska, Magdalena</creatorcontrib><creatorcontrib>Bogucki, Jacek</creatorcontrib><creatorcontrib>Jaskólski, Dariusz J</creatorcontrib><creatorcontrib>Liberski, Pawel P</creatorcontrib><creatorcontrib>Kowalczyk, Pawel</creatorcontrib><creatorcontrib>Albrecht, Jan</creatorcontrib><title>Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Glutamine (Gln) is a growth determinant in neoplastic tissues. We analysed by RT-PCR the expression of mRNAs coding for the human variants of Gln transportersASCT2 (system ASC), SNAT1 [ATA1] (system A), SNAT3 [SN1] and SNAT5 [SN2] (system N), in samples of human malignant gliomas WHO grades III/IV (anaplastic astrocytoma and glioblastoma), glioma-derived cell cultures, brain metastases from peripheral organs, and control brain tissue. (Transporters designated according to the nomenclature recently proposed by Mckenzie and Ericksson []. Original designations in square brackets.) SNAT3 mRNA showed a 3–5 times stronger expression in gliomas than in metastases or control tissue, and was virtually absent from glioma cultures. Native glioblastoma immunostained positively with anti-SNAT3 antibody. The expression of ASCT2 mRNA, but not SNAT5 or SNAT1 mRNAs, was increased in all neoplastic tissues studied. Hence, increased expression of SNAT3 is a marker of primary malignant gliomas in situ.</description><subject>Amino Acid Transport System A - genetics</subject><subject>Amino Acid Transport System ASC - genetics</subject><subject>Amino Acid Transport Systems, Neutral - genetics</subject><subject>Amino Acid Transport Systems, Neutral - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glioma - diagnosis</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Minor Histocompatibility Antigens</subject><subject>Neurology</subject><subject>Predictive Value of Tests</subject><subject>Reproducibility of Results</subject><subject>RNA, Messenger - metabolism</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Up-Regulation - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOwzAQRS0EoqXwCygblgE7tuN4WVU8KlWwoCB20TQet6F5VHaqwt9jSHls8Gakq3NH9jEhEaOXjGp1RcNhSqZxQqmgPElo_BUdkCETisdSZi-HZEi11LHQqRyQE-9fA6Epy47JgEmqhZBySJ6nTeEQPJoI3zYOvS_bJmptBNGy2nZQlw1GnYPGb1rXoYse78dzHpU-ADW4dUgCXENVLhtoulAq2xr8KTmyUHk8288Rebq5nk_u4tnD7XQynsWFkAmL0WhrC6M4M9JYSM0iA6tRWZ5wbgUDpMoukFONIDmDlKcZChMeIQ1TBeUjkvV7C9d679DmG1eGe73njOafqvJvVfmPqj4K1fO-utkuajS_xb2bAFzsAfAFVDZIKEr_h9OJoioJnOi5XVsFQ35dbXfo8hVC1a3y_76KfwC1ZYFZ</recordid><startdate>20040322</startdate><enddate>20040322</enddate><creator>Sidoryk, Marta</creator><creator>Matyja, Ewa</creator><creator>Dybel, Anna</creator><creator>Zielinska, Magdalena</creator><creator>Bogucki, Jacek</creator><creator>Jaskólski, Dariusz J</creator><creator>Liberski, Pawel P</creator><creator>Kowalczyk, Pawel</creator><creator>Albrecht, Jan</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20040322</creationdate><title>Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas</title><author>Sidoryk, Marta ; Matyja, Ewa ; Dybel, Anna ; Zielinska, Magdalena ; Bogucki, Jacek ; Jaskólski, Dariusz J ; Liberski, Pawel P ; Kowalczyk, Pawel ; Albrecht, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4521-ed9ffcd731d5dfa6db8af9e7f3233f41ae07fbe309ea531a6368e4d0185d17c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amino Acid Transport System A - genetics</topic><topic>Amino Acid Transport System ASC - genetics</topic><topic>Amino Acid Transport Systems, Neutral - genetics</topic><topic>Amino Acid Transport Systems, Neutral - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glioma - diagnosis</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Minor Histocompatibility Antigens</topic><topic>Neurology</topic><topic>Predictive Value of Tests</topic><topic>Reproducibility of Results</topic><topic>RNA, Messenger - metabolism</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Up-Regulation - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sidoryk, Marta</creatorcontrib><creatorcontrib>Matyja, Ewa</creatorcontrib><creatorcontrib>Dybel, Anna</creatorcontrib><creatorcontrib>Zielinska, Magdalena</creatorcontrib><creatorcontrib>Bogucki, Jacek</creatorcontrib><creatorcontrib>Jaskólski, Dariusz J</creatorcontrib><creatorcontrib>Liberski, Pawel P</creatorcontrib><creatorcontrib>Kowalczyk, Pawel</creatorcontrib><creatorcontrib>Albrecht, Jan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sidoryk, Marta</au><au>Matyja, Ewa</au><au>Dybel, Anna</au><au>Zielinska, Magdalena</au><au>Bogucki, Jacek</au><au>Jaskólski, Dariusz J</au><au>Liberski, Pawel P</au><au>Kowalczyk, Pawel</au><au>Albrecht, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2004-03-22</date><risdate>2004</risdate><volume>15</volume><issue>4</issue><spage>575</spage><epage>578</epage><pages>575-578</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Glutamine (Gln) is a growth determinant in neoplastic tissues. We analysed by RT-PCR the expression of mRNAs coding for the human variants of Gln transportersASCT2 (system ASC), SNAT1 [ATA1] (system A), SNAT3 [SN1] and SNAT5 [SN2] (system N), in samples of human malignant gliomas WHO grades III/IV (anaplastic astrocytoma and glioblastoma), glioma-derived cell cultures, brain metastases from peripheral organs, and control brain tissue. (Transporters designated according to the nomenclature recently proposed by Mckenzie and Ericksson []. Original designations in square brackets.) SNAT3 mRNA showed a 3–5 times stronger expression in gliomas than in metastases or control tissue, and was virtually absent from glioma cultures. Native glioblastoma immunostained positively with anti-SNAT3 antibody. The expression of ASCT2 mRNA, but not SNAT5 or SNAT1 mRNAs, was increased in all neoplastic tissues studied. Hence, increased expression of SNAT3 is a marker of primary malignant gliomas in situ.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15094455</pmid><doi>10.1097/00001756-200403220-00001</doi><tpages>4</tpages></addata></record> |
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| subjects | Amino Acid Transport System A - genetics Amino Acid Transport System ASC - genetics Amino Acid Transport Systems, Neutral - genetics Amino Acid Transport Systems, Neutral - metabolism Biological and medical sciences Biomarkers, Tumor - metabolism Brain Neoplasms - diagnosis Brain Neoplasms - metabolism Brain Neoplasms - pathology Fundamental and applied biological sciences. Psychology Glioma - diagnosis Glioma - metabolism Glioma - pathology Humans Immunohistochemistry Medical sciences Minor Histocompatibility Antigens Neurology Predictive Value of Tests Reproducibility of Results RNA, Messenger - metabolism Tumor Cells, Cultured Tumors of the nervous system. Phacomatoses Up-Regulation - physiology Vertebrates: nervous system and sense organs |
| title | Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas |
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