The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia

Nociceptin/orphanin FQ (NC) and its receptor (OP4) represent a novel peptide/receptor system which has been implicated in the regulation of various central functions, including pain. The aim of the present study was to explore the involvement of the endogenous NC/OP4 system in the modulation of opio...

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Veröffentlicht in:	Neuroreport 2000-08, Vol.11 (11), p.2369-2372
Hauptverfasser:	Rizzi, Anna, Bigoni, Raffaella, Marzola, Giuliano, Guerrini, Remo, Salvadori, Severo, Regoli, Domenico, Calo, Girolamo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Animals Biological and medical sciences Central Nervous System - drug effects Central Nervous System - metabolism Dose-Response Relationship, Drug Drug Interactions - physiology Drug Tolerance - physiology Fundamental and applied biological sciences. Psychology Male Mice Morphine - pharmacology Narcotic Antagonists Nociceptin Nociceptin Receptor Opioid Peptides - drug effects Opioid Peptides - metabolism Opioid Peptides - pharmacology Pain - drug therapy Pain - physiopathology Pain Measurement - drug effects Peptide Fragments - pharmacology Reaction Time - drug effects Receptors, Opioid - metabolism Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs
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