The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia
Nociceptin/orphanin FQ (NC) and its receptor (OP4) represent a novel peptide/receptor system which has been implicated in the regulation of various central functions, including pain. The aim of the present study was to explore the involvement of the endogenous NC/OP4 system in the modulation of opio...
Gespeichert in:
| Veröffentlicht in: | Neuroreport 2000-08, Vol.11 (11), p.2369-2372 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2372 |
|---|---|
| container_issue | 11 |
| container_start_page | 2369 |
| container_title | Neuroreport |
| container_volume | 11 |
| creator | Rizzi, Anna Bigoni, Raffaella Marzola, Giuliano Guerrini, Remo Salvadori, Severo Regoli, Domenico Calo, Girolamo |
| description | Nociceptin/orphanin FQ (NC) and its receptor (OP4) represent a novel peptide/receptor system which has been implicated in the regulation of various central functions, including pain. The aim of the present study was to explore the involvement of the endogenous NC/OP4 system in the modulation of opioid analgesia using the selective OP4 receptor antagonist [Nphe1]NC(1–13)NH2. Experiments were performed in mice exposed to acute as well as chronic treatment with morphine. [Nphe1]NC(1–13)NH2, injected i.c.v. at 30 nmol, strongly potentiated the analgesic effect of supraspinal morphine (1 nmol, i.c.v.) while it only slightly increased the antinociceptive activity of morphine given systemically (5 mg/kg, s.c.). [Nphe1]NC(1–13)NH, (30 nmol, i.c.v.) also potentiated morphine analgesia in mice made tolerant to the opiate (30 mg/kg/day for 4 days). These findings implicate the endogenous NC signaling as a modulator of morphine analgesia and tolerance. |
| doi_str_mv | 10.1097/00001756-200008030-00007 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00001756_200008030_00007</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10943687</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3857-3c1e7e37a86cf01d234da40eab935fc22199b567432754888df89e72d26b6b973</originalsourceid><addsrcrecordid>eNp1kUtLxDAUhYMozjj6F6QLFwrWyaNpkqUMjgrDiKAgiJQ0vZ1GO2lJKuK_t3V8bbybezl85yzORSgi-IxgJaa4HyJ4GtPhkpjheDjEFhqTRLCYc_mwjcZYcRUnKuUjtBfCc08oTOQuGvUhCUulGKP8roLINcYaaDvrpo1vK-2si-a3kYdBbHykXadXjbOhO40el20F5Gk5OyYxYSfLK3oatU0HrrO6gxCthwTroDfpegXB6n20U-o6wMHXnqD7-cXd7Cpe3Fxez84XsWGSi5gZAgKY0DI1JSYFZUmhEww6V4yXhlKiVM5TkTAqeCKlLEqpQNCCpnmaK8EmSG5yjW9C8FBmrbdr7d8zgrOhtuy7tuyntk9psB5urO1rvobij3HTUw8cfQE6GF2XXjtjwy_HKWeM91iywd6augMfXurXN_BZBbruquy_r7EP2IyDJA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Rizzi, Anna ; Bigoni, Raffaella ; Marzola, Giuliano ; Guerrini, Remo ; Salvadori, Severo ; Regoli, Domenico ; Calo, Girolamo</creator><creatorcontrib>Rizzi, Anna ; Bigoni, Raffaella ; Marzola, Giuliano ; Guerrini, Remo ; Salvadori, Severo ; Regoli, Domenico ; Calo, Girolamo</creatorcontrib><description>Nociceptin/orphanin FQ (NC) and its receptor (OP4) represent a novel peptide/receptor system which has been implicated in the regulation of various central functions, including pain. The aim of the present study was to explore the involvement of the endogenous NC/OP4 system in the modulation of opioid analgesia using the selective OP4 receptor antagonist [Nphe1]NC(1–13)NH2. Experiments were performed in mice exposed to acute as well as chronic treatment with morphine. [Nphe1]NC(1–13)NH2, injected i.c.v. at 30 nmol, strongly potentiated the analgesic effect of supraspinal morphine (1 nmol, i.c.v.) while it only slightly increased the antinociceptive activity of morphine given systemically (5 mg/kg, s.c.). [Nphe1]NC(1–13)NH, (30 nmol, i.c.v.) also potentiated morphine analgesia in mice made tolerant to the opiate (30 mg/kg/day for 4 days). These findings implicate the endogenous NC signaling as a modulator of morphine analgesia and tolerance.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200008030-00007</identifier><identifier>PMID: 10943687</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Analgesia ; Animals ; Biological and medical sciences ; Central Nervous System - drug effects ; Central Nervous System - metabolism ; Dose-Response Relationship, Drug ; Drug Interactions - physiology ; Drug Tolerance - physiology ; Fundamental and applied biological sciences. Psychology ; Male ; Mice ; Morphine - pharmacology ; Narcotic Antagonists ; Nociceptin ; Nociceptin Receptor ; Opioid Peptides - drug effects ; Opioid Peptides - metabolism ; Opioid Peptides - pharmacology ; Pain - drug therapy ; Pain - physiopathology ; Pain Measurement - drug effects ; Peptide Fragments - pharmacology ; Reaction Time - drug effects ; Receptors, Opioid - metabolism ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2000-08, Vol.11 (11), p.2369-2372</ispartof><rights>2000 Lippincott Williams & Wilkins, Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3857-3c1e7e37a86cf01d234da40eab935fc22199b567432754888df89e72d26b6b973</citedby><cites>FETCH-LOGICAL-c3857-3c1e7e37a86cf01d234da40eab935fc22199b567432754888df89e72d26b6b973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1525335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10943687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rizzi, Anna</creatorcontrib><creatorcontrib>Bigoni, Raffaella</creatorcontrib><creatorcontrib>Marzola, Giuliano</creatorcontrib><creatorcontrib>Guerrini, Remo</creatorcontrib><creatorcontrib>Salvadori, Severo</creatorcontrib><creatorcontrib>Regoli, Domenico</creatorcontrib><creatorcontrib>Calo, Girolamo</creatorcontrib><title>The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Nociceptin/orphanin FQ (NC) and its receptor (OP4) represent a novel peptide/receptor system which has been implicated in the regulation of various central functions, including pain. The aim of the present study was to explore the involvement of the endogenous NC/OP4 system in the modulation of opioid analgesia using the selective OP4 receptor antagonist [Nphe1]NC(1–13)NH2. Experiments were performed in mice exposed to acute as well as chronic treatment with morphine. [Nphe1]NC(1–13)NH2, injected i.c.v. at 30 nmol, strongly potentiated the analgesic effect of supraspinal morphine (1 nmol, i.c.v.) while it only slightly increased the antinociceptive activity of morphine given systemically (5 mg/kg, s.c.). [Nphe1]NC(1–13)NH, (30 nmol, i.c.v.) also potentiated morphine analgesia in mice made tolerant to the opiate (30 mg/kg/day for 4 days). These findings implicate the endogenous NC signaling as a modulator of morphine analgesia and tolerance.</description><subject>Analgesia</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System - drug effects</subject><subject>Central Nervous System - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions - physiology</subject><subject>Drug Tolerance - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Mice</subject><subject>Morphine - pharmacology</subject><subject>Narcotic Antagonists</subject><subject>Nociceptin</subject><subject>Nociceptin Receptor</subject><subject>Opioid Peptides - drug effects</subject><subject>Opioid Peptides - metabolism</subject><subject>Opioid Peptides - pharmacology</subject><subject>Pain - drug therapy</subject><subject>Pain - physiopathology</subject><subject>Pain Measurement - drug effects</subject><subject>Peptide Fragments - pharmacology</subject><subject>Reaction Time - drug effects</subject><subject>Receptors, Opioid - metabolism</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLxDAUhYMozjj6F6QLFwrWyaNpkqUMjgrDiKAgiJQ0vZ1GO2lJKuK_t3V8bbybezl85yzORSgi-IxgJaa4HyJ4GtPhkpjheDjEFhqTRLCYc_mwjcZYcRUnKuUjtBfCc08oTOQuGvUhCUulGKP8roLINcYaaDvrpo1vK-2si-a3kYdBbHykXadXjbOhO40el20F5Gk5OyYxYSfLK3oatU0HrrO6gxCthwTroDfpegXB6n20U-o6wMHXnqD7-cXd7Cpe3Fxez84XsWGSi5gZAgKY0DI1JSYFZUmhEww6V4yXhlKiVM5TkTAqeCKlLEqpQNCCpnmaK8EmSG5yjW9C8FBmrbdr7d8zgrOhtuy7tuyntk9psB5urO1rvobij3HTUw8cfQE6GF2XXjtjwy_HKWeM91iywd6augMfXurXN_BZBbruquy_r7EP2IyDJA</recordid><startdate>20000803</startdate><enddate>20000803</enddate><creator>Rizzi, Anna</creator><creator>Bigoni, Raffaella</creator><creator>Marzola, Giuliano</creator><creator>Guerrini, Remo</creator><creator>Salvadori, Severo</creator><creator>Regoli, Domenico</creator><creator>Calo, Girolamo</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20000803</creationdate><title>The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia</title><author>Rizzi, Anna ; Bigoni, Raffaella ; Marzola, Giuliano ; Guerrini, Remo ; Salvadori, Severo ; Regoli, Domenico ; Calo, Girolamo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3857-3c1e7e37a86cf01d234da40eab935fc22199b567432754888df89e72d26b6b973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analgesia</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System - drug effects</topic><topic>Central Nervous System - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions - physiology</topic><topic>Drug Tolerance - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Mice</topic><topic>Morphine - pharmacology</topic><topic>Narcotic Antagonists</topic><topic>Nociceptin</topic><topic>Nociceptin Receptor</topic><topic>Opioid Peptides - drug effects</topic><topic>Opioid Peptides - metabolism</topic><topic>Opioid Peptides - pharmacology</topic><topic>Pain - drug therapy</topic><topic>Pain - physiopathology</topic><topic>Pain Measurement - drug effects</topic><topic>Peptide Fragments - pharmacology</topic><topic>Reaction Time - drug effects</topic><topic>Receptors, Opioid - metabolism</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rizzi, Anna</creatorcontrib><creatorcontrib>Bigoni, Raffaella</creatorcontrib><creatorcontrib>Marzola, Giuliano</creatorcontrib><creatorcontrib>Guerrini, Remo</creatorcontrib><creatorcontrib>Salvadori, Severo</creatorcontrib><creatorcontrib>Regoli, Domenico</creatorcontrib><creatorcontrib>Calo, Girolamo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizzi, Anna</au><au>Bigoni, Raffaella</au><au>Marzola, Giuliano</au><au>Guerrini, Remo</au><au>Salvadori, Severo</au><au>Regoli, Domenico</au><au>Calo, Girolamo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2000-08-03</date><risdate>2000</risdate><volume>11</volume><issue>11</issue><spage>2369</spage><epage>2372</epage><pages>2369-2372</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Nociceptin/orphanin FQ (NC) and its receptor (OP4) represent a novel peptide/receptor system which has been implicated in the regulation of various central functions, including pain. The aim of the present study was to explore the involvement of the endogenous NC/OP4 system in the modulation of opioid analgesia using the selective OP4 receptor antagonist [Nphe1]NC(1–13)NH2. Experiments were performed in mice exposed to acute as well as chronic treatment with morphine. [Nphe1]NC(1–13)NH2, injected i.c.v. at 30 nmol, strongly potentiated the analgesic effect of supraspinal morphine (1 nmol, i.c.v.) while it only slightly increased the antinociceptive activity of morphine given systemically (5 mg/kg, s.c.). [Nphe1]NC(1–13)NH, (30 nmol, i.c.v.) also potentiated morphine analgesia in mice made tolerant to the opiate (30 mg/kg/day for 4 days). These findings implicate the endogenous NC signaling as a modulator of morphine analgesia and tolerance.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10943687</pmid><doi>10.1097/00001756-200008030-00007</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 2000-08, Vol.11 (11), p.2369-2372 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00001756_200008030_00007 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Analgesia Animals Biological and medical sciences Central Nervous System - drug effects Central Nervous System - metabolism Dose-Response Relationship, Drug Drug Interactions - physiology Drug Tolerance - physiology Fundamental and applied biological sciences. Psychology Male Mice Morphine - pharmacology Narcotic Antagonists Nociceptin Nociceptin Receptor Opioid Peptides - drug effects Opioid Peptides - metabolism Opioid Peptides - pharmacology Pain - drug therapy Pain - physiopathology Pain Measurement - drug effects Peptide Fragments - pharmacology Reaction Time - drug effects Receptors, Opioid - metabolism Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T11%3A41%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20nociceptin/orphanin%20FQ%20receptor%20antagonist,%20%5BNphe1%5DNC(1-13)NH2,%20potentiates%20morphine%20analgesia&rft.jtitle=Neuroreport&rft.au=Rizzi,%20Anna&rft.date=2000-08-03&rft.volume=11&rft.issue=11&rft.spage=2369&rft.epage=2372&rft.pages=2369-2372&rft.issn=0959-4965&rft.eissn=1473-558X&rft_id=info:doi/10.1097/00001756-200008030-00007&rft_dat=%3Cpubmed_cross%3E10943687%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/10943687&rfr_iscdi=true |