Enhanced acetylcholine release in striatum after chronic amphetamine is NMDA-dependent

BEHAVIORAL sensitization to chronic amphetamine develops in parallel with an enhancement of amphetamine-stimulated efflux of acetylcholine (ACh) in striatum. The present study investigated the role of NMDA receptors in the latter phenomenon. Rats were treated with either saline (1.0 ml/kg, i.p.) or...

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Veröffentlicht in:	Neuroreport 1999-01, Vol.10 (1), p.77-80
Hauptverfasser:	Bickerdike, Michael J, Abercrombie, Elizabeth D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Amphetamine - adverse effects Animals Biological and medical sciences Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine Agonists - adverse effects Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - physiology Substance Withdrawal Syndrome Time Factors
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