cAMP potentiates β-amyloid-induced nitric oxide release from microglia

THE β-amyloid peptide (Aβ) has been known to activate microglia and to induce release of nitric oxide (NO). In this study, we examined the effect of cAMP on Aβ-induced microglial activation using cultured rat brain microglia. Dibutyryl-cAMP (dbcAMP) and 3-isobutyl-1-methylxanthine (IBMX) significant...

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Veröffentlicht in:	Neuroreport 1999-01, Vol.10 (1), p.37-39
Hauptverfasser:	Pyo, Hankyoung, Jou, Ilo, Jung, Soyoung, Joe, Eunhye
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology Adenylyl Cyclases - drug effects Amyloid beta-Peptides - pharmacology Animals Biological and medical sciences Bucladesine - pharmacology Cells, Cultured Colforsin - pharmacology Cyclic AMP - pharmacology Drug Synergism Enzyme Activation Fundamental and applied biological sciences. Psychology Isolated neuron and nerve. Neuroglia Microglia - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs
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