Chronic ethanol retards kindling of hippocampal area CA3
TO investigate the effects of chronic alcohol which persist long after cessation of ethanol exposure, electrical kindling of the hippocampus was studied in male Sprague–Dawley rats chronically exposed to ethanol. Kindling was initiated 14 days after either one continuous period of ethanol exposure,...
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| Veröffentlicht in: | Neuroreport 1997-05, Vol.8 (8), p.1903-1906 |
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| creator | Veatch, L M Gonzalez, L P |
| description | TO investigate the effects of chronic alcohol which persist long after cessation of ethanol exposure, electrical kindling of the hippocampus was studied in male Sprague–Dawley rats chronically exposed to ethanol. Kindling was initiated 14 days after either one continuous period of ethanol exposure, repeated periods of exposure and withdrawal, or control handling. Animals receiving ethanol exposure required significantly more stimulations to develop behavioral signs of kindling and to attain final kindling criterion than did ethanol-naive controls. Neither the blood ethanol level at the time of withdrawal nor the behavioral signs of acute withdrawal severity correlated with kindling measures. This study indicates that chronic ethanol exposure results in brain alterations which may be assessed long after the cessation of ethanol exposure. |
| doi_str_mv | 10.1097/00001756-199705260-00022 |
| format | Article |
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Kindling was initiated 14 days after either one continuous period of ethanol exposure, repeated periods of exposure and withdrawal, or control handling. Animals receiving ethanol exposure required significantly more stimulations to develop behavioral signs of kindling and to attain final kindling criterion than did ethanol-naive controls. Neither the blood ethanol level at the time of withdrawal nor the behavioral signs of acute withdrawal severity correlated with kindling measures. This study indicates that chronic ethanol exposure results in brain alterations which may be assessed long after the cessation of ethanol exposure.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9223074</pmid><doi>10.1097/00001756-199705260-00022</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 1997-05, Vol.8 (8), p.1903-1906 |
| issn | 0959-4965 1473-558X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Administration, Inhalation Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - adverse effects Central Nervous System Depressants - pharmacology Electric Stimulation Ethanol - administration & dosage Ethanol - adverse effects Ethanol - pharmacology Hippocampus - drug effects Hippocampus - physiology Kindling, Neurologic - drug effects Kindling, Neurologic - physiology Male Medical sciences Rats Rats, Sprague-Dawley Substance Withdrawal Syndrome - physiopathology Toxicology |
| title | Chronic ethanol retards kindling of hippocampal area CA3 |
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