Nicotine modulates the neurotoxic effect of β-amyloid protein(25–35) in hippocampal cultures

TWO major features of Alzheimerʼs disease (AD) are b-amyloid protein (βAP) deposition and a severe cholinergic deficit. An association between the two is suggested by the negative correlation found between cigarette smoking and AD. We sought to investigate this further by examining the effects of ac...

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Veröffentlicht in:	Neuroreport 1997-01, Vol.8 (2), p.513-517
Hauptverfasser:	Zamani, M Reza, Allen, Yvonne S, Owen, Gill P, Gray, Jeffrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - toxicity Animals Biological and medical sciences Cells, Cultured - drug effects Dose-Response Relationship, Drug Hippocampus - drug effects Medical sciences Neuropharmacology Neuroprotective agent Nicotine - pharmacology Pharmacology. Drug treatments Rats Rats, Wistar
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