Polychlorinated Biphenyl (PCB) Exposure in Relation to Thyroid Hormone Levels in Neonates
Polychlorinated biphenyls (PCBs) are industrially produced environmentally persistent compounds. In developed countries all humans have detectable levels in blood and other tissues. PCBs alter thyroid hormone metabolism in animal experiments, and human data suggest background-level exposure may have...
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| Veröffentlicht in: | Epidemiology (Cambridge, Mass.) Mass.), 2000-05, Vol.11 (3), p.249-254 |
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| creator | Longnecker, Matthew P. Gladen, Beth C. Patterson, Donald G. Rogan, Walter J. |
| description | Polychlorinated biphenyls (PCBs) are industrially produced environmentally persistent compounds. In developed countries all humans have detectable levels in blood and other tissues. PCBs alter thyroid hormone metabolism in animal experiments, and human data suggest background-level exposure may have similar effects in neonates. We evaluated this possible effect among 160 North Carolina children whose in utero PCB exposure was estimated on the basis of the mother's PCB levels in milk and blood, in 1978-1982 (estimated median PCB level in milk at birth, 1.8 mg/kg lipid). Their umbilical cord sera were thawed in 1998 and assayed for total thyroxine, free thyroxine, and thyroid stimulating hormone. We found that PCB exposure was not strongly related to any of the thyroid measures. For example, for a one unit change in milk PCB concentration (mg/kg lipid), the associated multivariate-adjusted increase in thyroid stimulating hormone level was 7% (95% confidence limits (CL) = -6, 21). Despite the possibility of sample degradation, these data suggest that within the range of background-level exposure in the United States, in utero PCB exposure is only slightly related to serum concentration of total thyroxine, free thyroxine, and thyroid stimulating hormone at birth. |
| doi_str_mv | 10.1097/00001648-200005000-00004 |
| format | Article |
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In developed countries all humans have detectable levels in blood and other tissues. PCBs alter thyroid hormone metabolism in animal experiments, and human data suggest background-level exposure may have similar effects in neonates. We evaluated this possible effect among 160 North Carolina children whose in utero PCB exposure was estimated on the basis of the mother's PCB levels in milk and blood, in 1978-1982 (estimated median PCB level in milk at birth, 1.8 mg/kg lipid). Their umbilical cord sera were thawed in 1998 and assayed for total thyroxine, free thyroxine, and thyroid stimulating hormone. We found that PCB exposure was not strongly related to any of the thyroid measures. For example, for a one unit change in milk PCB concentration (mg/kg lipid), the associated multivariate-adjusted increase in thyroid stimulating hormone level was 7% (95% confidence limits (CL) = -6, 21). Despite the possibility of sample degradation, these data suggest that within the range of background-level exposure in the United States, in utero PCB exposure is only slightly related to serum concentration of total thyroxine, free thyroxine, and thyroid stimulating hormone at birth.</description><identifier>ISSN: 1044-3983</identifier><identifier>EISSN: 1531-5487</identifier><identifier>DOI: 10.1097/00001648-200005000-00004</identifier><identifier>PMID: 10784239</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins</publisher><subject>Adult ; Air. Soil. Water. Waste. Feeding ; Biological and medical sciences ; Breast milk ; Chemical hazards ; Congeners ; Environment. Living conditions ; Environmental Pollutants ; Female ; Fetal Blood - chemistry ; Hormone metabolism ; Hormones ; Humans ; Infant, Newborn ; Lipids ; Male ; Maternal Exposure ; Medical sciences ; Milk, Human - chemistry ; Newborns ; Polychlorinated Biphenyls ; Public health. 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In developed countries all humans have detectable levels in blood and other tissues. PCBs alter thyroid hormone metabolism in animal experiments, and human data suggest background-level exposure may have similar effects in neonates. We evaluated this possible effect among 160 North Carolina children whose in utero PCB exposure was estimated on the basis of the mother's PCB levels in milk and blood, in 1978-1982 (estimated median PCB level in milk at birth, 1.8 mg/kg lipid). Their umbilical cord sera were thawed in 1998 and assayed for total thyroxine, free thyroxine, and thyroid stimulating hormone. We found that PCB exposure was not strongly related to any of the thyroid measures. For example, for a one unit change in milk PCB concentration (mg/kg lipid), the associated multivariate-adjusted increase in thyroid stimulating hormone level was 7% (95% confidence limits (CL) = -6, 21). Despite the possibility of sample degradation, these data suggest that within the range of background-level exposure in the United States, in utero PCB exposure is only slightly related to serum concentration of total thyroxine, free thyroxine, and thyroid stimulating hormone at birth.</description><subject>Adult</subject><subject>Air. Soil. Water. Waste. Feeding</subject><subject>Biological and medical sciences</subject><subject>Breast milk</subject><subject>Chemical hazards</subject><subject>Congeners</subject><subject>Environment. Living conditions</subject><subject>Environmental Pollutants</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Hormone metabolism</subject><subject>Hormones</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Lipids</subject><subject>Male</subject><subject>Maternal Exposure</subject><subject>Medical sciences</subject><subject>Milk, Human - chemistry</subject><subject>Newborns</subject><subject>Polychlorinated Biphenyls</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Thyroid Gland - physiology</subject><subject>Thyroid hormones</subject><subject>Thyrotropin - analysis</subject><subject>Thyroxine - analysis</subject><subject>Umbilical cord</subject><issn>1044-3983</issn><issn>1531-5487</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUlPwzAUhC0Eomz_ACEfOMAhYMdrj1CxSRUgVA6cItd5UVLcuLJToP-ehJTlgiXLI3u-0dMYIUzJGSVDdU7aRSXXSdop0e6kE3wD7VDBaCK4VputJpwnbKjZAO3GOGsZxajYRgNKlOYpG-6gl0fvVrZ0PlS1aSDHl9WihHrl8Mnj6PIUX30sfFwGwFWNn8CZpvI1bjyelKvgqxzf-jD3NeAxvIGLnesefJcU99FWYVyEg_W5h56vryaj22T8cHM3uhgnlgvJEysEDHMhC10oJaZ5rosUtErl1ErGZSGYkTy1CqSGXKZWWm0VJd2bZNoytod0n2uDjzFAkS1CNTdhlVGSdW1l321lP219XfEWPerRxXI6h_wP2NfTGo7XBhOtcUUwta3ir49JqXQ3Au9t7941EOKrW75DyEowrimz_z6rxQ57bBYbH35SmSIsJZp9Akt7idg</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Longnecker, Matthew P.</creator><creator>Gladen, Beth C.</creator><creator>Patterson, Donald G.</creator><creator>Rogan, Walter J.</creator><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200005</creationdate><title>Polychlorinated Biphenyl (PCB) Exposure in Relation to Thyroid Hormone Levels in Neonates</title><author>Longnecker, Matthew P. ; Gladen, Beth C. ; Patterson, Donald G. ; Rogan, Walter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4564-c55e9d56f8f775bdd8f2e8726bc6346f53a642c7e68ed62c6c8c7106346638c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Air. Soil. Water. Waste. Feeding</topic><topic>Biological and medical sciences</topic><topic>Breast milk</topic><topic>Chemical hazards</topic><topic>Congeners</topic><topic>Environment. Living conditions</topic><topic>Environmental Pollutants</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Hormone metabolism</topic><topic>Hormones</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Lipids</topic><topic>Male</topic><topic>Maternal Exposure</topic><topic>Medical sciences</topic><topic>Milk, Human - chemistry</topic><topic>Newborns</topic><topic>Polychlorinated Biphenyls</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Thyroid Gland - physiology</topic><topic>Thyroid hormones</topic><topic>Thyrotropin - analysis</topic><topic>Thyroxine - analysis</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Longnecker, Matthew P.</creatorcontrib><creatorcontrib>Gladen, Beth C.</creatorcontrib><creatorcontrib>Patterson, Donald G.</creatorcontrib><creatorcontrib>Rogan, Walter J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Epidemiology (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Longnecker, Matthew P.</au><au>Gladen, Beth C.</au><au>Patterson, Donald G.</au><au>Rogan, Walter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polychlorinated Biphenyl (PCB) Exposure in Relation to Thyroid Hormone Levels in Neonates</atitle><jtitle>Epidemiology (Cambridge, Mass.)</jtitle><addtitle>Epidemiology</addtitle><date>2000-05</date><risdate>2000</risdate><volume>11</volume><issue>3</issue><spage>249</spage><epage>254</epage><pages>249-254</pages><issn>1044-3983</issn><eissn>1531-5487</eissn><abstract>Polychlorinated biphenyls (PCBs) are industrially produced environmentally persistent compounds. In developed countries all humans have detectable levels in blood and other tissues. PCBs alter thyroid hormone metabolism in animal experiments, and human data suggest background-level exposure may have similar effects in neonates. We evaluated this possible effect among 160 North Carolina children whose in utero PCB exposure was estimated on the basis of the mother's PCB levels in milk and blood, in 1978-1982 (estimated median PCB level in milk at birth, 1.8 mg/kg lipid). Their umbilical cord sera were thawed in 1998 and assayed for total thyroxine, free thyroxine, and thyroid stimulating hormone. We found that PCB exposure was not strongly related to any of the thyroid measures. For example, for a one unit change in milk PCB concentration (mg/kg lipid), the associated multivariate-adjusted increase in thyroid stimulating hormone level was 7% (95% confidence limits (CL) = -6, 21). Despite the possibility of sample degradation, these data suggest that within the range of background-level exposure in the United States, in utero PCB exposure is only slightly related to serum concentration of total thyroxine, free thyroxine, and thyroid stimulating hormone at birth.</abstract><cop>Philadelphia, PA</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10784239</pmid><doi>10.1097/00001648-200005000-00004</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete; JSTOR Archive Collection A-Z Listing |
| subjects | Adult Air. Soil. Water. Waste. Feeding Biological and medical sciences Breast milk Chemical hazards Congeners Environment. Living conditions Environmental Pollutants Female Fetal Blood - chemistry Hormone metabolism Hormones Humans Infant, Newborn Lipids Male Maternal Exposure Medical sciences Milk, Human - chemistry Newborns Polychlorinated Biphenyls Public health. Hygiene Public health. Hygiene-occupational medicine Thyroid Gland - physiology Thyroid hormones Thyrotropin - analysis Thyroxine - analysis Umbilical cord |
| title | Polychlorinated Biphenyl (PCB) Exposure in Relation to Thyroid Hormone Levels in Neonates |
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