Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients
Preoperative alteration of T cell-mediated immunity as well as an altered immune response to surgical stress were found in long-term alcoholic patients. The aim of this study was to evaluate perioperative T cell-mediated immune parameters as well as cytokine release from whole blood cells after lipo...
Gespeichert in:
| Veröffentlicht in: | Anesthesiology (Philadelphia) 2004-05, Vol.100 (5), p.1088-1100 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1100 |
|---|---|
| container_issue | 5 |
| container_start_page | 1088 |
| container_title | Anesthesiology (Philadelphia) |
| container_volume | 100 |
| creator | SPIES, Claudia D VON DOSSOW, Vera PASCHEN, Christian MIRSALIM, Parwis BRUNSCH, Ralf HOPF, Jürgen MARKS, Christian WERNECKE, Klaus-D PRAGST, Fritz EHRENREICH, Hannelore MÜLLER, Christian TONNESEN, Hanne EGGERS, Verena OELKERS, Wolfgang ROHDE, Wolfgang STEIN, Christoph KOX, Wolfgang J JETSCHMANN, Gesine EL-HILALI, Ratiba EGERT, Julia FISCHER, Marc SCHRÖDER, Torsten HÖFLICH, Conny SINHA, Pranav |
| description | Preoperative alteration of T cell-mediated immunity as well as an altered immune response to surgical stress were found in long-term alcoholic patients. The aim of this study was to evaluate perioperative T cell-mediated immune parameters as well as cytokine release from whole blood cells after lipopolysaccharide stimulation and its association with postoperative infections.
Fifty-four patients undergoing elective surgery of the aerodigestive tract were included in this prospective observational study. Long-term alcoholic patients (n = 31) were defined as having a daily ethanol consumption of at least 60 g and fulfilling the Diagnostic and Statistical Manual of Mental Disorders for either alcohol abuse or alcohol dependence. The nonalcoholic patients (n = 23) were defined as drinking less than 60 g ethanol/day. Blood samples to analyze the immune status were obtained on morning before surgery and on the morning of days 1, 3, and 5 after surgery.
Basic patient characteristics did not differ between groups. Before surgery, the T helper 1:T helper 2 ratio (Th1: Th2) was significantly lower (P < 0.01), whereas plasma interleukin 1beta and lipopolysaccharide-stimulated interleukin 1ra from whole blood cells were increased in long-term alcoholic patients. After surgery, a significant suppression of the cytotoxic lymphocyte ratio (Tc1:Tc2), the interferon gamma:interleukin 10 ratio from lipopolysaccharide-stimulated whole blood cells, and a significant increase of plasma interleukin 10 was observed. Long-term alcoholics had more frequent postoperative infections compared with nonalcoholic patients (54%vs. 26%; P = 0.03).
T helper cell-mediated immunity was significantly suppressed before surgery and possibly led to inadequate cytotoxic lymphocyte and whole blood cell response in long-term alcoholic patients after surgery. This altered cell-mediated immunity might have accounted for the increased infection rate in long-term alcoholic patients after surgery. |
| doi_str_mv | 10.1097/00000542-200405000-00010 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00000542_200405000_00010</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15114205</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-3ccae44052b39adf1ac9d04f1b22b6d4e4e19076c3b9f1fa31dab92611e573983</originalsourceid><addsrcrecordid>eNpNkEtLAzEUhYMotlb_gszGZTQ3j85kWYovENzoeshkEo1kJkOSCv33prY-LoTLOZxzIR9CFZBrILK-IbsRnGJKCCeiCFwekCM0B0EbDFCLYzQvHsOMUDpDZyl9FFkL1pyiGQgATomYI7fy2UTTV9p4jwfTO5WLcsOwGV3eVmosYtTRqFTsKaQcJhNVdp-m-Nbo7MJYFWMnKx_GN1zuDZXyOrwH73Q1lbAZczpHJ1b5ZC4Oe4Fe725f1g_46fn-cb16wpoLmTHTWhlePkU7JlVvQWnZE26ho7Rb9txwA5LUS806acEqBr3qJF0CGFEz2bAFavZ3dQwpRWPbKbpBxW0LpN3Ra3_otb_02m96pXq5r06brqD4Kx5wlcDVIaCSVt5GNWqX_uVqDoLV7Asy_Hlb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>SPIES, Claudia D ; VON DOSSOW, Vera ; PASCHEN, Christian ; MIRSALIM, Parwis ; BRUNSCH, Ralf ; HOPF, Jürgen ; MARKS, Christian ; WERNECKE, Klaus-D ; PRAGST, Fritz ; EHRENREICH, Hannelore ; MÜLLER, Christian ; TONNESEN, Hanne ; EGGERS, Verena ; OELKERS, Wolfgang ; ROHDE, Wolfgang ; STEIN, Christoph ; KOX, Wolfgang J ; JETSCHMANN, Gesine ; EL-HILALI, Ratiba ; EGERT, Julia ; FISCHER, Marc ; SCHRÖDER, Torsten ; HÖFLICH, Conny ; SINHA, Pranav</creator><creatorcontrib>SPIES, Claudia D ; VON DOSSOW, Vera ; PASCHEN, Christian ; MIRSALIM, Parwis ; BRUNSCH, Ralf ; HOPF, Jürgen ; MARKS, Christian ; WERNECKE, Klaus-D ; PRAGST, Fritz ; EHRENREICH, Hannelore ; MÜLLER, Christian ; TONNESEN, Hanne ; EGGERS, Verena ; OELKERS, Wolfgang ; ROHDE, Wolfgang ; STEIN, Christoph ; KOX, Wolfgang J ; JETSCHMANN, Gesine ; EL-HILALI, Ratiba ; EGERT, Julia ; FISCHER, Marc ; SCHRÖDER, Torsten ; HÖFLICH, Conny ; SINHA, Pranav</creatorcontrib><description>Preoperative alteration of T cell-mediated immunity as well as an altered immune response to surgical stress were found in long-term alcoholic patients. The aim of this study was to evaluate perioperative T cell-mediated immune parameters as well as cytokine release from whole blood cells after lipopolysaccharide stimulation and its association with postoperative infections.
Fifty-four patients undergoing elective surgery of the aerodigestive tract were included in this prospective observational study. Long-term alcoholic patients (n = 31) were defined as having a daily ethanol consumption of at least 60 g and fulfilling the Diagnostic and Statistical Manual of Mental Disorders for either alcohol abuse or alcohol dependence. The nonalcoholic patients (n = 23) were defined as drinking less than 60 g ethanol/day. Blood samples to analyze the immune status were obtained on morning before surgery and on the morning of days 1, 3, and 5 after surgery.
Basic patient characteristics did not differ between groups. Before surgery, the T helper 1:T helper 2 ratio (Th1: Th2) was significantly lower (P < 0.01), whereas plasma interleukin 1beta and lipopolysaccharide-stimulated interleukin 1ra from whole blood cells were increased in long-term alcoholic patients. After surgery, a significant suppression of the cytotoxic lymphocyte ratio (Tc1:Tc2), the interferon gamma:interleukin 10 ratio from lipopolysaccharide-stimulated whole blood cells, and a significant increase of plasma interleukin 10 was observed. Long-term alcoholics had more frequent postoperative infections compared with nonalcoholic patients (54%vs. 26%; P = 0.03).
T helper cell-mediated immunity was significantly suppressed before surgery and possibly led to inadequate cytotoxic lymphocyte and whole blood cell response in long-term alcoholic patients after surgery. This altered cell-mediated immunity might have accounted for the increased infection rate in long-term alcoholic patients after surgery.</description><identifier>ISSN: 0003-3022</identifier><identifier>EISSN: 1528-1175</identifier><identifier>DOI: 10.1097/00000542-200405000-00010</identifier><identifier>PMID: 15114205</identifier><identifier>CODEN: ANESAV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Alcoholism - drug therapy ; Alcoholism - immunology ; Alcoholism - surgery ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antibiotic Prophylaxis ; Biological and medical sciences ; Cefuroxime - pharmacology ; Cefuroxime - therapeutic use ; Cytokines - metabolism ; Female ; Humans ; Immunity, Cellular - drug effects ; Male ; Medical sciences ; Metronidazole - pharmacology ; Metronidazole - therapeutic use ; Middle Aged ; Postoperative Complications - drug therapy ; Postoperative Complications - immunology ; Prospective Studies ; Surgical Wound Infection - drug therapy ; Surgical Wound Infection - immunology ; Th1 Cells - drug effects ; Th1 Cells - immunology ; Th2 Cells - drug effects ; Th2 Cells - immunology</subject><ispartof>Anesthesiology (Philadelphia), 2004-05, Vol.100 (5), p.1088-1100</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-3ccae44052b39adf1ac9d04f1b22b6d4e4e19076c3b9f1fa31dab92611e573983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15741537$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15114205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SPIES, Claudia D</creatorcontrib><creatorcontrib>VON DOSSOW, Vera</creatorcontrib><creatorcontrib>PASCHEN, Christian</creatorcontrib><creatorcontrib>MIRSALIM, Parwis</creatorcontrib><creatorcontrib>BRUNSCH, Ralf</creatorcontrib><creatorcontrib>HOPF, Jürgen</creatorcontrib><creatorcontrib>MARKS, Christian</creatorcontrib><creatorcontrib>WERNECKE, Klaus-D</creatorcontrib><creatorcontrib>PRAGST, Fritz</creatorcontrib><creatorcontrib>EHRENREICH, Hannelore</creatorcontrib><creatorcontrib>MÜLLER, Christian</creatorcontrib><creatorcontrib>TONNESEN, Hanne</creatorcontrib><creatorcontrib>EGGERS, Verena</creatorcontrib><creatorcontrib>OELKERS, Wolfgang</creatorcontrib><creatorcontrib>ROHDE, Wolfgang</creatorcontrib><creatorcontrib>STEIN, Christoph</creatorcontrib><creatorcontrib>KOX, Wolfgang J</creatorcontrib><creatorcontrib>JETSCHMANN, Gesine</creatorcontrib><creatorcontrib>EL-HILALI, Ratiba</creatorcontrib><creatorcontrib>EGERT, Julia</creatorcontrib><creatorcontrib>FISCHER, Marc</creatorcontrib><creatorcontrib>SCHRÖDER, Torsten</creatorcontrib><creatorcontrib>HÖFLICH, Conny</creatorcontrib><creatorcontrib>SINHA, Pranav</creatorcontrib><title>Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients</title><title>Anesthesiology (Philadelphia)</title><addtitle>Anesthesiology</addtitle><description>Preoperative alteration of T cell-mediated immunity as well as an altered immune response to surgical stress were found in long-term alcoholic patients. The aim of this study was to evaluate perioperative T cell-mediated immune parameters as well as cytokine release from whole blood cells after lipopolysaccharide stimulation and its association with postoperative infections.
Fifty-four patients undergoing elective surgery of the aerodigestive tract were included in this prospective observational study. Long-term alcoholic patients (n = 31) were defined as having a daily ethanol consumption of at least 60 g and fulfilling the Diagnostic and Statistical Manual of Mental Disorders for either alcohol abuse or alcohol dependence. The nonalcoholic patients (n = 23) were defined as drinking less than 60 g ethanol/day. Blood samples to analyze the immune status were obtained on morning before surgery and on the morning of days 1, 3, and 5 after surgery.
Basic patient characteristics did not differ between groups. Before surgery, the T helper 1:T helper 2 ratio (Th1: Th2) was significantly lower (P < 0.01), whereas plasma interleukin 1beta and lipopolysaccharide-stimulated interleukin 1ra from whole blood cells were increased in long-term alcoholic patients. After surgery, a significant suppression of the cytotoxic lymphocyte ratio (Tc1:Tc2), the interferon gamma:interleukin 10 ratio from lipopolysaccharide-stimulated whole blood cells, and a significant increase of plasma interleukin 10 was observed. Long-term alcoholics had more frequent postoperative infections compared with nonalcoholic patients (54%vs. 26%; P = 0.03).
T helper cell-mediated immunity was significantly suppressed before surgery and possibly led to inadequate cytotoxic lymphocyte and whole blood cell response in long-term alcoholic patients after surgery. This altered cell-mediated immunity might have accounted for the increased infection rate in long-term alcoholic patients after surgery.</description><subject>Alcoholism - drug therapy</subject><subject>Alcoholism - immunology</subject><subject>Alcoholism - surgery</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antibiotic Prophylaxis</subject><subject>Biological and medical sciences</subject><subject>Cefuroxime - pharmacology</subject><subject>Cefuroxime - therapeutic use</subject><subject>Cytokines - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity, Cellular - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metronidazole - pharmacology</subject><subject>Metronidazole - therapeutic use</subject><subject>Middle Aged</subject><subject>Postoperative Complications - drug therapy</subject><subject>Postoperative Complications - immunology</subject><subject>Prospective Studies</subject><subject>Surgical Wound Infection - drug therapy</subject><subject>Surgical Wound Infection - immunology</subject><subject>Th1 Cells - drug effects</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - drug effects</subject><subject>Th2 Cells - immunology</subject><issn>0003-3022</issn><issn>1528-1175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLAzEUhYMotlb_gszGZTQ3j85kWYovENzoeshkEo1kJkOSCv33prY-LoTLOZxzIR9CFZBrILK-IbsRnGJKCCeiCFwekCM0B0EbDFCLYzQvHsOMUDpDZyl9FFkL1pyiGQgATomYI7fy2UTTV9p4jwfTO5WLcsOwGV3eVmosYtTRqFTsKaQcJhNVdp-m-Nbo7MJYFWMnKx_GN1zuDZXyOrwH73Q1lbAZczpHJ1b5ZC4Oe4Fe725f1g_46fn-cb16wpoLmTHTWhlePkU7JlVvQWnZE26ho7Rb9txwA5LUS806acEqBr3qJF0CGFEz2bAFavZ3dQwpRWPbKbpBxW0LpN3Ra3_otb_02m96pXq5r06brqD4Kx5wlcDVIaCSVt5GNWqX_uVqDoLV7Asy_Hlb</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>SPIES, Claudia D</creator><creator>VON DOSSOW, Vera</creator><creator>PASCHEN, Christian</creator><creator>MIRSALIM, Parwis</creator><creator>BRUNSCH, Ralf</creator><creator>HOPF, Jürgen</creator><creator>MARKS, Christian</creator><creator>WERNECKE, Klaus-D</creator><creator>PRAGST, Fritz</creator><creator>EHRENREICH, Hannelore</creator><creator>MÜLLER, Christian</creator><creator>TONNESEN, Hanne</creator><creator>EGGERS, Verena</creator><creator>OELKERS, Wolfgang</creator><creator>ROHDE, Wolfgang</creator><creator>STEIN, Christoph</creator><creator>KOX, Wolfgang J</creator><creator>JETSCHMANN, Gesine</creator><creator>EL-HILALI, Ratiba</creator><creator>EGERT, Julia</creator><creator>FISCHER, Marc</creator><creator>SCHRÖDER, Torsten</creator><creator>HÖFLICH, Conny</creator><creator>SINHA, Pranav</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20040501</creationdate><title>Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients</title><author>SPIES, Claudia D ; VON DOSSOW, Vera ; PASCHEN, Christian ; MIRSALIM, Parwis ; BRUNSCH, Ralf ; HOPF, Jürgen ; MARKS, Christian ; WERNECKE, Klaus-D ; PRAGST, Fritz ; EHRENREICH, Hannelore ; MÜLLER, Christian ; TONNESEN, Hanne ; EGGERS, Verena ; OELKERS, Wolfgang ; ROHDE, Wolfgang ; STEIN, Christoph ; KOX, Wolfgang J ; JETSCHMANN, Gesine ; EL-HILALI, Ratiba ; EGERT, Julia ; FISCHER, Marc ; SCHRÖDER, Torsten ; HÖFLICH, Conny ; SINHA, Pranav</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-3ccae44052b39adf1ac9d04f1b22b6d4e4e19076c3b9f1fa31dab92611e573983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alcoholism - drug therapy</topic><topic>Alcoholism - immunology</topic><topic>Alcoholism - surgery</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antibiotic Prophylaxis</topic><topic>Biological and medical sciences</topic><topic>Cefuroxime - pharmacology</topic><topic>Cefuroxime - therapeutic use</topic><topic>Cytokines - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunity, Cellular - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metronidazole - pharmacology</topic><topic>Metronidazole - therapeutic use</topic><topic>Middle Aged</topic><topic>Postoperative Complications - drug therapy</topic><topic>Postoperative Complications - immunology</topic><topic>Prospective Studies</topic><topic>Surgical Wound Infection - drug therapy</topic><topic>Surgical Wound Infection - immunology</topic><topic>Th1 Cells - drug effects</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SPIES, Claudia D</creatorcontrib><creatorcontrib>VON DOSSOW, Vera</creatorcontrib><creatorcontrib>PASCHEN, Christian</creatorcontrib><creatorcontrib>MIRSALIM, Parwis</creatorcontrib><creatorcontrib>BRUNSCH, Ralf</creatorcontrib><creatorcontrib>HOPF, Jürgen</creatorcontrib><creatorcontrib>MARKS, Christian</creatorcontrib><creatorcontrib>WERNECKE, Klaus-D</creatorcontrib><creatorcontrib>PRAGST, Fritz</creatorcontrib><creatorcontrib>EHRENREICH, Hannelore</creatorcontrib><creatorcontrib>MÜLLER, Christian</creatorcontrib><creatorcontrib>TONNESEN, Hanne</creatorcontrib><creatorcontrib>EGGERS, Verena</creatorcontrib><creatorcontrib>OELKERS, Wolfgang</creatorcontrib><creatorcontrib>ROHDE, Wolfgang</creatorcontrib><creatorcontrib>STEIN, Christoph</creatorcontrib><creatorcontrib>KOX, Wolfgang J</creatorcontrib><creatorcontrib>JETSCHMANN, Gesine</creatorcontrib><creatorcontrib>EL-HILALI, Ratiba</creatorcontrib><creatorcontrib>EGERT, Julia</creatorcontrib><creatorcontrib>FISCHER, Marc</creatorcontrib><creatorcontrib>SCHRÖDER, Torsten</creatorcontrib><creatorcontrib>HÖFLICH, Conny</creatorcontrib><creatorcontrib>SINHA, Pranav</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Anesthesiology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SPIES, Claudia D</au><au>VON DOSSOW, Vera</au><au>PASCHEN, Christian</au><au>MIRSALIM, Parwis</au><au>BRUNSCH, Ralf</au><au>HOPF, Jürgen</au><au>MARKS, Christian</au><au>WERNECKE, Klaus-D</au><au>PRAGST, Fritz</au><au>EHRENREICH, Hannelore</au><au>MÜLLER, Christian</au><au>TONNESEN, Hanne</au><au>EGGERS, Verena</au><au>OELKERS, Wolfgang</au><au>ROHDE, Wolfgang</au><au>STEIN, Christoph</au><au>KOX, Wolfgang J</au><au>JETSCHMANN, Gesine</au><au>EL-HILALI, Ratiba</au><au>EGERT, Julia</au><au>FISCHER, Marc</au><au>SCHRÖDER, Torsten</au><au>HÖFLICH, Conny</au><au>SINHA, Pranav</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients</atitle><jtitle>Anesthesiology (Philadelphia)</jtitle><addtitle>Anesthesiology</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>100</volume><issue>5</issue><spage>1088</spage><epage>1100</epage><pages>1088-1100</pages><issn>0003-3022</issn><eissn>1528-1175</eissn><coden>ANESAV</coden><abstract>Preoperative alteration of T cell-mediated immunity as well as an altered immune response to surgical stress were found in long-term alcoholic patients. The aim of this study was to evaluate perioperative T cell-mediated immune parameters as well as cytokine release from whole blood cells after lipopolysaccharide stimulation and its association with postoperative infections.
Fifty-four patients undergoing elective surgery of the aerodigestive tract were included in this prospective observational study. Long-term alcoholic patients (n = 31) were defined as having a daily ethanol consumption of at least 60 g and fulfilling the Diagnostic and Statistical Manual of Mental Disorders for either alcohol abuse or alcohol dependence. The nonalcoholic patients (n = 23) were defined as drinking less than 60 g ethanol/day. Blood samples to analyze the immune status were obtained on morning before surgery and on the morning of days 1, 3, and 5 after surgery.
Basic patient characteristics did not differ between groups. Before surgery, the T helper 1:T helper 2 ratio (Th1: Th2) was significantly lower (P < 0.01), whereas plasma interleukin 1beta and lipopolysaccharide-stimulated interleukin 1ra from whole blood cells were increased in long-term alcoholic patients. After surgery, a significant suppression of the cytotoxic lymphocyte ratio (Tc1:Tc2), the interferon gamma:interleukin 10 ratio from lipopolysaccharide-stimulated whole blood cells, and a significant increase of plasma interleukin 10 was observed. Long-term alcoholics had more frequent postoperative infections compared with nonalcoholic patients (54%vs. 26%; P = 0.03).
T helper cell-mediated immunity was significantly suppressed before surgery and possibly led to inadequate cytotoxic lymphocyte and whole blood cell response in long-term alcoholic patients after surgery. This altered cell-mediated immunity might have accounted for the increased infection rate in long-term alcoholic patients after surgery.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>15114205</pmid><doi>10.1097/00000542-200405000-00010</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-3022 |
| ispartof | Anesthesiology (Philadelphia), 2004-05, Vol.100 (5), p.1088-1100 |
| issn | 0003-3022 1528-1175 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00000542_200405000_00010 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Alcoholism - drug therapy Alcoholism - immunology Alcoholism - surgery Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibiotic Prophylaxis Biological and medical sciences Cefuroxime - pharmacology Cefuroxime - therapeutic use Cytokines - metabolism Female Humans Immunity, Cellular - drug effects Male Medical sciences Metronidazole - pharmacology Metronidazole - therapeutic use Middle Aged Postoperative Complications - drug therapy Postoperative Complications - immunology Prospective Studies Surgical Wound Infection - drug therapy Surgical Wound Infection - immunology Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology |
| title | Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T08%3A43%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Altered%20cell-mediated%20immunity%20and%20increased%20postoperative%20infection%20rate%20in%20long-term%20alcoholic%20patients&rft.jtitle=Anesthesiology%20(Philadelphia)&rft.au=SPIES,%20Claudia%20D&rft.date=2004-05-01&rft.volume=100&rft.issue=5&rft.spage=1088&rft.epage=1100&rft.pages=1088-1100&rft.issn=0003-3022&rft.eissn=1528-1175&rft.coden=ANESAV&rft_id=info:doi/10.1097/00000542-200405000-00010&rft_dat=%3Cpubmed_cross%3E15114205%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/15114205&rfr_iscdi=true |