The influence of hemorrhagic shock on propofol: A pharmacokinetic and pharmacodynamic analysis

Propofol is a common sedative hypnotic for the induction and maintenance of anesthesia. Clinicians typically moderate the dose of propofol or choose a different sedative hypnotic in the setting of severe intravascular volume depletion. Previous work has established that hemorrhagic shock influences...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2003-08, Vol.99 (2), p.409-420
Hauptverfasser:	JOHNSON, Ken B, EGAN, Talmage D, KERN, Steven E, WHITE, Julia L, MCJAMES, Scott W, SYROID, Noah, WHIDDON, Derek, CHURCH, Ty
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis of Variance Anesthesia Anesthetics, Inhalation - pharmacology Anesthetics, Intravenous - pharmacokinetics Anesthetics, Intravenous - pharmacology Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Blood Glucose - metabolism Blood Pressure - drug effects Computer Simulation Female Heart Rate - drug effects Isoflurane - pharmacology Lactic Acid - blood Male Medical sciences Neuropharmacology Nonlinear Dynamics Pharmacology. Drug treatments Pilot Projects Propofol - pharmacokinetics Propofol - pharmacology Shock, Hemorrhagic - physiopathology Swine
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