Prolonged regional nerve blockade : Injectable biodegradable bupivacaine/polyester microspheres

Biodegradable microspheres are a useful method of drug delivery because they are both injectable and biodegradable, eliminating the need for surgical implantation or removal. Previous work has characterized implantable preparations of local anesthetics in polymer pellets for prolonged regional anest...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1996-06, Vol.84 (6), p.1401-1410
Hauptverfasser:	CURLEY, J, CASTILLO, J, HOTZ, J, UEZONO, M, HERNANDEZ, S, LIM, J.-O, TIGNER, J, CHASIN, M, LANGER, R, BERDE, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Local - administration & dosage Anesthetics. Neuromuscular blocking agents Animals Biodegradation, Environmental Biological and medical sciences Bupivacaine - administration & dosage Dexamethasone - pharmacology Injections Lactic Acid Male Medical sciences Microspheres Nerve Block Neuropharmacology Pharmacology. Drug treatments Polyglycolic Acid Polylactic Acid-Polyglycolic Acid Copolymer Polymers - administration & dosage Rats Rats, Sprague-Dawley Sciatic Nerve - drug effects Time Factors
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