Protamine-heparin-induced pulmonary hypertension in pigs : effects of treatment with a thromboxane receptor antagonist on hemodynamics and coagulation

Adverse hemodynamic reactions after protamine neutralization of heparin are an infrequent but important clinical problem. Pre-treatment of swine with a thromboxane A2 receptor antagonist has been reported to prevent the pulmonary hypertensive response occasionally seen after protamine reversal of he...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1991, Vol.74 (1), p.138-145
Hauptverfasser:	NUTTALL, G. A, MURRAY, M. J, BOWIE, E. J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bleeding Time Blood Coagulation - drug effects Blood. Blood coagulation. Reticuloendothelial system Carbazoles - pharmacology Carbazoles - therapeutic use Hemodynamics - drug effects Heparin - toxicity Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - drug therapy Male Medical sciences Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Protamines - toxicity Receptors, Prostaglandin - drug effects Receptors, Thromboxane Swine Thromboxanes - antagonists & inhibitors Thromboxanes - physiology
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