Dexmedetomidine fails to cause hyperalgesia after cessation of chronic administration

Hyperalgesia occurring after the cessation of chronic opioid administration occurs in humans and has been modeled in rodents with chronic systemic and intrathecal administration paradigms. It is, however, unclear if this type of postanalgesic hyperalgesia is unique to opioids. The alpha(2)-adrenergi...

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Veröffentlicht in:	Anesthesia and analgesia 2003, Vol.96 (1), p.195-200
Hauptverfasser:	DAVIES, M. Frances, HAIMOR, Fawzi, LIGHTHALL, Geoffrey, CLARK, J. David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - physiology Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists - adverse effects Analgesics Analgesics, Opioid - pharmacology Animals Behavior, Animal - drug effects Biological and medical sciences Dexmedetomidine - adverse effects Dose-Response Relationship, Drug Hot Temperature Hyperalgesia - chemically induced Hyperalgesia - psychology Ion Channels - drug effects Male Medical sciences Mice Mice, Inbred C57BL Morphine - pharmacology Neuropharmacology Pain Threshold - drug effects Pharmacology. Drug treatments Physical Stimulation Substance Withdrawal Syndrome - psychology
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