Remifentanil Versus Meperidine For Monitored Anesthesia Care: A Comparison Study in Older Patients Undergoing Ambulatory Colonoscopy
Colonoscopy is one of the most frequently performed outpatient procedures in the United States. This study was designed to test the hypothesis that a remifentanil infusion would be superior to boluses of meperidine in older patients undergoing ambulatory colonoscopy. One hundred ASA physical status...
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| Veröffentlicht in: | Anesthesia and analgesia 2001-01, Vol.92 (1), p.80-84 |
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| creator | Greilich, Philip E. Virella, Cesar D. Rich, James M. Kurada, Mangala Roberts, Kevin Warren, James F. Harford, William V. |
| description | Colonoscopy is one of the most frequently performed outpatient procedures in the United States. This study was designed to test the hypothesis that a remifentanil infusion would be superior to boluses of meperidine in older patients undergoing ambulatory colonoscopy. One hundred ASA physical status I-IV patients undergoing colonoscopy were randomized in this double-blinded study to receive either remifentanil infusions (n = 49) or titrated boluses of meperidine (n = 51). Patient tolerance was assessed using physiologic variables and side effects associated with opioid analgesia. Verbal pain/anxiety and patient/operator satisfaction were also assessed. As a group, the physiologic characteristics demonstrated no significant differences in the response to the colonoscopy procedure. Although the patient and operator satisfaction surveys were similar between groups, the incidences of tachycardia, hypotension, and nausea were less and the adjusted verbal pain and anxiety scores were more in the Remifentanil group compared with the Meperidine group. This study demonstrates that remifentanil and meperidine were equally well tolerated in older patients undergoing ambulatory colonoscopy when administered by an anesthesia provider. The differences in the pharmakinetics of remifentanil and meperidine most likely account for the differences noted between the two treatment groups.
Remifentanil infusions and meperidine boluses are equally well tolerated in older patients undergoing ambulatory colonoscopy when administered by an anesthesia provider. |
| doi_str_mv | 10.1097/00000539-200101000-00016 |
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Remifentanil infusions and meperidine boluses are equally well tolerated in older patients undergoing ambulatory colonoscopy when administered by an anesthesia provider.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1097/00000539-200101000-00016</identifier><identifier>PMID: 11133605</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: International Anesthesia Research Society</publisher><subject>Adjuvants, Anesthesia - administration & dosage ; Adjuvants, Anesthesia - adverse effects ; Aged ; Ambulatory Care ; Analgesics ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - adverse effects ; Anesthetics, Intravenous - administration & dosage ; Anesthetics, Intravenous - adverse effects ; Anxiety - drug therapy ; Anxiety - etiology ; Biological and medical sciences ; Colonoscopy - adverse effects ; Colonoscopy - methods ; Double-Blind Method ; Female ; Humans ; Infusions, Intravenous ; Injections, Intravenous ; Male ; Medical sciences ; Meperidine - administration & dosage ; Meperidine - adverse effects ; Middle Aged ; Neuropharmacology ; Pain - drug therapy ; Pain - etiology ; Pain Measurement - drug effects ; Pharmacology. Drug treatments ; Piperidines - administration & dosage ; Piperidines - adverse effects ; Remifentanil</subject><ispartof>Anesthesia and analgesia, 2001-01, Vol.92 (1), p.80-84</ispartof><rights>International Anesthesia Research Society</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4346-c27531c716d4229574f9fd2afee1303fc89b96853e576dd8f619201f957faad13</citedby><cites>FETCH-LOGICAL-c4346-c27531c716d4229574f9fd2afee1303fc89b96853e576dd8f619201f957faad13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00000539-200101000-00016$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,4036,4037,4595,23909,23910,25118,27901,27902,65206</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=843029$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11133605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greilich, Philip E.</creatorcontrib><creatorcontrib>Virella, Cesar D.</creatorcontrib><creatorcontrib>Rich, James M.</creatorcontrib><creatorcontrib>Kurada, Mangala</creatorcontrib><creatorcontrib>Roberts, Kevin</creatorcontrib><creatorcontrib>Warren, James F.</creatorcontrib><creatorcontrib>Harford, William V.</creatorcontrib><title>Remifentanil Versus Meperidine For Monitored Anesthesia Care: A Comparison Study in Older Patients Undergoing Ambulatory Colonoscopy</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>Colonoscopy is one of the most frequently performed outpatient procedures in the United States. This study was designed to test the hypothesis that a remifentanil infusion would be superior to boluses of meperidine in older patients undergoing ambulatory colonoscopy. One hundred ASA physical status I-IV patients undergoing colonoscopy were randomized in this double-blinded study to receive either remifentanil infusions (n = 49) or titrated boluses of meperidine (n = 51). Patient tolerance was assessed using physiologic variables and side effects associated with opioid analgesia. Verbal pain/anxiety and patient/operator satisfaction were also assessed. As a group, the physiologic characteristics demonstrated no significant differences in the response to the colonoscopy procedure. Although the patient and operator satisfaction surveys were similar between groups, the incidences of tachycardia, hypotension, and nausea were less and the adjusted verbal pain and anxiety scores were more in the Remifentanil group compared with the Meperidine group. This study demonstrates that remifentanil and meperidine were equally well tolerated in older patients undergoing ambulatory colonoscopy when administered by an anesthesia provider. The differences in the pharmakinetics of remifentanil and meperidine most likely account for the differences noted between the two treatment groups.
Remifentanil infusions and meperidine boluses are equally well tolerated in older patients undergoing ambulatory colonoscopy when administered by an anesthesia provider.</description><subject>Adjuvants, Anesthesia - administration & dosage</subject><subject>Adjuvants, Anesthesia - adverse effects</subject><subject>Aged</subject><subject>Ambulatory Care</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Anesthetics, Intravenous - administration & dosage</subject><subject>Anesthetics, Intravenous - adverse effects</subject><subject>Anxiety - drug therapy</subject><subject>Anxiety - etiology</subject><subject>Biological and medical sciences</subject><subject>Colonoscopy - adverse effects</subject><subject>Colonoscopy - methods</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meperidine - administration & dosage</subject><subject>Meperidine - adverse effects</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pain - drug therapy</subject><subject>Pain - etiology</subject><subject>Pain Measurement - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperidines - administration & dosage</subject><subject>Piperidines - adverse effects</subject><subject>Remifentanil</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v2yAYh9G0as2yfYUJaWev_LGx2S2Klq5Sq1Zts6tFzEtDi8ECW1Xu--AlS9aeCkKvQM_vd3hACFPygxJZn5H9qrgsGCE0b0KKfKj4gGa0YqKoK9l8RLP8xgsmpTxFn1N63COkEZ_QKaWUc0GqGfp7C7014EflrcN_IKYp4SsYIFptPeBViPgqeDuGCBovPKRxC8kqvFQRfuIFXoZ-UNGm4PHdOOkdth5fOw0R36jR5uKE1z5fH4L1D3jRbyanctkuB13wIXVh2H1BJ0a5BF-Pc47Wq1_3y9_F5fX5xXJxWXQlL0XRsbritKup0CVjsqpLI41mygBQTrjpGrmRoqk4VLXQujGCSkaoyaRRSlM-R82ht4shpQimHaLtVdy1lLR7se1_se2r2Paf2Bz9dogO06YH_RY8mszA9yOgUqecicp3Nr1yTckJk5kqD9RzcGOW_eSmZ4jtFpQbt-1738pfAPhwkQA</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Greilich, Philip E.</creator><creator>Virella, Cesar D.</creator><creator>Rich, James M.</creator><creator>Kurada, Mangala</creator><creator>Roberts, Kevin</creator><creator>Warren, James F.</creator><creator>Harford, William V.</creator><general>International Anesthesia Research Society</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010101</creationdate><title>Remifentanil Versus Meperidine For Monitored Anesthesia Care: A Comparison Study in Older Patients Undergoing Ambulatory Colonoscopy</title><author>Greilich, Philip E. ; Virella, Cesar D. ; Rich, James M. ; Kurada, Mangala ; Roberts, Kevin ; Warren, James F. ; Harford, William V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4346-c27531c716d4229574f9fd2afee1303fc89b96853e576dd8f619201f957faad13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adjuvants, Anesthesia - administration & dosage</topic><topic>Adjuvants, Anesthesia - adverse effects</topic><topic>Aged</topic><topic>Ambulatory Care</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Anesthetics, Intravenous - administration & dosage</topic><topic>Anesthetics, Intravenous - adverse effects</topic><topic>Anxiety - drug therapy</topic><topic>Anxiety - etiology</topic><topic>Biological and medical sciences</topic><topic>Colonoscopy - adverse effects</topic><topic>Colonoscopy - methods</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Meperidine - administration & dosage</topic><topic>Meperidine - adverse effects</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pain - drug therapy</topic><topic>Pain - etiology</topic><topic>Pain Measurement - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperidines - administration & dosage</topic><topic>Piperidines - adverse effects</topic><topic>Remifentanil</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greilich, Philip E.</creatorcontrib><creatorcontrib>Virella, Cesar D.</creatorcontrib><creatorcontrib>Rich, James M.</creatorcontrib><creatorcontrib>Kurada, Mangala</creatorcontrib><creatorcontrib>Roberts, Kevin</creatorcontrib><creatorcontrib>Warren, James F.</creatorcontrib><creatorcontrib>Harford, William V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greilich, Philip E.</au><au>Virella, Cesar D.</au><au>Rich, James M.</au><au>Kurada, Mangala</au><au>Roberts, Kevin</au><au>Warren, James F.</au><au>Harford, William V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Remifentanil Versus Meperidine For Monitored Anesthesia Care: A Comparison Study in Older Patients Undergoing Ambulatory Colonoscopy</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>92</volume><issue>1</issue><spage>80</spage><epage>84</epage><pages>80-84</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>Colonoscopy is one of the most frequently performed outpatient procedures in the United States. This study was designed to test the hypothesis that a remifentanil infusion would be superior to boluses of meperidine in older patients undergoing ambulatory colonoscopy. One hundred ASA physical status I-IV patients undergoing colonoscopy were randomized in this double-blinded study to receive either remifentanil infusions (n = 49) or titrated boluses of meperidine (n = 51). Patient tolerance was assessed using physiologic variables and side effects associated with opioid analgesia. Verbal pain/anxiety and patient/operator satisfaction were also assessed. As a group, the physiologic characteristics demonstrated no significant differences in the response to the colonoscopy procedure. Although the patient and operator satisfaction surveys were similar between groups, the incidences of tachycardia, hypotension, and nausea were less and the adjusted verbal pain and anxiety scores were more in the Remifentanil group compared with the Meperidine group. This study demonstrates that remifentanil and meperidine were equally well tolerated in older patients undergoing ambulatory colonoscopy when administered by an anesthesia provider. The differences in the pharmakinetics of remifentanil and meperidine most likely account for the differences noted between the two treatment groups.
Remifentanil infusions and meperidine boluses are equally well tolerated in older patients undergoing ambulatory colonoscopy when administered by an anesthesia provider.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>11133605</pmid><doi>10.1097/00000539-200101000-00016</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adjuvants, Anesthesia - administration & dosage Adjuvants, Anesthesia - adverse effects Aged Ambulatory Care Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - adverse effects Anxiety - drug therapy Anxiety - etiology Biological and medical sciences Colonoscopy - adverse effects Colonoscopy - methods Double-Blind Method Female Humans Infusions, Intravenous Injections, Intravenous Male Medical sciences Meperidine - administration & dosage Meperidine - adverse effects Middle Aged Neuropharmacology Pain - drug therapy Pain - etiology Pain Measurement - drug effects Pharmacology. Drug treatments Piperidines - administration & dosage Piperidines - adverse effects Remifentanil |
| title | Remifentanil Versus Meperidine For Monitored Anesthesia Care: A Comparison Study in Older Patients Undergoing Ambulatory Colonoscopy |
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