Hydralazine Does Not Stimulate Prostacyclin Biosynthesis in Hypertensive Patients

The hypothesis that vascular prostacyclin synthesis is stimulated by the oral administration of hydralazine and may account for part of its vascular effect was tested. Eight white patients with mild essential hypertension were studied in a randomized, double-blind design to assess the effects of ind...

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Veröffentlicht in:	The American journal of the medical sciences 1990-03, Vol.299 (3), p.170-174
Hauptverfasser:	Gerber, John G., Beckmann, M. Lee, Loverde, Mary, Byyny, Richard L., Nies, Alan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-dinor-6-keto-prostaglandin F1α Adult Aged Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Drug Interactions Epoprostenol - biosynthesis Female Humans Hydralazine Hydralazine - pharmacology Hypertension - metabolism Indomethacin Indomethacin - pharmacology Male Mass Spectrometry Medical sciences Middle Aged Pharmacology. Drug treatments Prostacyclin Biosynthesis
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