Immunologic Status of Patients in Remission from Hodgkin’s Disease and Disseminated Malignancies
The immunologic phenotypes of peripheral blood lymphocytes of 20 patients cured of Hodgkin’s disease (Group I) and of 20 patients cured of diverse, disseminated malignancies (Group II) were compared. Eleven patients in Group I had an increase in circulating B lymphocytes, and 6 patients in Group II...
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Veröffentlicht in: | The American journal of the medical sciences 1987-06, Vol.293 (6), p.366-370 |
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container_issue | 6 |
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container_title | The American journal of the medical sciences |
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creator | Shapiro, Charles M. Beckmann, Enrique Christiansen, Neal Bitran, Jacob D. Kozloff, Mark Billings, Arthur A. Telfer, Margaret C. |
description | The immunologic phenotypes of peripheral blood lymphocytes of 20 patients cured of Hodgkin’s disease (Group I) and of 20 patients cured of diverse, disseminated malignancies (Group II) were compared. Eleven patients in Group I had an increase in circulating B lymphocytes, and 6 patients in Group II had a decrease in this lymphocyte subset (0.0005 |
doi_str_mv | 10.1097/00000441-198706000-00004 |
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Eleven patients in Group I had an increase in circulating B lymphocytes, and 6 patients in Group II had a decrease in this lymphocyte subset (0.0005<p<0.0025). The T8 lymphocyte subset was increased in four patients in Group I and decreased in five patients in Group II (0.005<p<0.0125). The T4/T8 lymphocyte ratio was less than 1.0 in eight patients in Group I and in no patients in Group II (p<0.001). These statistically significant differences between the two groups were unrelated to type or duration of therapy, and thus suggest basic biologic differences between the immune status of cured Hodgkin’s disease patients and cured patients with other malignancies.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/00000441-198706000-00004</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cancer ; Hodgkin’s Disease ; Host-tumor relations. Immunology. 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Eleven patients in Group I had an increase in circulating B lymphocytes, and 6 patients in Group II had a decrease in this lymphocyte subset (0.0005<p<0.0025). The T8 lymphocyte subset was increased in four patients in Group I and decreased in five patients in Group II (0.005<p<0.0125). The T4/T8 lymphocyte ratio was less than 1.0 in eight patients in Group I and in no patients in Group II (p<0.001). These statistically significant differences between the two groups were unrelated to type or duration of therapy, and thus suggest basic biologic differences between the immune status of cured Hodgkin’s disease patients and cured patients with other malignancies.</description><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Hodgkin’s Disease</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Immunologic Phenotypes</subject><subject>Medical sciences</subject><subject>T4/T8 Lymphocyte Ratio</subject><subject>Tumors</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNqFUEtOwzAUtBBIlMIdvGAbsJ00tpdQPq1UBILuI8efypDYVV6KxI5rcD1OgtNCt7zNPI9mbM8ghCm5oETySzJMUdCMSsFJmQ7ZljlAIzrJRcakJIdolCiWyZLJY3QC8EoIZYLmI1TP23YTYhNXXuOXXvUbwNHhJ9V7G3rAPuBn23oAHwN2XWzxLJrVmw_fn1-AbzxYBRarYIYdkjKo3hr8oBq_Cipob-EUHTnVgD37xTFa3t0up7Ns8Xg_n14tMs1K0mfCllQ47oyuiZDW0pwrztVEcicKlVA7S0vJpDJOM8fZpBY0haulETlx-RiJ3bW6iwCdddW6863qPipKqqGq6q-qal_VliqS9XxnXSvQqnHd8HHY-wUTBadlkl3vZDalePe2qyDlC9oa31ndVyb6_9_6AawBf3E</recordid><startdate>198706</startdate><enddate>198706</enddate><creator>Shapiro, Charles M.</creator><creator>Beckmann, Enrique</creator><creator>Christiansen, Neal</creator><creator>Bitran, Jacob D.</creator><creator>Kozloff, Mark</creator><creator>Billings, Arthur A.</creator><creator>Telfer, Margaret C.</creator><general>Elsevier Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198706</creationdate><title>Immunologic Status of Patients in Remission from Hodgkin’s Disease and Disseminated Malignancies</title><author>Shapiro, Charles M. ; Beckmann, Enrique ; Christiansen, Neal ; Bitran, Jacob D. ; Kozloff, Mark ; Billings, Arthur A. ; Telfer, Margaret C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c260t-8e618f7fdcb089ee137a77a597f84aa59cfe16929adfc2f725b81990b9d830f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Hodgkin’s Disease</topic><topic>Host-tumor relations. Immunology. Biological markers</topic><topic>Immunologic Phenotypes</topic><topic>Medical sciences</topic><topic>T4/T8 Lymphocyte Ratio</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shapiro, Charles M.</creatorcontrib><creatorcontrib>Beckmann, Enrique</creatorcontrib><creatorcontrib>Christiansen, Neal</creatorcontrib><creatorcontrib>Bitran, Jacob D.</creatorcontrib><creatorcontrib>Kozloff, Mark</creatorcontrib><creatorcontrib>Billings, Arthur A.</creatorcontrib><creatorcontrib>Telfer, Margaret C.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shapiro, Charles M.</au><au>Beckmann, Enrique</au><au>Christiansen, Neal</au><au>Bitran, Jacob D.</au><au>Kozloff, Mark</au><au>Billings, Arthur A.</au><au>Telfer, Margaret C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunologic Status of Patients in Remission from Hodgkin’s Disease and Disseminated Malignancies</atitle><jtitle>The American journal of the medical sciences</jtitle><date>1987-06</date><risdate>1987</risdate><volume>293</volume><issue>6</issue><spage>366</spage><epage>370</epage><pages>366-370</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><coden>AJMSA9</coden><abstract>The immunologic phenotypes of peripheral blood lymphocytes of 20 patients cured of Hodgkin’s disease (Group I) and of 20 patients cured of diverse, disseminated malignancies (Group II) were compared. Eleven patients in Group I had an increase in circulating B lymphocytes, and 6 patients in Group II had a decrease in this lymphocyte subset (0.0005<p<0.0025). The T8 lymphocyte subset was increased in four patients in Group I and decreased in five patients in Group II (0.005<p<0.0125). The T4/T8 lymphocyte ratio was less than 1.0 in eight patients in Group I and in no patients in Group II (p<0.001). These statistically significant differences between the two groups were unrelated to type or duration of therapy, and thus suggest basic biologic differences between the immune status of cured Hodgkin’s disease patients and cured patients with other malignancies.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><doi>10.1097/00000441-198706000-00004</doi><tpages>5</tpages></addata></record> |
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source | Journals@Ovid Complete; Alma/SFX Local Collection |
subjects | Biological and medical sciences Cancer Hodgkin’s Disease Host-tumor relations. Immunology. Biological markers Immunologic Phenotypes Medical sciences T4/T8 Lymphocyte Ratio Tumors |
title | Immunologic Status of Patients in Remission from Hodgkin’s Disease and Disseminated Malignancies |
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