Prolactin and Blood Pressure Responses to Perphenazine in Human Subjects: Comparison of the Oral and Intramuscular Routes
Although several phenothiazines are known to stimulate prolactin (PRL) secretion, only chlorpromazine is in general use for this purpose in humans. However, chlorpromazine has severe sedative and hypotensive effects. Therefore, the effects of perphenazine on human PRL release and on blood pressure w...
Gespeichert in:
| Veröffentlicht in: | The American journal of the medical sciences 1986-06, Vol.291 (6), p.380-385 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 385 |
|---|---|
| container_issue | 6 |
| container_start_page | 380 |
| container_title | The American journal of the medical sciences |
| container_volume | 291 |
| creator | Musey, Victoria C. Preedy, John R.K. Musey, Paul I. Blank, Michael S. Brogan, Donna R. Bain, Raymond P. Collins, Delwood C. |
| description | Although several phenothiazines are known to stimulate prolactin (PRL) secretion, only chlorpromazine is in general use for this purpose in humans. However, chlorpromazine has severe sedative and hypotensive effects. Therefore, the effects of perphenazine on human PRL release and on blood pressure were evaluated. Perphenazine was administered orally (8mg) and intramuscularly (5mg and 2mg) to determine the optimal route and dose for evaluating PRL release. The postural hypotensive effect of perphenazine was evaluated with the 2mg intramuscular (IM) dose. The mean time of peak PRL response (hr±SD) was significantly shorter (p |
| doi_str_mv | 10.1097/00000441-198606000-00002 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00000441_198606000_00002</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002962915369500</els_id><sourcerecordid>3717195</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-362c6831dba9b11cae5b25334fbe78b0201e40a37071044da826bfe3d0ff1a5a3</originalsourceid><addsrcrecordid>eNqFkE9P3DAQxa2KCra0H6GSD72G-s8msbmVVQtISKxoe44mzkQYJXbkSZDop6-XXfaKL5bfvPc0_jHGpbiQwtbfxe6s17KQ1lSiyo9ip6gPbCVLbQplrThhq51U2ErZM_aJ6EkIqYzUp-xU17KWtlyxl22KA7jZBw6h41dDjB3fJiRaEvIHpCkGQuJz5FtM0yMG-OcD8uy_WUYI_PfSPqGb6ZJv4jhB8hQDjz2fH5HfJxhea2_DnGBcyC0DJP4QlxnpM_vYw0D45XCfs7-_fv7Z3BR399e3mx93hdPWzIWulKuMll0LtpXSAZatKrVe9y3WphVKSFwL0LWoZSbSgVFV26PuRN9LKEGfM7PvdSkSJeybKfkR0ksjRbOD2bzBbI4wXyWVo1_30WlpR-yOwQO9PP92mAM5GPoEwXk62kxtbG7Jtqu9DfM3nz2mhpzH4LDzKaNruujf3-U_vmaR1w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Prolactin and Blood Pressure Responses to Perphenazine in Human Subjects: Comparison of the Oral and Intramuscular Routes</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Alma/SFX Local Collection</source><creator>Musey, Victoria C. ; Preedy, John R.K. ; Musey, Paul I. ; Blank, Michael S. ; Brogan, Donna R. ; Bain, Raymond P. ; Collins, Delwood C.</creator><creatorcontrib>Musey, Victoria C. ; Preedy, John R.K. ; Musey, Paul I. ; Blank, Michael S. ; Brogan, Donna R. ; Bain, Raymond P. ; Collins, Delwood C.</creatorcontrib><description>Although several phenothiazines are known to stimulate prolactin (PRL) secretion, only chlorpromazine is in general use for this purpose in humans. However, chlorpromazine has severe sedative and hypotensive effects. Therefore, the effects of perphenazine on human PRL release and on blood pressure were evaluated. Perphenazine was administered orally (8mg) and intramuscularly (5mg and 2mg) to determine the optimal route and dose for evaluating PRL release. The postural hypotensive effect of perphenazine was evaluated with the 2mg intramuscular (IM) dose. The mean time of peak PRL response (hr±SD) was significantly shorter (p<0.05) for the 5mg IM (1.7±0.4) than the oral (4.5±0.6) route. Also, the mean ratio of peak/baseline PRL was significantly greater for the 5mg IM (8.87±5.69) than the oral (5.12±2.90) route. The major side-effect produced by perphenazine was drowsiness, which was moderate to severe with the 5mg IM dose. A lower IM dose (2mg) retained PRL releasing activity, reduced drowsiness, and did not produce hypotension. For clinical testing, intramuscular perphenazine is preferred over oral perphenazine because of the shorter latency period and the higher PRL levels. Intramuscular perphenazine (2mg) is preferred to chlorpromazine since it did not produce a clinically significant hypotensive effect. This is the first report on the dynamic responses of PRL and blood pressure to intramuscular perphenazine in humans.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/00000441-198606000-00002</identifier><identifier>PMID: 3717195</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Administration, Oral ; Adolescent ; Adult ; Biological and medical sciences ; Blood Pressure ; Blood Pressure - drug effects ; Female ; Humans ; Injections, Intramuscular ; Intramuscular ; Male ; Medical sciences ; Neuropharmacology ; Oral ; Perphenazine ; Perphenazine - administration & dosage ; Perphenazine - adverse effects ; Perphenazine - pharmacology ; Pharmacology. Drug treatments ; Phenothiazines ; Prolactin ; Prolactin - blood ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Pulse Rate</subject><ispartof>The American journal of the medical sciences, 1986-06, Vol.291 (6), p.380-385</ispartof><rights>1986 Southern Society for Clinical Investigation</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-362c6831dba9b11cae5b25334fbe78b0201e40a37071044da826bfe3d0ff1a5a3</citedby><cites>FETCH-LOGICAL-c398t-362c6831dba9b11cae5b25334fbe78b0201e40a37071044da826bfe3d0ff1a5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8789023$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3717195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Musey, Victoria C.</creatorcontrib><creatorcontrib>Preedy, John R.K.</creatorcontrib><creatorcontrib>Musey, Paul I.</creatorcontrib><creatorcontrib>Blank, Michael S.</creatorcontrib><creatorcontrib>Brogan, Donna R.</creatorcontrib><creatorcontrib>Bain, Raymond P.</creatorcontrib><creatorcontrib>Collins, Delwood C.</creatorcontrib><title>Prolactin and Blood Pressure Responses to Perphenazine in Human Subjects: Comparison of the Oral and Intramuscular Routes</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Although several phenothiazines are known to stimulate prolactin (PRL) secretion, only chlorpromazine is in general use for this purpose in humans. However, chlorpromazine has severe sedative and hypotensive effects. Therefore, the effects of perphenazine on human PRL release and on blood pressure were evaluated. Perphenazine was administered orally (8mg) and intramuscularly (5mg and 2mg) to determine the optimal route and dose for evaluating PRL release. The postural hypotensive effect of perphenazine was evaluated with the 2mg intramuscular (IM) dose. The mean time of peak PRL response (hr±SD) was significantly shorter (p<0.05) for the 5mg IM (1.7±0.4) than the oral (4.5±0.6) route. Also, the mean ratio of peak/baseline PRL was significantly greater for the 5mg IM (8.87±5.69) than the oral (5.12±2.90) route. The major side-effect produced by perphenazine was drowsiness, which was moderate to severe with the 5mg IM dose. A lower IM dose (2mg) retained PRL releasing activity, reduced drowsiness, and did not produce hypotension. For clinical testing, intramuscular perphenazine is preferred over oral perphenazine because of the shorter latency period and the higher PRL levels. Intramuscular perphenazine (2mg) is preferred to chlorpromazine since it did not produce a clinically significant hypotensive effect. This is the first report on the dynamic responses of PRL and blood pressure to intramuscular perphenazine in humans.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Intramuscular</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Oral</subject><subject>Perphenazine</subject><subject>Perphenazine - administration & dosage</subject><subject>Perphenazine - adverse effects</subject><subject>Perphenazine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenothiazines</subject><subject>Prolactin</subject><subject>Prolactin - blood</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Pulse Rate</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9P3DAQxa2KCra0H6GSD72G-s8msbmVVQtISKxoe44mzkQYJXbkSZDop6-XXfaKL5bfvPc0_jHGpbiQwtbfxe6s17KQ1lSiyo9ip6gPbCVLbQplrThhq51U2ErZM_aJ6EkIqYzUp-xU17KWtlyxl22KA7jZBw6h41dDjB3fJiRaEvIHpCkGQuJz5FtM0yMG-OcD8uy_WUYI_PfSPqGb6ZJv4jhB8hQDjz2fH5HfJxhea2_DnGBcyC0DJP4QlxnpM_vYw0D45XCfs7-_fv7Z3BR399e3mx93hdPWzIWulKuMll0LtpXSAZatKrVe9y3WphVKSFwL0LWoZSbSgVFV26PuRN9LKEGfM7PvdSkSJeybKfkR0ksjRbOD2bzBbI4wXyWVo1_30WlpR-yOwQO9PP92mAM5GPoEwXk62kxtbG7Jtqu9DfM3nz2mhpzH4LDzKaNruujf3-U_vmaR1w</recordid><startdate>19860601</startdate><enddate>19860601</enddate><creator>Musey, Victoria C.</creator><creator>Preedy, John R.K.</creator><creator>Musey, Paul I.</creator><creator>Blank, Michael S.</creator><creator>Brogan, Donna R.</creator><creator>Bain, Raymond P.</creator><creator>Collins, Delwood C.</creator><general>Elsevier Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19860601</creationdate><title>Prolactin and Blood Pressure Responses to Perphenazine in Human Subjects: Comparison of the Oral and Intramuscular Routes</title><author>Musey, Victoria C. ; Preedy, John R.K. ; Musey, Paul I. ; Blank, Michael S. ; Brogan, Donna R. ; Bain, Raymond P. ; Collins, Delwood C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-362c6831dba9b11cae5b25334fbe78b0201e40a37071044da826bfe3d0ff1a5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Intramuscular</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Oral</topic><topic>Perphenazine</topic><topic>Perphenazine - administration & dosage</topic><topic>Perphenazine - adverse effects</topic><topic>Perphenazine - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenothiazines</topic><topic>Prolactin</topic><topic>Prolactin - blood</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Pulse Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Musey, Victoria C.</creatorcontrib><creatorcontrib>Preedy, John R.K.</creatorcontrib><creatorcontrib>Musey, Paul I.</creatorcontrib><creatorcontrib>Blank, Michael S.</creatorcontrib><creatorcontrib>Brogan, Donna R.</creatorcontrib><creatorcontrib>Bain, Raymond P.</creatorcontrib><creatorcontrib>Collins, Delwood C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Musey, Victoria C.</au><au>Preedy, John R.K.</au><au>Musey, Paul I.</au><au>Blank, Michael S.</au><au>Brogan, Donna R.</au><au>Bain, Raymond P.</au><au>Collins, Delwood C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolactin and Blood Pressure Responses to Perphenazine in Human Subjects: Comparison of the Oral and Intramuscular Routes</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>1986-06-01</date><risdate>1986</risdate><volume>291</volume><issue>6</issue><spage>380</spage><epage>385</epage><pages>380-385</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><coden>AJMSA9</coden><abstract>Although several phenothiazines are known to stimulate prolactin (PRL) secretion, only chlorpromazine is in general use for this purpose in humans. However, chlorpromazine has severe sedative and hypotensive effects. Therefore, the effects of perphenazine on human PRL release and on blood pressure were evaluated. Perphenazine was administered orally (8mg) and intramuscularly (5mg and 2mg) to determine the optimal route and dose for evaluating PRL release. The postural hypotensive effect of perphenazine was evaluated with the 2mg intramuscular (IM) dose. The mean time of peak PRL response (hr±SD) was significantly shorter (p<0.05) for the 5mg IM (1.7±0.4) than the oral (4.5±0.6) route. Also, the mean ratio of peak/baseline PRL was significantly greater for the 5mg IM (8.87±5.69) than the oral (5.12±2.90) route. The major side-effect produced by perphenazine was drowsiness, which was moderate to severe with the 5mg IM dose. A lower IM dose (2mg) retained PRL releasing activity, reduced drowsiness, and did not produce hypotension. For clinical testing, intramuscular perphenazine is preferred over oral perphenazine because of the shorter latency period and the higher PRL levels. Intramuscular perphenazine (2mg) is preferred to chlorpromazine since it did not produce a clinically significant hypotensive effect. This is the first report on the dynamic responses of PRL and blood pressure to intramuscular perphenazine in humans.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>3717195</pmid><doi>10.1097/00000441-198606000-00002</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9629 |
| ispartof | The American journal of the medical sciences, 1986-06, Vol.291 (6), p.380-385 |
| issn | 0002-9629 1538-2990 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00000441_198606000_00002 |
| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Administration, Oral Adolescent Adult Biological and medical sciences Blood Pressure Blood Pressure - drug effects Female Humans Injections, Intramuscular Intramuscular Male Medical sciences Neuropharmacology Oral Perphenazine Perphenazine - administration & dosage Perphenazine - adverse effects Perphenazine - pharmacology Pharmacology. Drug treatments Phenothiazines Prolactin Prolactin - blood Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pulse Rate |
| title | Prolactin and Blood Pressure Responses to Perphenazine in Human Subjects: Comparison of the Oral and Intramuscular Routes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T18%3A33%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prolactin%20and%20Blood%20Pressure%20Responses%20to%20Perphenazine%20in%20Human%20Subjects:%20Comparison%20of%20the%20Oral%20and%20Intramuscular%20Routes&rft.jtitle=The%20American%20journal%20of%20the%20medical%20sciences&rft.au=Musey,%20Victoria%20C.&rft.date=1986-06-01&rft.volume=291&rft.issue=6&rft.spage=380&rft.epage=385&rft.pages=380-385&rft.issn=0002-9629&rft.eissn=1538-2990&rft.coden=AJMSA9&rft_id=info:doi/10.1097/00000441-198606000-00002&rft_dat=%3Cpubmed_cross%3E3717195%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/3717195&rft_els_id=S0002962915369500&rfr_iscdi=true |