The Alpha2-Adrenergic System of the Platelet in Cystic Fibrosis
The ability of norepinephrine to inhibit prostaglandin E1 (PGE1)-stimulated accumulation of adenosine 3′:5′ cyclic monophosphate (cyclic AMP) in intact washed platelets was determined in 12 patients with cystic fibrosis, 6 parents of patients with cystic fibrosis, and a total of 21 healthy age-match...
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| Veröffentlicht in: | The American journal of the medical sciences 1984-10, Vol.288 (3), p.104-108 |
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| container_end_page | 108 |
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| container_issue | 3 |
| container_start_page | 104 |
| container_title | The American journal of the medical sciences |
| container_volume | 288 |
| creator | Davis, Pamela B. Dieckman, Lynda Boat, Thomas F. Stern, Robert C. Doershuk, Carl F. |
| description | The ability of norepinephrine to inhibit prostaglandin E1 (PGE1)-stimulated accumulation of adenosine 3′:5′ cyclic monophosphate (cyclic AMP) in intact washed platelets was determined in 12 patients with cystic fibrosis, 6 parents of patients with cystic fibrosis, and a total of 21 healthy age-matched controls. Patients with cystic fibrosis and their parents did not differ from their age-matched controls in basal or PGE1-stimulated levels of cyclic AMP, nor in the dose dependent inhibition of cAMP accumulation by norepinephrine. Moreover, binding sites for [3H]-dihydroergocryptine were present in normal numbers and had normal ligand affinity in platelet membranes from patients with cystic fibrosis. In all measures tested, the alpha2-adrenergic system in the platelet was normal in cystic fibrosis. |
| doi_str_mv | 10.1097/00000441-198410000-00002 |
| format | Article |
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Patients with cystic fibrosis and their parents did not differ from their age-matched controls in basal or PGE1-stimulated levels of cyclic AMP, nor in the dose dependent inhibition of cAMP accumulation by norepinephrine. Moreover, binding sites for [3H]-dihydroergocryptine were present in normal numbers and had normal ligand affinity in platelet membranes from patients with cystic fibrosis. In all measures tested, the alpha2-adrenergic system in the platelet was normal in cystic fibrosis.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/00000441-198410000-00002</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Alpha-adrenergic receptor ; Biological and medical sciences ; Cystic fibrosis ; Gastroenterology. Liver. Pancreas. Abdomen ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Other diseases. 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Patients with cystic fibrosis and their parents did not differ from their age-matched controls in basal or PGE1-stimulated levels of cyclic AMP, nor in the dose dependent inhibition of cAMP accumulation by norepinephrine. Moreover, binding sites for [3H]-dihydroergocryptine were present in normal numbers and had normal ligand affinity in platelet membranes from patients with cystic fibrosis. In all measures tested, the alpha2-adrenergic system in the platelet was normal in cystic fibrosis.</description><subject>Alpha-adrenergic receptor</subject><subject>Biological and medical sciences</subject><subject>Cystic fibrosis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Other diseases. 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Liver. Pancreas. Abdomen</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Other diseases. 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Patients with cystic fibrosis and their parents did not differ from their age-matched controls in basal or PGE1-stimulated levels of cyclic AMP, nor in the dose dependent inhibition of cAMP accumulation by norepinephrine. Moreover, binding sites for [3H]-dihydroergocryptine were present in normal numbers and had normal ligand affinity in platelet membranes from patients with cystic fibrosis. In all measures tested, the alpha2-adrenergic system in the platelet was normal in cystic fibrosis.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><doi>10.1097/00000441-198410000-00002</doi><tpages>5</tpages></addata></record> |
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| ispartof | The American journal of the medical sciences, 1984-10, Vol.288 (3), p.104-108 |
| issn | 0002-9629 1538-2990 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00000441_198410000_00002 |
| source | Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Alpha-adrenergic receptor Biological and medical sciences Cystic fibrosis Gastroenterology. Liver. Pancreas. Abdomen Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology Platelets |
| title | The Alpha2-Adrenergic System of the Platelet in Cystic Fibrosis |
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