Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis

This study was aimed at assessing the efficacy of allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. A randomized double-blind, placebo-controlled trial was thus designed to test its efficacy to treat oral mucositis in advanced cancer patients receiving 5-fluorouracil-con...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of clinical oncology 1994-06, Vol.17 (3), p.246-247
Hauptverfasser: PORTA, C, MORONI, M, NASTASI, G
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 247
container_issue 3
container_start_page 246
container_title American journal of clinical oncology
container_volume 17
creator PORTA, C
MORONI, M
NASTASI, G
description This study was aimed at assessing the efficacy of allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. A randomized double-blind, placebo-controlled trial was thus designed to test its efficacy to treat oral mucositis in advanced cancer patients receiving 5-fluorouracil-containing chemotherapy. There were 44 patients randomized to receive allopurinol mouthwashes, or placebo, as soon as mucosal lesions were observed during any treatment cycle. Stomatitis was evaluated at the end of each 5-day treatment cycle. Allopurinol mouthwashes resolved stomatitis in 9 of 22 treated patients (40.9%), and diminished its intensity in 10 more patients (45.4%); stomatitis resolved completely in none of the 22 patients, and partially in 3 patients in the placebo group (p < .001 by chi 2 test). Duration of symptoms was also significantly different between the two groups (median: 4 days for the allopurinol group, 7.5 days for the control group; p < .0005 by Student's t-test). In conclusion, our results suggest that allopurinol mouthwashes can be effective to treat 5-fluorouracil-induced stomatitis.
doi_str_mv 10.1097/00000421-199406000-00014
format Article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00000421_199406000_00014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>8192112</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-b76b8bae226790949056d55b6942be3f27f40c7149b604b4a0bf64985bcd4a7d3</originalsourceid><addsrcrecordid>eNo9kE9LAzEQxYMotVY_gpCD12iSnWyaYyn-g4oXBW9Lkk1oZHdTkizit3e1tQPDMLz3huGHEGb0llEl7-hvAWeEKQW0nhYyNYMTNGeikgRE9XGK5pRLSSpZ8XN0kfPnZBE1lTM0WzLFGeNz9LLqurgbUxhih_s4lu2XzluXcRhw2TpcktOld0PB0WNBfDfGFMekbehIGNrRuhbnEntdQgn5Ep153WV3dZgL9P5w_7Z-IpvXx-f1akMsUFGIkbVZGu04r6WiCtT0ViuEqRVw4yrPpQdqJQNlagoGNDW-BrUUxragZVst0HJ_16aYc3K-2aXQ6_TdMNr8Amr-ATVHQM0foCl6vY_uRtO79hg8EJn0m4Ous9WdT3qwIR9twIQQQKsf_tluEA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>PORTA, C ; MORONI, M ; NASTASI, G</creator><creatorcontrib>PORTA, C ; MORONI, M ; NASTASI, G</creatorcontrib><description>This study was aimed at assessing the efficacy of allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. A randomized double-blind, placebo-controlled trial was thus designed to test its efficacy to treat oral mucositis in advanced cancer patients receiving 5-fluorouracil-containing chemotherapy. There were 44 patients randomized to receive allopurinol mouthwashes, or placebo, as soon as mucosal lesions were observed during any treatment cycle. Stomatitis was evaluated at the end of each 5-day treatment cycle. Allopurinol mouthwashes resolved stomatitis in 9 of 22 treated patients (40.9%), and diminished its intensity in 10 more patients (45.4%); stomatitis resolved completely in none of the 22 patients, and partially in 3 patients in the placebo group (p &lt; .001 by chi 2 test). Duration of symptoms was also significantly different between the two groups (median: 4 days for the allopurinol group, 7.5 days for the control group; p &lt; .0005 by Student's t-test). In conclusion, our results suggest that allopurinol mouthwashes can be effective to treat 5-fluorouracil-induced stomatitis.</description><identifier>ISSN: 0277-3732</identifier><identifier>EISSN: 1537-453X</identifier><identifier>DOI: 10.1097/00000421-199406000-00014</identifier><identifier>PMID: 8192112</identifier><identifier>CODEN: AJCODI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams &amp; Wilkins</publisher><subject>Adult ; Aged ; Allopurinol - therapeutic use ; Biological and medical sciences ; Double-Blind Method ; Drug toxicity and drugs side effects treatment ; Fluorouracil - adverse effects ; Humans ; Medical sciences ; Middle Aged ; Mouthwashes - chemistry ; Mouthwashes - therapeutic use ; Pharmacology. Drug treatments ; Stomatitis - drug therapy ; Stomatitis - etiology ; Toxicity: respiratory system, ent, stomatology</subject><ispartof>American journal of clinical oncology, 1994-06, Vol.17 (3), p.246-247</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-b76b8bae226790949056d55b6942be3f27f40c7149b604b4a0bf64985bcd4a7d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=4155540$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8192112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PORTA, C</creatorcontrib><creatorcontrib>MORONI, M</creatorcontrib><creatorcontrib>NASTASI, G</creatorcontrib><title>Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis</title><title>American journal of clinical oncology</title><addtitle>Am J Clin Oncol</addtitle><description>This study was aimed at assessing the efficacy of allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. A randomized double-blind, placebo-controlled trial was thus designed to test its efficacy to treat oral mucositis in advanced cancer patients receiving 5-fluorouracil-containing chemotherapy. There were 44 patients randomized to receive allopurinol mouthwashes, or placebo, as soon as mucosal lesions were observed during any treatment cycle. Stomatitis was evaluated at the end of each 5-day treatment cycle. Allopurinol mouthwashes resolved stomatitis in 9 of 22 treated patients (40.9%), and diminished its intensity in 10 more patients (45.4%); stomatitis resolved completely in none of the 22 patients, and partially in 3 patients in the placebo group (p &lt; .001 by chi 2 test). Duration of symptoms was also significantly different between the two groups (median: 4 days for the allopurinol group, 7.5 days for the control group; p &lt; .0005 by Student's t-test). In conclusion, our results suggest that allopurinol mouthwashes can be effective to treat 5-fluorouracil-induced stomatitis.</description><subject>Adult</subject><subject>Aged</subject><subject>Allopurinol - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Fluorouracil - adverse effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouthwashes - chemistry</subject><subject>Mouthwashes - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Stomatitis - drug therapy</subject><subject>Stomatitis - etiology</subject><subject>Toxicity: respiratory system, ent, stomatology</subject><issn>0277-3732</issn><issn>1537-453X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9LAzEQxYMotVY_gpCD12iSnWyaYyn-g4oXBW9Lkk1oZHdTkizit3e1tQPDMLz3huGHEGb0llEl7-hvAWeEKQW0nhYyNYMTNGeikgRE9XGK5pRLSSpZ8XN0kfPnZBE1lTM0WzLFGeNz9LLqurgbUxhih_s4lu2XzluXcRhw2TpcktOld0PB0WNBfDfGFMekbehIGNrRuhbnEntdQgn5Ep153WV3dZgL9P5w_7Z-IpvXx-f1akMsUFGIkbVZGu04r6WiCtT0ViuEqRVw4yrPpQdqJQNlagoGNDW-BrUUxragZVst0HJ_16aYc3K-2aXQ6_TdMNr8Amr-ATVHQM0foCl6vY_uRtO79hg8EJn0m4Ous9WdT3qwIR9twIQQQKsf_tluEA</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>PORTA, C</creator><creator>MORONI, M</creator><creator>NASTASI, G</creator><general>Lippincott Williams &amp; Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19940601</creationdate><title>Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis</title><author>PORTA, C ; MORONI, M ; NASTASI, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-b76b8bae226790949056d55b6942be3f27f40c7149b604b4a0bf64985bcd4a7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allopurinol - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Fluorouracil - adverse effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouthwashes - chemistry</topic><topic>Mouthwashes - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Stomatitis - drug therapy</topic><topic>Stomatitis - etiology</topic><topic>Toxicity: respiratory system, ent, stomatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PORTA, C</creatorcontrib><creatorcontrib>MORONI, M</creatorcontrib><creatorcontrib>NASTASI, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>American journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PORTA, C</au><au>MORONI, M</au><au>NASTASI, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis</atitle><jtitle>American journal of clinical oncology</jtitle><addtitle>Am J Clin Oncol</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>17</volume><issue>3</issue><spage>246</spage><epage>247</epage><pages>246-247</pages><issn>0277-3732</issn><eissn>1537-453X</eissn><coden>AJCODI</coden><abstract>This study was aimed at assessing the efficacy of allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis. A randomized double-blind, placebo-controlled trial was thus designed to test its efficacy to treat oral mucositis in advanced cancer patients receiving 5-fluorouracil-containing chemotherapy. There were 44 patients randomized to receive allopurinol mouthwashes, or placebo, as soon as mucosal lesions were observed during any treatment cycle. Stomatitis was evaluated at the end of each 5-day treatment cycle. Allopurinol mouthwashes resolved stomatitis in 9 of 22 treated patients (40.9%), and diminished its intensity in 10 more patients (45.4%); stomatitis resolved completely in none of the 22 patients, and partially in 3 patients in the placebo group (p &lt; .001 by chi 2 test). Duration of symptoms was also significantly different between the two groups (median: 4 days for the allopurinol group, 7.5 days for the control group; p &lt; .0005 by Student's t-test). In conclusion, our results suggest that allopurinol mouthwashes can be effective to treat 5-fluorouracil-induced stomatitis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams &amp; Wilkins</pub><pmid>8192112</pmid><doi>10.1097/00000421-199406000-00014</doi><tpages>2</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0277-3732
ispartof American journal of clinical oncology, 1994-06, Vol.17 (3), p.246-247
issn 0277-3732
1537-453X
language eng
recordid cdi_crossref_primary_10_1097_00000421_199406000_00014
source MEDLINE; Journals@Ovid Complete
subjects Adult
Aged
Allopurinol - therapeutic use
Biological and medical sciences
Double-Blind Method
Drug toxicity and drugs side effects treatment
Fluorouracil - adverse effects
Humans
Medical sciences
Middle Aged
Mouthwashes - chemistry
Mouthwashes - therapeutic use
Pharmacology. Drug treatments
Stomatitis - drug therapy
Stomatitis - etiology
Toxicity: respiratory system, ent, stomatology
title Allopurinol mouthwashes in the treatment of 5-fluorouracil-induced stomatitis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T13%3A02%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Allopurinol%20mouthwashes%20in%20the%20treatment%20of%205-fluorouracil-induced%20stomatitis&rft.jtitle=American%20journal%20of%20clinical%20oncology&rft.au=PORTA,%20C&rft.date=1994-06-01&rft.volume=17&rft.issue=3&rft.spage=246&rft.epage=247&rft.pages=246-247&rft.issn=0277-3732&rft.eissn=1537-453X&rft.coden=AJCODI&rft_id=info:doi/10.1097/00000421-199406000-00014&rft_dat=%3Cpubmed_cross%3E8192112%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/8192112&rfr_iscdi=true