Phase II trial of 10-Edam in patients with advanced colorectal carcinoma

10-Edam (10-ethyl-10-deaza-aminopterin), an antifolate derivative, was administered to 14 chemotherapy-naive patients with advanced colorectal carcinoma. The drug was given weekly by intravenous route at an initial dose of 80 mg/m2, with escalation or attenuation according to tolerance. Mucositis wa...

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Veröffentlicht in:	American journal of clinical oncology 1990-02, Vol.13 (1), p.42-44
Hauptverfasser:	KEMENY, N, ISRAEL, K, O'HEHIR, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Pain - chemically induced Adult Aged Aminopterin - administration & dosage Aminopterin - analogs & derivatives Aminopterin - therapeutic use Aminopterin - toxicity Antineoplastic agents Biological and medical sciences Carcinoma - drug therapy Chemotherapy Colonic Neoplasms - drug therapy Drug Evaluation Female Folic Acid Antagonists - administration & dosage Folic Acid Antagonists - therapeutic use Folic Acid Antagonists - toxicity Humans Injections, Intravenous Male Medical sciences Middle Aged Pharmacology. Drug treatments Rectal Neoplasms - drug therapy Remission Induction
Online-Zugang:	Volltext
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