Phase I study of thymidine (dThd) and cisplatin (DDP) given in combination

Twenty-three patients with a variety of solid tumors were given thymidine (dThd) at a single dose of 30 g/m2 along with cisplatin (DDP) at escalating doses ranging from 25 to 120 mg/m2. The dThd was administered first, and then after 50% of the total dThd dose had been infused over 1 h, the remainin...

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Veröffentlicht in:	American journal of clinical oncology 1986-04, Vol.9 (2), p.129-131
Hauptverfasser:	CHIUTEN, D. F, VALDIVIESO, M, BENVENUTO, J. A, DREWINKO, B, BEDIKIAN, A, BODEY, G. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Cisplatin - administration & dosage Cisplatin - adverse effects Cisplatin - toxicity Drug Evaluation Female Humans Male Medical sciences Middle Aged Nausea - chemically induced Pharmacology. Drug treatments Thrombocytopenia - chemically induced Thymidine - administration & dosage Thymidine - adverse effects Thymidine - toxicity Vomiting - chemically induced
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