A genome-wide search for genes that relate to a low level of response to alcohol
The low level of response (LR) to alcohol is genetically influenced in both humans and animals, and a low LR is a characteristic of offspring of alcoholics that has been reported to predict alcoholism 10 and 15 years later. The genes that contribute to a low LR have not yet been identified. A 12-ite...
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| Veröffentlicht in: | Alcoholism, clinical and experimental research clinical and experimental research, 2001-03, Vol.25 (3), p.323-329 |
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| container_title | Alcoholism, clinical and experimental research |
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| creator | SCHUCKIT, M. A EDENBERG, H. J KALMIJN, J FLURY, L SMITH, T. L REICH, T BIERUT, L GOATE, A FOROUD, T |
| description | The low level of response (LR) to alcohol is genetically influenced in both humans and animals, and a low LR is a characteristic of offspring of alcoholics that has been reported to predict alcoholism 10 and 15 years later. The genes that contribute to a low LR have not yet been identified.
A 12-item questionnaire that measures LR, the Self Rating of the Effects of Alcohol (SRE) instrument, was filled out by 745 individuals from the Collaborative Study on the Genetics of Alcoholism (COGA) for whom genetic material was available. These subjects were genotyped by using 336 markers with an average heterozygosity of 0.74 and an average intermarker distance of 10.5 cM. Both quantitative and qualitative nonparametric, sib-pair analyses were carried out for the SRE measure related to early drinking experiences.
Correlations of SRE scores across related individuals were significant and between 0.16 and 0.22 for most values, compared with nonsignificant correlations of 0.03 or less among unrelated individuals. Linkage analyses performed by using the FIRST 5 variables (first five times alcohol is consumed) identified four chromosomal regions with lod scores > or = 2.0 whose maximum was also near a marker. One of these chromosomal regions previously was linked to alcohol dependence in the COGA sample.
These data document the familial nature of a low LR to alcohol as measured by the SRE and suggest several chromosomal regions that might contribute to the phenomenon. |
| doi_str_mv | 10.1097/00000374-200103000-00002 |
| format | Article |
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A 12-item questionnaire that measures LR, the Self Rating of the Effects of Alcohol (SRE) instrument, was filled out by 745 individuals from the Collaborative Study on the Genetics of Alcoholism (COGA) for whom genetic material was available. These subjects were genotyped by using 336 markers with an average heterozygosity of 0.74 and an average intermarker distance of 10.5 cM. Both quantitative and qualitative nonparametric, sib-pair analyses were carried out for the SRE measure related to early drinking experiences.
Correlations of SRE scores across related individuals were significant and between 0.16 and 0.22 for most values, compared with nonsignificant correlations of 0.03 or less among unrelated individuals. Linkage analyses performed by using the FIRST 5 variables (first five times alcohol is consumed) identified four chromosomal regions with lod scores > or = 2.0 whose maximum was also near a marker. One of these chromosomal regions previously was linked to alcohol dependence in the COGA sample.
These data document the familial nature of a low LR to alcohol as measured by the SRE and suggest several chromosomal regions that might contribute to the phenomenon.</description><identifier>ISSN: 0145-6008</identifier><identifier>EISSN: 1530-0277</identifier><identifier>DOI: 10.1097/00000374-200103000-00002</identifier><identifier>PMID: 11290841</identifier><identifier>CODEN: ACRSDM</identifier><language>eng</language><publisher>Baltimore, MD: Lippincott Williams & Wilkins</publisher><subject>Addictive behaviors ; Adult and adolescent clinical studies ; Alcoholism ; Alcoholism - epidemiology ; Alcoholism - genetics ; Alcoholism and acute alcohol poisoning ; Biological and medical sciences ; Drug Tolerance - genetics ; Female ; Genetic Linkage ; Genome, Human ; Genotype ; Humans ; Lod Score ; Male ; Medical sciences ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Factors ; Surveys and Questionnaires ; Toxicology</subject><ispartof>Alcoholism, clinical and experimental research, 2001-03, Vol.25 (3), p.323-329</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-fce53d734cc43ba8014daac2b80a1185ebfaf168ec65c1bc3cb34afa38c28db53</citedby><cites>FETCH-LOGICAL-c271t-fce53d734cc43ba8014daac2b80a1185ebfaf168ec65c1bc3cb34afa38c28db53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=920780$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11290841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHUCKIT, M. A</creatorcontrib><creatorcontrib>EDENBERG, H. J</creatorcontrib><creatorcontrib>KALMIJN, J</creatorcontrib><creatorcontrib>FLURY, L</creatorcontrib><creatorcontrib>SMITH, T. L</creatorcontrib><creatorcontrib>REICH, T</creatorcontrib><creatorcontrib>BIERUT, L</creatorcontrib><creatorcontrib>GOATE, A</creatorcontrib><creatorcontrib>FOROUD, T</creatorcontrib><title>A genome-wide search for genes that relate to a low level of response to alcohol</title><title>Alcoholism, clinical and experimental research</title><addtitle>Alcohol Clin Exp Res</addtitle><description>The low level of response (LR) to alcohol is genetically influenced in both humans and animals, and a low LR is a characteristic of offspring of alcoholics that has been reported to predict alcoholism 10 and 15 years later. The genes that contribute to a low LR have not yet been identified.
A 12-item questionnaire that measures LR, the Self Rating of the Effects of Alcohol (SRE) instrument, was filled out by 745 individuals from the Collaborative Study on the Genetics of Alcoholism (COGA) for whom genetic material was available. These subjects were genotyped by using 336 markers with an average heterozygosity of 0.74 and an average intermarker distance of 10.5 cM. Both quantitative and qualitative nonparametric, sib-pair analyses were carried out for the SRE measure related to early drinking experiences.
Correlations of SRE scores across related individuals were significant and between 0.16 and 0.22 for most values, compared with nonsignificant correlations of 0.03 or less among unrelated individuals. Linkage analyses performed by using the FIRST 5 variables (first five times alcohol is consumed) identified four chromosomal regions with lod scores > or = 2.0 whose maximum was also near a marker. One of these chromosomal regions previously was linked to alcohol dependence in the COGA sample.
These data document the familial nature of a low LR to alcohol as measured by the SRE and suggest several chromosomal regions that might contribute to the phenomenon.</description><subject>Addictive behaviors</subject><subject>Adult and adolescent clinical studies</subject><subject>Alcoholism</subject><subject>Alcoholism - epidemiology</subject><subject>Alcoholism - genetics</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Biological and medical sciences</subject><subject>Drug Tolerance - genetics</subject><subject>Female</subject><subject>Genetic Linkage</subject><subject>Genome, Human</subject><subject>Genotype</subject><subject>Humans</subject><subject>Lod Score</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Toxicology</subject><issn>0145-6008</issn><issn>1530-0277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUEtLAzEQDqLYWv0LEvC8msfuJj2W4gsKetDzMjs7sZW0Kclq8d-btVXnMnyvYfgY41JcSzE1N2IYbcpCCSGFzqAYGHXExrLSGShjjtlYyLIqaiHsiJ2l9J4dpa3rUzaSUk2FLeWYPc_4G23CmordqiOeCCIuuQtxoCnxfgk9j-ShJ94HDtyHHff0SZ4Hl4W0DZu0lzyGZfDn7MSBT3Rx2BP2enf7Mn8oFk_3j_PZokBlZF84pEp3RpeIpW7B5lc7AFStFSClrah14GRtCesKZYsaW12CA21R2a6t9ITZ_V2MIaVIrtnG1RriVyNFM5TU_JbU_JX0Q6kcvdxHtx_tmrr_4KGVbLg6GCAheBdhg6v055sqYazQ35PXbvU</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>SCHUCKIT, M. A</creator><creator>EDENBERG, H. J</creator><creator>KALMIJN, J</creator><creator>FLURY, L</creator><creator>SMITH, T. L</creator><creator>REICH, T</creator><creator>BIERUT, L</creator><creator>GOATE, A</creator><creator>FOROUD, T</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010301</creationdate><title>A genome-wide search for genes that relate to a low level of response to alcohol</title><author>SCHUCKIT, M. A ; EDENBERG, H. J ; KALMIJN, J ; FLURY, L ; SMITH, T. L ; REICH, T ; BIERUT, L ; GOATE, A ; FOROUD, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-fce53d734cc43ba8014daac2b80a1185ebfaf168ec65c1bc3cb34afa38c28db53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Addictive behaviors</topic><topic>Adult and adolescent clinical studies</topic><topic>Alcoholism</topic><topic>Alcoholism - epidemiology</topic><topic>Alcoholism - genetics</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Biological and medical sciences</topic><topic>Drug Tolerance - genetics</topic><topic>Female</topic><topic>Genetic Linkage</topic><topic>Genome, Human</topic><topic>Genotype</topic><topic>Humans</topic><topic>Lod Score</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHUCKIT, M. A</creatorcontrib><creatorcontrib>EDENBERG, H. J</creatorcontrib><creatorcontrib>KALMIJN, J</creatorcontrib><creatorcontrib>FLURY, L</creatorcontrib><creatorcontrib>SMITH, T. L</creatorcontrib><creatorcontrib>REICH, T</creatorcontrib><creatorcontrib>BIERUT, L</creatorcontrib><creatorcontrib>GOATE, A</creatorcontrib><creatorcontrib>FOROUD, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Alcoholism, clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHUCKIT, M. A</au><au>EDENBERG, H. J</au><au>KALMIJN, J</au><au>FLURY, L</au><au>SMITH, T. L</au><au>REICH, T</au><au>BIERUT, L</au><au>GOATE, A</au><au>FOROUD, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A genome-wide search for genes that relate to a low level of response to alcohol</atitle><jtitle>Alcoholism, clinical and experimental research</jtitle><addtitle>Alcohol Clin Exp Res</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>25</volume><issue>3</issue><spage>323</spage><epage>329</epage><pages>323-329</pages><issn>0145-6008</issn><eissn>1530-0277</eissn><coden>ACRSDM</coden><abstract>The low level of response (LR) to alcohol is genetically influenced in both humans and animals, and a low LR is a characteristic of offspring of alcoholics that has been reported to predict alcoholism 10 and 15 years later. The genes that contribute to a low LR have not yet been identified.
A 12-item questionnaire that measures LR, the Self Rating of the Effects of Alcohol (SRE) instrument, was filled out by 745 individuals from the Collaborative Study on the Genetics of Alcoholism (COGA) for whom genetic material was available. These subjects were genotyped by using 336 markers with an average heterozygosity of 0.74 and an average intermarker distance of 10.5 cM. Both quantitative and qualitative nonparametric, sib-pair analyses were carried out for the SRE measure related to early drinking experiences.
Correlations of SRE scores across related individuals were significant and between 0.16 and 0.22 for most values, compared with nonsignificant correlations of 0.03 or less among unrelated individuals. Linkage analyses performed by using the FIRST 5 variables (first five times alcohol is consumed) identified four chromosomal regions with lod scores > or = 2.0 whose maximum was also near a marker. One of these chromosomal regions previously was linked to alcohol dependence in the COGA sample.
These data document the familial nature of a low LR to alcohol as measured by the SRE and suggest several chromosomal regions that might contribute to the phenomenon.</abstract><cop>Baltimore, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11290841</pmid><doi>10.1097/00000374-200103000-00002</doi><tpages>7</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Journals@Ovid Complete |
| subjects | Addictive behaviors Adult and adolescent clinical studies Alcoholism Alcoholism - epidemiology Alcoholism - genetics Alcoholism and acute alcohol poisoning Biological and medical sciences Drug Tolerance - genetics Female Genetic Linkage Genome, Human Genotype Humans Lod Score Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors Surveys and Questionnaires Toxicology |
| title | A genome-wide search for genes that relate to a low level of response to alcohol |
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