The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane

The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis. Loss‐of‐function NIS variants cause congenital hypothyroidism due to impaired iodide accumulation in thyroid foll...

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Veröffentlicht in:	The FASEB journal 2021-08, Vol.35 (8), p.n/a
Hauptverfasser:	Martín, Mariano, Salleron, Lisa, Peyret, Victoria, Geysels, Romina Celeste, Darrouzet, Elisabeth, Lindenthal, Sabine, Bernal Barquero, Carlos Eduardo, Masini‐Repiso, Ana María, Pourcher, Thierry, Nicola, Juan Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	dyshormonogenic congenital hypothyroidism iodide transport defect PDZ domain‐containing protein SCRIB PDZ‐binding motif sodium/iodide symporter (NIS)
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