Activated Galectin‐9/Tim3 promotes Treg and suppresses Th1 effector function in chronic lymphocytic leukemia

Tim‐3 is a negative immunoregulator in anti‐tumor response, but its mechanism in chronic lymphocytic leukemia (CLL) is not yet clear. The aim of this study was to understand the role of Galectin‐9/Tim‐3 signaling pathway in the regulation of CD4+ T cell subsets in CLL patients. Flow cytometry result...

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Veröffentlicht in:	The FASEB journal 2021-07, Vol.35 (7), p.e21556-n/a, Article 21556
Hauptverfasser:	Pang, Nannan, Alimu, Xierenguli, Chen, Rong, Muhashi, Maliya, Ma, Jiajia, Chen, Gang, Zhao, Fang, Wang, Lei, Qu, Jianhua, Ding, Jianbing
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biochemistry & Molecular Biology Biology Case-Control Studies CD4+ T cell subset Cell Biology chronic lymphocytic leukemia (CLL) Female Galectins - genetics Galectins - metabolism Hepatitis A Virus Cellular Receptor 2 - genetics Hepatitis A Virus Cellular Receptor 2 - metabolism Humans Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Lymphocyte Activation - immunology Male Science & Technology Signal Transduction T-Lymphocytes, Regulatory - immunology Th1 Cells - immunology Tim‐3/Galectin‐9 signal pathway
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