Regulators of calcineurin 1 deficiency attenuates tubulointerstitial fibrosis through improving mitochondrial fitness

Renal fibrosis is the common pathological process of various chronic kidney diseases (CKD). Recent studies indicate that mitochondrial fragmentation is closely associated with renal fibrosis in CKD. However, the molecular mechanisms leading to mitochondrial fragmentation remain to be elucidated. The...

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Veröffentlicht in:	The FASEB journal 2020-11, Vol.34 (11), p.14539-n/a
Hauptverfasser:	Sang, Xue‐Yu, Xiao, Jing‐Jie, Liu, Qing, Zhu, Rui, Dai, Jia‐Jia, Zhang, Cheng, Yu, Hong, Yang, Si‐Jun, Zhang, Bai‐Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemistry & Molecular Biology Biology Calcium-Binding Proteins - physiology Cell Biology chronic kidney disease Epithelial-Mesenchymal Transition Fibrosis - etiology Fibrosis - pathology Fibrosis - prevention & control Humans Kidney Diseases - etiology Kidney Diseases - pathology Kidney Diseases - prevention & control Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - physiology mitochondrial fragmentation Muscle Proteins - physiology Reperfusion Injury - complications Science & Technology Signal Transduction Transforming Growth Factor beta1 - metabolism tubular apoptosis Ureteral Obstruction - complications
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