GR/Sp3/HDAC1/UGDH signaling participated in the maternal dexamethasone‐induced dysplasia of the rat fetal growth plate

Maternal dexamethasone decreases the body length of the newborn. However, whether dexamethasone inhibits the development of the growth plate of the fetal long bone is still unknown. Here, we found that lengths of fetal femur and growth plate were both shorter in the fetuses with maternal dexamethaso...

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Veröffentlicht in:	The FASEB journal 2020-09, Vol.34 (9), p.12834-12846
Hauptverfasser:	Wen, Yinxian, Shi, Huasong, Wu, Zhixin, Xiao, Hao, Wang, Hui, Chen, Liaobin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry & Molecular Biology Biology Cell Biology Cells, Cultured Dexamethasone - adverse effects Female Femur - drug effects Femur - embryology Femur - pathology Fetal Development - drug effects fetal growth plate Gene Expression Regulation, Developmental - drug effects Growth Plate - drug effects Growth Plate - embryology Growth Plate - pathology histone acetylation Histone Deacetylase 1 - metabolism Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Male maternal dexamethasone Maternal Exposure - adverse effects Maternal-Fetal Exchange Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Pregnancy proteoglycan Rats Rats, Wistar Receptors, Glucocorticoid - metabolism Science & Technology Signal Transduction Sp3 Transcription Factor - metabolism UDP‐glucose dehydrogenase Uridine Diphosphate Glucose Dehydrogenase - metabolism
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