Platelet activating factor receptor acts to limit colitis‐induced liver inflammation

Liver inflammation is a common extraintestinal manifestation in inflammatory bowel disease (IBD), yet, the mechanisms driving gut‐liver axis inflammation remain poorly understood. IBD leads to a breakdown in the integrity of the intestinal barrier causing an increase in portal and systemic gut‐deriv...

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Veröffentlicht in:	The FASEB journal 2020-06, Vol.34 (6), p.7718-7732
Hauptverfasser:	Liu, Gang, Baird, Alan W., Parsons, Marie J., Fan, Kening, Skerrett‐Byrne, David A., Nair, Prema M., Makanyengo, Samwel, Chen, Jinbiao, Neal, Rachel, Goggins, Bridie J., Tay, Hock, Mathe, Andrea, Soh, Wai S., Minahan, Kyra, Hansbro, Phil M., Nixon, Brett, McCaughan, Geoffrey W., Holtmann, Gerald, Colgan, Sean P., Keely, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caspase 1 - metabolism Cells, Cultured Colitis - chemically induced Colitis - metabolism Colitis - pathology Colon - metabolism Colon - pathology Dextran Sulfate - pharmacology extraintestinal manifestations in liver Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Humans Inflammasomes - metabolism Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology inflammatory bowel disease Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Interleukin-1beta - metabolism Kupffer Cells - metabolism Kupffer Cells - pathology Liver - drug effects Liver - metabolism Liver - pathology Male Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein - metabolism PAFR Platelet Membrane Glycoproteins - metabolism Receptors, G-Protein-Coupled - metabolism Toll-Like Receptor 4 - metabolism
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