Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling

It was recently demonstrated that antiestrogens prevented prostate cancer (PRCA) in men. The source of estradiol (E2) that contributes to carcinogenesis, as well as the selected estrogen receptor (ER) signaling pathway, is unknown. To evaluate estrogen's effects in carcinogenesis, we developed...

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Veröffentlicht in:	The FASEB journal 2008-05, Vol.22 (5), p.1512-1520
Hauptverfasser:	Ricke, William A, McPherson, Stephen J, Bianco, Joseph J, Cunha, Gerald R, Wang, Yuzhuo, Risbridger, Gail P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aromatase - deficiency Aromatase - physiology Estradiol - biosynthesis Estrogen Receptor alpha - deficiency Estrogen Receptor alpha - physiology Estrogen Receptor beta - metabolism hormone action Male Mice Mice, Inbred C57BL Mice, Knockout mouse models Prostate - drug effects Prostate - pathology prostate cancer Prostatic Neoplasms - chemically induced Prostatic Neoplasms - pathology Testosterone
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