Formation of tight junction: determinants of homophilic interaction between classic claudins

Claudins are the critical transmembrane proteins in tight junctions. Claudin-5, for instance, prevents paracellular permeation of small molecules. However, the molecular interaction mechanism is unknown. Hence, the claudin-claudin interaction and tight junction strand formation were investigated usi...

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Veröffentlicht in:	The FASEB journal 2008-01, Vol.22 (1), p.146-158
Hauptverfasser:	Piontek, Jörg, Winkler, Lars, Wolburg, Hartwig, Müller, Sebastian L, Zuleger, Nikolaj, Piehl, Christian, Wiesner, Burkhard, Krause, Gerd, Blasig, Ingolf E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Cell Line cell‐cell contacts Claudin-5 Fluorescence Resonance Energy Transfer freeze‐fracturing FRET Humans Immunohistochemistry Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Microscopy, Electron, Transmission Mutagenesis, Site-Directed protein‐protein interaction Subcellular Fractions - metabolism Tight Junctions transmembrane protein
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