The Toll‐like receptor 7/8‐ligand resiquimod (R‐848) primes human neutrophils for leukotriene B 4 , prostaglandin E 2 and platelet‐activating factor biosynthesis

Toll‐like receptors (TLR) recognize pathogen‐associated molecular patterns and play important roles in the innate immune system. While single‐stranded viral RNA is the natural ligand of TLR7/TLR8, the imidazoquinoline resiquimod (R‐848) is recognized as a potent synthetic agonist of TLR7/TLR8. We in...

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Veröffentlicht in:	The FASEB journal 2007-05, Vol.21 (7), p.1575-1585
Hauptverfasser:	Hattermann, Kim, Picard, Serge, Borgeat, Mathieu, Leclerc, Patrick, Pouliot, Marc, Borgeat, Pierre
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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