Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

ABSTRACTAlthough amyloid‐β peptide (Aβ) is the neurotoxic species implicated in the pathogenesis of Alzheimer's disease (AD), mechanisms through which intracellular Aβ impairs cellular properties, resulting in neuronal dysfunction, remain to be clarified. Here we demonstrate that intracellular...

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Veröffentlicht in:	The FASEB journal 2005-12, Vol.19 (14), p.2040-2041
Hauptverfasser:	Caspersen, Casper, Wang, Ning, Yao, Jun, Sosunov, Alexander, Chen, Xi, Lustbader, Joyce W., Xu, Hong Wei, Stern, David, McKhann, Guy, Du Yan, Shi
Format:	Artikel
Sprache:	eng
Schlagworte:	energy metabolism intracellular Aβ oxidative stress respiratory chain enzyme transgenic mouse model of Alzheimer's disease
Online-Zugang:	Volltext
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