Cysteinyl‐leukotriene receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl leukotrienes

ABSTRACT We studied the effect of intravascular activation of human neutrophils on the synthesis of cysteinyl leukotrienes (cysLT) and the formation of cerebral edema in guinea‐pig brains. Challenge with the chemotactic formylated tripeptide fMLP (0.1 µM) of neutrophil‐perfused brain in vitro result...

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Veröffentlicht in:	The FASEB journal 2004-05, Vol.18 (7), p.842-844
Hauptverfasser:	Gennaro, Antonio Di, Carnini, Chiara, Buccellati, Carola, Ballerio, Rossana, Zarini, Simona, Fumagalli, Francesca, Viappiani, Serena, Librizzi, Laura, Hernandez, Alicia, Murphy, Robert C., Constantin, Gabriela, Curtis, Marco, Folco, Giancarlo, Sala, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	endothelium leukotriene antagonists lipoxygenase inhibitors neutrophils paracrine communication
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